Linking first-pass reperfusion success to proteomic markers in large and medium vessel ischemic stroke: an exploratory study

Acknowledgments

This research was funded by the Spanish Ministry of Science and Innvation (grant Nos. PDC2021121455I00, PID2022141258OBI00), Xunta de Galicia (Axencia Galega de Innovación: IN607A202203) (Axencia Galega para a Xestión do Coñecemento en Saúde: SA304D-PRIS-T-2024/03), Instituto de Salud Carlos III (ISCIII) (ISCIII/PI21/01256/, PI24/00813, cofinanced by the European Union, DTS23/00103 and AC21_2/00014, under the frame of EuroNanoMed III). This work, integrated into the framework of PERTE for Cutting-edge Health, has been co-financed by the Spanish Ministry of Science, Innovation and Universities with funds from the European Union NextGenerationEU, from the Recovery, Transformation and Resilience Plan (PRTR-C17.I1), EBRAINS 2.0, European Union’s Research and Innovation Program Horizon Europe (No.101147319), and from the Autonomous Community of Galicia within the framework of the Biotechnology Plan Applied to Health. Furthermore, R.I.-R. received funding (CP22/00061) from the Miguel Servet Program of Instituto de Salud Carlos III, cofinanced by the EU. C Amodeo-Oblitas from the Rio Hortega Program of Instituto de Salud Carlos III (CM23/00173). The sponsors did not participate in the study design, data collection, analysis, or interpretation, nor in the writing of the report or the decision to submit the paper for publication.

Author contributions

Crhistian-Mario Oblitas (Conceptualization, Data curation, Formal analysis, Methodology, Writing—original draft), Sabela Fernández-Rodicio (Investigation, Writing—review & editing), Manuel Rodríguez-Yáñez (Investigation), Emilio Rodríguez-Castro (Investigation, Writing—review & editing), Arturo Gonzalez-Quintela (Writing—review & editing), Jacobo Porto-Álvarez (Investigation), Javier Martínez-Fernández (Investigation), Miguel Blanco (Investigation), Jose Luis Taboada (Investigation), Sara Reiriz (Investigation), Susana B. Bravo (Formal analysis, Software, Validation, Writing—review & editing), Carmen Pena (Formal analysis, Software), José Castillo (Conceptualization, Supervision, Writing—review & editing), Maria Luz Alonso-Alonso (Data curation, Methodology, Writing—review & editing), Pablo Hervella (Funding acquisition, Resources, Supervision, Visualization, Writing—review & editing), Antonio J. Mosqueira (Methodology, Writing—review & editing), and Ramón Iglesias-Rey (Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing—review & editing).

Supplementary materials

Supplementary material is available at PCMEDI Journal online.

Conflicts of interest

None declared.

Ethics statement

This research adheres to the principles of good clinical practice, as outlined in the Declaration of Helsinki by the World Medical As- sociation (1964) and its subsequent revisions in Fortaleza (2013). This study was approved by the local Ethics Committee (Xunta de Galicia/Servizo Galego de Saúde, registration code: 2023/282). In- formed consent was obtained from all patients (or authorized rep- resentatives) included in the study, with participant anonymity preserved.

Data availability statement

The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium via the PRIDE [ 9 ] partner repository with the dataset identifier PXD066161. The clinical database is not available for legal and ethical reasons.

References

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