Spatial genomics and brain spatial transcriptomic atlas for precision medicine

Wei Xiong , Alexander Hindeleh , Charles Wang

Precision Clinical Medicine ›› 2026, Vol. 9 ›› Issue (1) : pbag005

PDF (444KB)
Precision Clinical Medicine ›› 2026, Vol. 9 ›› Issue (1) :pbag005 DOI: 10.1093/pcmedi/pbag005
Opinion
research-article
Spatial genomics and brain spatial transcriptomic atlas for precision medicine
Author information +
History +
PDF (444KB)

Cite this article

Download citation ▾
Wei Xiong, Alexander Hindeleh, Charles Wang. Spatial genomics and brain spatial transcriptomic atlas for precision medicine. Precision Clinical Medicine, 2026, 9(1): pbag005 DOI:10.1093/pcmedi/pbag005

登录浏览全文

4963

注册一个新账户 忘记密码

Author contributions

Wei Xiong (Data curation, Investigation, Writing—original draft, Writing—review & editing), Alexander Hindeleh (Data curation, Investigation, Writing—original draft, Writing—review & editing), and Charles Wang (Conceptualization, Investigation, Project administration, Resources, Writing—review & editing).

Conflicts of interest

The authors declare no conflicts of interest. In addition, as an Editorial Board Member of Precision Clinical Medicine, the corresponding author Charles Wang was blinded from reviewing and making decisions on this manuscript.

References

[1]

Zhang M, Eichhorn SW, Zingg B et al. Spatially resolved cell atlas of the mouse primary motor cortex by MERFISH. Nature 2021; 598:137-43. https://doi.org/10.1038/s41586-021-03705-x.

[2]

Lein ES, Hawrylycz MJ, Ao N et al. Genome-wide atlas of gene expression in the adult mouse brain. Nature 2007; 445:168-76. https://doi.org/10.1038/nature05453.

[3]

Knopman DS, Amieva H, Petersen RC et al. Alzheimer disease. Nat Rev Dis Primers 2021; 7:33. https://doi.org/10.1038/s41572-021-00269-y.

[4]

Bloem BR, Okun MS, Klein C. Parkinson’s disease. The Lancet 2021; 397:2284-303. https://doi.org/10.1016/S0140-6736(21)00218-X.

[5]

Selkoe DJ, Hardy J. The amyloid hypothesis of Alzheimer’s disease at 25 years. EMBO Mol Med 2016; 8:595-608. https://doi.org/10.15252/emmm.201606210.

[6]

Chen S, Chang Y, Li L et al. Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer’s disease. Acta Neuropathologica Communications 2022; 10:188. https://doi.org/10.1186/s40478-022-01494-6.

[7]

Chen W-T, Lu A, Craessaerts K et al. Spatial transcriptomics and in situ sequencing to study Alzheimer’s disease. Cell 2020; 182:976-91. https://doi.org/10.1016/j.cell.2020.06.038.

[8]

Yabo YA, Heiland DH. Understanding glioblastoma at the single-cell level: recent advances and future challenges. PLoS Biol 2024; 22:e3002640. https://doi.org/10.1371/journal.pbio.3002640.

[9]

Lee S, Kim G, Lee J et al. Mapping cancer biology in space: applications and perspectives on spatial omics for oncology. Mol Cancer 2024; 23:26. https://doi.org/10.1186/s12943-024-01941-z.

[10]

Smith ACW, Ghoshal S, Centanni SW et al. A master regulator of opioid reward in the ventral prefrontal cortex. Science 2024; 384:eadn0886. https://doi.org/10.1126/science.adn0886.

PDF (444KB)

10

Accesses

0

Citation

Detail

Sections
Recommended

/