Mitigating the impact of skin necrosis in reconstruction after nipple-sparing mastectomy

Grant G. Black , Yunchan Chen , Marcos Lu Wang , Karina Condez , David M. Otterburn

Plastic and Aesthetic Research ›› 2023, Vol. 10 ›› Issue (1) : 31

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Plastic and Aesthetic Research ›› 2023, Vol. 10 ›› Issue (1) :31 DOI: 10.20517/2347-9264.2023.04
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Mitigating the impact of skin necrosis in reconstruction after nipple-sparing mastectomy

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Abstract

Skin flap necrosis is a common postoperative complication after breast reconstruction, with an incidence of up to 43.4% among patients undergoing nipple-sparing mastectomy. Necrosis can adversely impact aesthetics due to the need to excise nonviable tissue, and increase the risks of infection, implant loss, nipple-areola complex sacrifice and malposition. Patient-specific factors including age, body mass index, and breast size may affect the risk of necrosis. Mastectomy and reconstruction techniques (i.e., choosing between skin- and nipple-sparing mastectomy, and between autologous and alloplastic reconstruction) may also influence necrosis rates. Intraoperative measures such as indocyanine green angiography and autologous skin banking, and the postoperative use of nitroglycerin paste for high-risk patients and warming blankets for autologous reconstruction are methods to help prevent and minimize the morbidity of skin necrosis. Herein, we share our institution’s approaches to predicting and mitigating skin necrosis, and methods of optimizing outcomes for breast reconstruction patients.

Keywords

Mastectomy / breast reconstruction / necrosis / autologous flap / implant

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Grant G. Black, Yunchan Chen, Marcos Lu Wang, Karina Condez, David M. Otterburn. Mitigating the impact of skin necrosis in reconstruction after nipple-sparing mastectomy. Plastic and Aesthetic Research, 2023, 10(1): 31 DOI:10.20517/2347-9264.2023.04

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References

[1]

Breast Cancer Statistics. How common is breast cancer? Available from: https://www.cancer.org/cancer/breast-cancer/about/how-common-is-breast-cancer.html [Last accessed on 27 Jun 2023]

[2]

Carbine NE,Wallace J.Risk-reducing mastectomy for the prevention of primary breast cancer.Cochrane Database Syst Rev2018;4:CD002748 PMCID:PMC6494635

[3]

Dragun AE,Tucker TC.Increasing mastectomy rates among all age groups for early stage breast cancer: a 10-year study of surgical choice.Breast J2012;18:318-25

[4]

ASPS national clearinghouse of plastic surgery procedural statistics. Available from: https://www.plasticsurgery.org/documents/News/Statistics/2020/plastic-surgery-statistics-full-report-2020.pdf [Last accessed on 27 Jun 2023]

[5]

Colwell AS,Lin AM.Breast reconstruction following nipple-sparing mastectomy: predictors of complications, reconstruction outcomes, and 5-year trends.Plast Reconstr Surg2014;133:496-506

[6]

Oleck NC,Pyfer BJ.Defining mastectomy skin flap necrosis: a systematic review of the literature and a call for standardization.Plast Reconstr Surg2022;149:858e-66e

[7]

Gould DJ,Liu J.Impact of surgical techniques, biomaterials, and patient variables on rate of nipple necrosis after nipple-sparing mastectomy.Plast Reconstr Surg2013;132:330e-8e PMCID:PMC3935717

[8]

Patel KM,Gatti ME.Management of massive mastectomy skin flap necrosis following autologous breast reconstruction.Ann Plast Surg2012;69:139-44

[9]

Cho JW,You HJ,Lee BI.Nipple-areola complex necrosis after nipple-sparing mastectomy with immediate autologous breast reconstruction.Arch Plast Surg2015;42:601-7 PMCID:PMC4579172

[10]

Sue GR,Lee GK.Management of mastectomy skin necrosis in implant based breast reconstruction.Ann Plast Surg2017;78:S208-11

[11]

Nykiel M,Wong R.Management of mastectomy skin flap necrosis in autologous breast reconstruction.Ann Plast Surg2014;72:S31-4

[12]

Vargas CR,Anderson KE.Mastectomy skin necrosis after microsurgical breast reconstruction.J Surg Res2015;198:530-4

[13]

Akintayo RM,Olorunnipa OB.The price of aesthetics after nipple-sparring mastectomy: a cost-minimization analysis of skin banking with deep inferior epigastric perforator flap.Ann Plast Surg2020;84:300-6

[14]

Pataky RE.Reoperation costs in attempted breast-conserving surgery: a decision analysis.Curr Oncol2016;23:314-21 PMCID:PMC5081007

[15]

Algaithy ZK,Lohsiriwat V.Nipple sparing mastectomy: can we predict the factors predisposing to necrosis?.Eur J Surg Oncol2012;38:125-9

[16]

Ito H,Suga H.Risk factors for skin flap necrosis in breast cancer patients treated with mastectomy followed by immediate breast reconstruction.World J Surg2019;43:846-52

[17]

