Melatonin as a potential adjunct therapy for central nervous system lupus: evidence from the MRL/lpr mouse model

Jaivarshaan Rajkumar , Alexandra Spath , Hyndevi Dokuri , Alexander Jacob , Richard John Quigg , Jessy John Alexander

Precision Clinical Medicine ›› 2024, Vol. 7 ›› Issue (4) : pbae024

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Precision Clinical Medicine ›› 2024, Vol. 7 ›› Issue (4) :pbae024 DOI: 10.1093/pcmedi/pbae024
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Melatonin as a potential adjunct therapy for central nervous system lupus: evidence from the MRL/lpr mouse model

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Jaivarshaan Rajkumar, Alexandra Spath, Hyndevi Dokuri, Alexander Jacob, Richard John Quigg, Jessy John Alexander. Melatonin as a potential adjunct therapy for central nervous system lupus: evidence from the MRL/lpr mouse model. Precision Clinical Medicine, 2024, 7(4): pbae024 DOI:10.1093/pcmedi/pbae024

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Acknowledgements

This work was supported by the National Institutes of Health (Grant No. 1R01DK111222, to J.J.A.) and the Dr Arthur M. Morris endowment (to R.J.Q.).

Author contributions

Jaivarshaan Rajkumar (Data curation, Investigation, Methodology), Alexandra Spath (Data curation, Investigation, Methodology, Validation), Hyndevi Dokuri (Data curation, Methodology), Alexander Jacob (Methodology, Supervision, Validation, Writing—original draft), Richard J. Quigg (Conceptualization, Data curation, Resources, Writing—review & editing), and Jessy Alexander (Conceptualization, Methodology, Project administration, Supervision, Validation, Writing—original draft, Writing—review & editing)

Supplementary data

Supplementary data are available at PCMEDI online.

Conflict of interest

None declared. As an Editorial Board Member of Precision Clinical Medicine, the corresponding author J.J.A. was blinded from reviewing and making decisions on this manuscript.

Ethics statetment

All mice procedures and work described in this study were approved by the Institutional Animal Care and Use Committee. The protocol complies with the American Veterinary Medical Association (AVMA) Guidelines for the Euthanasia of Animals, and the ethical principles established by the National Institutes of Health Guide for the Care and Use of Laboratory Animals (NIH Publications No. 8523, revised 2011).

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