Patent Ductus Arteriosus in Preterm Neonates: A 2025 Synthesis of Evidence-Based Paradigms and Emerging Clinical Strategies

Aditya Hemendra Bhatt; Somashekhar Marutirao Nimbalkar; Dipen Vasudev Patel; Reshma Kushal Pujara

doi:10.1002/pdi3.70032

Pediatric Discovery ›› 2025, Vol. 3 ›› Issue (4) :e70032 DOI: 10.1002/pdi3.70032

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Patent Ductus Arteriosus in Preterm Neonates: A 2025 Synthesis of Evidence-Based Paradigms and Emerging Clinical Strategies

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Aditya Hemendra Bhatt, Somashekhar Marutirao Nimbalkar, Dipen Vasudev Patel, Reshma Kushal Pujara. Patent Ductus Arteriosus in Preterm Neonates: A 2025 Synthesis of Evidence-Based Paradigms and Emerging Clinical Strategies. Pediatric Discovery, 2025, 3(4): e70032 DOI:10.1002/pdi3.70032

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References

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[1]	N. Ambalavanan, S. W. Aucott, A. Salavitabar, et al., “Patent Ductus Arteriosus in Preterm Infants,” Pediatrics155, no. 5 (2025): e2025071425, https://doi.org/10.1542/peds.2025-071425.

[2]	W. E. Benitz, C. O. F. A. Newborn, K. L. Watterberg, et al., “Patent Ductus Arteriosus in Preterm Infants,” Pediatrics137, no. 1 (2016): e20153730, https://doi.org/10.1542/peds.2015-3730.

[3]	R. I. Clyman, M. Liebowitz, J. Kaempf, et al., “PDA-TOLERATE Trial: An Exploratory Randomized Controlled Trial of Treatment of Moderate-To-Large Patent Ductus Arteriosus at 1 Week of Age,” Journal of Pediatrics205 (2019): 41-48.e6, https://doi.org/10.1016/j.jpeds.2018.09.012.

[4]

T. Hundscheid, W. Onland, B. van Overmeire, et al., “Early Treatment Versus Expectative Management of Patent Ductus Arteriosus in Preterm Infants: A Multicentre, Randomised, Non-Inferiority Trial in Europe (BeNeDuctus Trial),” BMC Pediatrics18, no. 1 (2018): 262, https://doi.org/10.1186/s12887-018-1215-7.

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J. L. Bell, S. Gupta, E. Juszczak, P. Hardy, and L. Linsell, “Baby-OSCAR: Outcome After Selective Early Treatment for Closure of Patent Ductus ARteriosus in Preterm Babies-A Statistical Analysis Plan for Short-Term Outcomes,” Trials22, no. 1 (2021): 368, https://doi.org/10.1186/s13063-021-05324-3.

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2025 The Author(s). Pediatric Discovery published by John Wiley & Sons Australia, Ltd on behalf of Children's Hospital of Chongqing Medical University.