Matsen CB,Eaton A.Skin flap necrosis after mastectomy with reconstruction: a prospective study.Ann Surg Oncol2016;23:257-64 PMCID:PMC4697877

[18]

Lee TJ,Kim EK.Risk factors of mastectomy skin flap necrosis in immediate breast reconstruction using low abdominal flaps.J Plast Surg Hand Surg2016;50:302-6

[19]

Lu Wang M,Thomas G,Cohen LE.A comparative analysis of risk factors for breast skin necrosis following autologous versus device-based breast reconstruction.J Reconstr Microsurg2023;39:288-94

[20]

Andersen ES,Reuter Muñoz KD.The impact of preoperative breast volume on development of mastectomy skin flap necrosis in immediate breast reconstruction.Ann Plast Surg2022;88:S403-9

[21]

Lu Wang M,Qin N.Using clinical measurements to predict breast skin necrosis: a quantitative analysis.Ann Plast Surg2023;90:163-70

[22]

Wei CH,Price AN.Psychosocial and sexual well-being following nipple-sparing mastectomy and reconstruction.Breast J2016;22:10-7 PMCID:PMC4843778

[23]

Murthy V.Defining a place for nipple sparing mastectomy in modern breast care: an evidence based review.Breast J2013;19:571-81

[24]

Frey JD,Choi M.Optimizing outcomes in nipple-sparing mastectomy: mastectomy flap thickness is not one size fits all.Plast Reconstr Surg Glob Open2019;7:e2103 PMCID:PMC6382218

[25]

Robertson SA,Cutress RI.Determinants of optimal mastectomy skin flap thickness.Br J Surg2014;101:899-911

[26]

Garwood ER,Ewing C.Total skin-sparing mastectomy: complications and local recurrence rates in 2 cohorts of patients.Ann Surg2009;249:26-32

[27]

Carlson GW,Moyer HR,Losken A.Predictors of nipple ischemia after nipple sparing mastectomy.Breast J2014;20:69-73

[28]

Sue GR.Mastectomy skin necrosis after breast reconstruction: a comparative analysis between autologous reconstruction and implant-based reconstruction.Ann Plast Surg2018;80:S285-7

[29]

Huang H,Wang ML,Cohen LE.A comparison between immediate and babysitter deep inferior epigastric perforator flap breast reconstruction in postoperative outcomes.Ann Plast Surg2022;88:S179-83

[30]

Lauritzen E,Bonde C,Damsgaard TE.Indocyanine green angiography in breast reconstruction: a narrative review.Ann Breast Surg2022;6:6

[31]

Alander JT,Laakso A.A review of indocyanine green fluorescent imaging in surgery.Int J Biomed Imaging2012;2012:940585 PMCID:PMC3346977

[32]

Nguyen CL,Comerford AP.Cost-effectiveness of indocyanine green angiography in postmastectomy breast reconstruction.J Plast Reconstr Aesthet Surg2022;75:3014-21

[33]

Moyer HR.Predicting mastectomy skin flap necrosis with indocyanine green angiography: the gray area defined.Plast Reconstr Surg2012;129:1043-8

[34]

Komorowska-Timek E.Intraoperative perfusion mapping with laser-assisted indocyanine green imaging can predict and prevent complications in immediate breast reconstruction.Plast Reconstr Surg2010;125:1065-73

[35]

Kovach SJ.The "banked" TRAM: a method to insure mastectomy skin-flap survival.Ann Plast Surg2006;57:366-9

[36]

Reichl H,Wechselberger G.Skin banking: treatment option for native skin necrosis following skin-sparing mastectomy and previous breast irradiation.Microsurgery2011;31:314-7

[37]

Yun MH,Lee BI.The effect of low-dose nitroglycerin ointment on skin flap necrosis in breast reconstruction after skin-sparing or nipple-sparing mastectomy.Arch Plast Surg2017;44:509-15 PMCID:PMC5801789

[38]

Robertson SA,Agrawal A.Mastectomy skin flap necrosis: challenges and solutions.Breast Cancer2017;9:141-52 PMCID:PMC5357072

[39]

Turin SY,Vaca EE.Nitroglycerin ointment for reducing the rate of mastectomy flap necrosis in immediate implant-based breast reconstruction.Plast Reconstr Surg2018;142:264e-70e

[40]

Gdalevitch P,Bahng S.Effects of nitroglycerin ointment on mastectomy flap necrosis in immediate breast reconstruction: a randomized controlled trial.Plast Reconstr Surg2015;135:1530-9

[41]

Gardenier JC,Hespe GE.Topical tacrolimus for the treatment of secondary lymphedema.Nat Commun2017;8:14345. PMCID:PMC5309859

[42]

Van YVR,Lu C.The effect of topical tacrolimus on pedicled flap survival.Ann Plast Surg2020;85:S118-21.

[43]

Wald G,Towne W.The effect of topical tacrolimus on pedicled flap survival: a histological analysis.Ann Plast Surg2021;87:S57-9.

[44]

Zukowski ML,Ash K.Precautions in warming light therapy as an adjuvant to postoperative flap care.Burns1998;24:374-7.

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