MET inhibitors as salvage therapy for MET-amplified gastric cancer with pulmonary lymphangitis

Xiufeng Zheng , Mo Cheng , Wenke Li , Ming Liu

Precision Clinical Medicine ›› 2025, Vol. 8 ›› Issue (1) : pbae035

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Precision Clinical Medicine ›› 2025, Vol. 8 ›› Issue (1) :pbae035 DOI: 10.1093/pcmedi/pbae035
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MET inhibitors as salvage therapy for MET-amplified gastric cancer with pulmonary lymphangitis

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Xiufeng Zheng, Mo Cheng, Wenke Li, Ming Liu. MET inhibitors as salvage therapy for MET-amplified gastric cancer with pulmonary lymphangitis. Precision Clinical Medicine, 2025, 8(1): pbae035 DOI:10.1093/pcmedi/pbae035

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Acknowledgements

This work was supported by the Sichuan Science and Technology Program (Grant No. 23ZDYF2874), and the 1.3.5 Project for Disciplines of Excellence, West China Hospital, Sichuan University (Grant No. ZYJC21043).

Author contributions

Xiufeng Zheng (Data curation, Formal analysis, Investigation, Writing—original draft), Mo Cheng (Data curation, Formal analysis, Writing—original draft), Wenke Li (Data curation), and Ming Liu (Funding acquisition, Supervision)

Conflict of interest

None declared.

Ethics

The study was approved by the Hospital Ethics Committee of West China Hospital, Sichuan University, and the need for written informed consent was waived.

References

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Mo MH, Liu P. Targeting MET in cancer therapy. Chronic Dis Transl Med 2017;3:148-53. https://doi.org/10.1016/j.cdtm.2017.06.002

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Zhang Z, Yu Y, Xie T et al. Pulmonary lymphangitis carcinomatosis: A peculiar presentation clustering in MET-amplified gastric cancer. Cancer Med 2023;12:19583-94. https://doi.org/10.1002/cam4.6575.

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Yu Y, Guo Q, Zhang Y et al. Savolitinib in patients in China with locally advanced or metastatic treatment-naive non-small-cell lung cancer harbouring MET exon 14 skipping mutations: results from a single-arm, multicohort, multicentre, open-label, phase 3b confirmatory study. The Lancet Respiratory Medicine 2024;12:958-66. https://doi.org/10.1016/S2213-2600(24)00211-X.

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Shah MA, Cho J-Y, Tan IB et al. A randomized phase II study of FOLFOX with or without the MET inhibitor onartuzumab in advanced adenocarcinoma of the stomach and gastroesophageal junction. Oncologist 2016;21:1085-90. https://doi.org/10.1634/th eoncologist.2016-0038.

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