Artificial intelligence-driven peptide blocks gasdermin pyroptosis and alleviates inflammation

Mingsheng Liu , Hongqing Zhou , Min Wu

Precision Clinical Medicine ›› 2026, Vol. 9 ›› Issue (1) : pbag004

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Precision Clinical Medicine ›› 2026, Vol. 9 ›› Issue (1) :pbag004 DOI: 10.1093/pcmedi/pbag004
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Artificial intelligence-driven peptide blocks gasdermin pyroptosis and alleviates inflammation
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Mingsheng Liu, Hongqing Zhou, Min Wu. Artificial intelligence-driven peptide blocks gasdermin pyroptosis and alleviates inflammation. Precision Clinical Medicine, 2026, 9(1): pbag004 DOI:10.1093/pcmedi/pbag004

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Acknowledgements

This research was funded by the National Natural Science Foundation of China (grant Nos. 82160584 and 82470005) and the Key Research and Development Grant of MOST (grant No. 2023YFA095000), and was also supported by a startup fund from Wenzhou Institute of University of Chinese Academy of Sciences (grant No. WIUCASQD2022020).

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All authors drafted and approved the article.

Conflicts of interest

None declared. The corresponding author M.W. as an Editorial Board Member of Precision Clinical Medicine was blinded from reviewing and making decisions on this manuscript.

References

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Sun J, Yang J, Tao J et al. Delaying pyroptosis with AI-screened gasdermin D pore blocker mitigates inflammatory response. Nat Immunol 2025; 26:1660-72. https://doi.org/10.1038/s41590-025-02280-x

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Ding J, Wang K, Liu W et al. Pore-forming activity and structural autoinhibition of the gasdermin family. Nature 2016; 535:111-6. https://doi.org/10.1038/nature20106

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Wright SS, Kumari P, Fraile-Ágreda V et al. Transplantation of gasdermin pores by extracellular vesicles 878 propagates pyroptosis to bystander cells. Cell 2024; 188:280-91. https://doi.org/10.1016/j.cell.2024.11.018

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