A multi-omic study profiles women with PCOS to reveal unique gut microbiome compositions

Data availability

Demographic data and clinical measures are in supplemental Table 1; saliva SNPs in supplemental Table 2; differentially abundant taxa for PCOS vs. control samples in supplemental Table 3; detailed blood and questionnaire data are available upon request.

Ethics approval and consent to participate

This study was conducted by an ethics approval IRB number HP-00089723 at the University of Maryland School of Medicine, IRB Approval Date of 8/23/2021. ClinicalTrials.gov ID: NCT04981275 (Registration Date 7/28/21). All participants in this study provided written consent that their data from this study may be published albeit in a way that personal information will remain confidential.

Acknowledgments

This study was supported by the SBIR (small business innovation research program) grant of the National Institute of Health (grant No. 1R43HD103568-01 awarded to C.E.M.). We thank Thorne HealthTech, Inc. for providing at-home Gut Health kits.

Author contributions

Loukia Lili (Conceptualization, Data curation, Formal Analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing), Laura J. Kunces (Data curation, Project administration), Cem Meydan (Data curation, Formal Analysis, Investigation, Methodology, Writing - review & editing), Sarah Pesce (Resources, Supervision), Evan E. Afshin (Project administration, Resources, Writing - review & editing), Nate Rickard (Funding acquisition, Resources, Supervision, Writing - review & editing), Theresa M. Stujenske (Conceptualization, Funding acquisition, Writing - review & editing), Christopher R. D'Adamo (Project administration, Resources, Supervision, Writing - review & editing), Joel T. Dudley (Conceptualization, Investigation, Resources, Supervision), Bodi Zhang (Conceptualization, Funding acquisition, Investigation, Resources), and Christopher E. Mason (Conceptualization, Funding acquisition, Investigation, Resources, Writing - review & editing)

Supplementary data

Supplementary data is available at PCMEDI Journal online.

Conflict of interest

Authors who were full-time employees at Thorne HealthTech, Inc. at the time of the grant award: L.L., L.J.K., S.P., N.R., T.M.S., and B.Z. Authors who were part-time employees at Thorne HealthTech, Inc. at the time of the grant award: C.M., E.A.E., J.T.D., and C.E.M. Authors who were shareholders of Thorne HealthTech, Inc. at the time of the grant award: L.L., C.M., N.R., J.T.D., B.Z., and C.E.M. The following author claims no conflicts of interest: C.R.D. The funding received for this work was exclusively supported by the NIH SBIR award. Thorne HealthTech, Inc. provided the at-home Gut Health kits. In addition, as an Editorial Board Member of Precision Clinical Medicine, C.E.M. was blinded from reviewing and making decisions on this manuscript.

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