Highlighting the CORD-SaFe Trial From Melbourne—Progress Toward Cellular Therapy in Extremely Preterm Newborns

Aditya Bhatt; Somashekhar Nimbalkar; Dipen Patel; Reshma Pujara

doi:10.1002/pdi3.70021

Pediatric Discovery ›› 2025, Vol. 3 ›› Issue (4) :e70021 DOI: 10.1002/pdi3.70021

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Highlighting the CORD-SaFe Trial From Melbourne—Progress Toward Cellular Therapy in Extremely Preterm Newborns

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Aditya Bhatt, Somashekhar Nimbalkar, Dipen Patel, Reshma Pujara. Highlighting the CORD-SaFe Trial From Melbourne—Progress Toward Cellular Therapy in Extremely Preterm Newborns. Pediatric Discovery, 2025, 3(4): e70021 DOI:10.1002/pdi3.70021

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References

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[2]	J. Li, T. Yawno, A. Sutherland, et al., “The Early Administration of Umbilical Cord Blood Cells Can Prevent Preterm White Matter Brain Injury,” Experimental Neurology283 (September 2016): 179-187, https://doi.org/10.1016/j.expneurol.2016.06.017.

[3]	X. Peng, J. Song, B. Li, C. Zhu, and X. Wang, “Umbilical Cord Blood Stem Cell Therapy in Premature Brain Injury: Opportunities and Challenges,” Journal of Neuroscience Research98, no. 5 (May 2020): 815-825, https://doi.org/10.1002/jnr.24548.

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L. Zhou, C. A. McDonald, T. Yawno, et al., “Highlights of the Feasibility and Safety of Autologous Cord Blood-Derived Cell Administration in Extremely Preterm Infants: A Single-Centre, Open-Label, Single-Arm, Phase I Trial (CORD-SaFe Study),” EBioMedicine (January 2025): 111, https://doi.org/10.1016/j.ebiom.2024.105492.

[5]	Clinicaltrials.Gov. (2025) [cited 2025 Mar 26], https://clinicaltrials.gov/study/NCT06145035.

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2025 The Author(s). Pediatric Discovery published by John Wiley & Sons Australia, Ltd on behalf of Children's Hospital of Chongqing Medical University.