Complex upper extremity injuries: targeted muscle reinnervation, free functional muscle transfer, and vascularized composite allotransplantation

Jonathan Bekisz , Jacques H. Hacquebord

Plastic and Aesthetic Research ›› 2022, Vol. 9 ›› Issue (1) : 61

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Plastic and Aesthetic Research ›› 2022, Vol. 9 ›› Issue (1) :61 DOI: 10.20517/2347-9264.2022.69
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Complex upper extremity injuries: targeted muscle reinnervation, free functional muscle transfer, and vascularized composite allotransplantation

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Abstract

Restoration of upper extremity function poses a unique surgical challenge. With considerations ranging from ensuring appropriate skeletal support and musculotendinous and ligamentous anatomy, restoring adequate vascularity and innervation, and providing sufficient soft tissue coverage, upper extremity injuries present a diverse range of reconstructive problems. Recent history has been marked by an expansion of novel techniques for addressing these complex issues. Sophisticated modalities, such as targeted muscle reinnervation, free functional muscle transfer, and vascularized composite allotransplantation, have become some of the most powerful tools in the armamentarium of the reconstructive surgeon. This review article aims to define the distinguishing features of each of these modalities and reviews some of their unique advantages and limitations.

Keywords

Targeted muscle reinnervation / free functional muscle transfer / vascularized composite allotransplantation

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Jonathan Bekisz, Jacques H. Hacquebord. Complex upper extremity injuries: targeted muscle reinnervation, free functional muscle transfer, and vascularized composite allotransplantation. Plastic and Aesthetic Research, 2022, 9(1): 61 DOI:10.20517/2347-9264.2022.69

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References

[1]

Bernstein ML.Early management of the mangled upper extremity.Injury2007;38 Suppl 5:S3-7

[2]

Alphonsus CK.Principles in the management of a mangled hand.Indian J Plast Surg2011;44:219-26 PMCID:PMC3193634

[3]

Bumbasirevic M,Lesic A.Current management of the mangled upper extremity.Int Orthop2012;36:2189-95 PMCID:PMC3479293

[4]

Savetsky IL,Salibian AA.A novel mangled upper extremity injury assessment score.Plast Reconstr Surg Glob Open2019;7:e2449 PMCID:PMC6908405

[5]

Bates TJ,Pierrie SN.Technological advances in prosthesis design and rehabilitation following upper extremity limb loss.Curr Rev Musculoskelet Med2020;13:485-93 PMCID:PMC7340716

[6]

Malt RA.Replantation of severed arms.JAMA1964;189:716-22

[7]

Komatsu S.Successful replantation of a completely cut-off thumb.Plast Reconstr Surg1968;42:374-7

[8]

Buncke H.Recent advances in microsurgery.Calif Med1970;113:66-7. PMCID:PMC1501790

[9]

Buncke HJ Jr.Important advances in microsurgery.Calif Med1972;116:54. PMCID:PMC1518139

[10]

Urbanchek MG,Frost CM.Development of a regenerative peripheral nerve interface for control of a neuroprosthetic limb.Biomed Res Int2016;2016:5726730 PMCID:PMC4886043

[11]

Frost CM,Flattery SM.Regenerative peripheral nerve interfaces for real-time, proportional control of a Neuroprosthetic hand.J Neuroeng Rehabil2018;15:108 PMCID:PMC6245539

[12]

Vu PP,Irwin ZT.A regenerative peripheral nerve interface allows real-time control of an artificial hand in upper limb amputees.Sci Transl Med2020;12:eaay2857 PMCID:PMC8082695

[13]

Cheesborough JE,Dumanian GA.Targeted muscle reinnervation in the initial management of traumatic upper extremity amputation injury.Hand2014;9:253-7 PMCID:PMC4022965

[14]

Cheesborough JE,Kuiken TA.Targeted muscle reinnervation and advanced prosthetic arms.Semin Plast Surg2015;29:62-72 PMCID:PMC4317279

[15]

Vu PP,Nason SR,Kemp SWP.The future of upper extremity rehabilitation robotics: research and practice.Muscle Nerve2020;61:708-18 PMCID:PMC7868083

[16]

Mioton LM,Shah N.Targeted muscle reinnervation improves residual limb pain, phantom limb pain, and limb function: a prospective study of 33 major limb amputees.Clin Orthop Relat Res2020;478:2161-7 PMCID:PMC7431223

[17]

Agrawal N,Pickrell BB,Valerio IL.The octopus procedure combined with targeted muscle reinnervation for elective transhumeral amputation.Plast Reconstr Surg Glob Open2021;9:e3931 PMCID:PMC8594661

[18]

Aman M,Sporer ME.Bionic reconstruction: restoration of extremity function with osseointegrated and mind-controlled prostheses.Wien Klin Wochenschr2019;131:599-607 PMCID:PMC6908564

[19]

Seal A.Free functional muscle transfer for the upper extremity.Clin Plast Surg2011;38:561-75

[20]

Fischer JP,Kozin SH.Free function muscle transfers for upper extremity reconstruction: a review of indications, techniques, and outcomes.J Hand Surg Am2013;38:2485-90

[21]

Schaverien MV.Free muscle flaps for reconstruction of upper limb defects.Hand Clin2014;30:165-83, v

[22]

Stevanovic M.Functional free muscle transfer for upper extremity reconstruction.Plast Reconstr Surg2014;134:257e-74e

[23]

Krauss EM,Moore AM.Free functional muscle transfers to restore upper extremity function.Hand Clin2016;32:243-56

[24]

Dubernard JM,Herzberg G.Human hand allograft: report on first 6 months.Lancet1999;353:1315-20

[25]

Elsberg CA.Experiments on motor nerve regeneration and the direct neurotization of paralyzed muscles by their own and by foreign nerves.Science1917;45:318-20

[26]

Dumanian GA,Mioton LM.Targeted muscle reinnervation treats neuroma and phantom pain in major limb amputees: a randomized clinical trial.Ann Surg2019;270:238-46

[27]

Kuiken TA,Hargrove L.Targeted muscle reinnervation for the upper and lower extremity.Tech Orthop2017;32:109-16 PMCID:PMC5448419

[28]

Gart MS,Dumanian GA.Targeted muscle reinnervation in the upper extremity amputee: a technical roadmap.J Hand Surg Am2015;40:1877-88

[29]

Efanov JI,Izadpanah A,Danino MA.A review of utilities and costs of treating upper extremity amputations with vascularized composite allotransplantation versus myoelectric prostheses in Canada.JPRAS Open2022;32:150-60 PMCID:PMC8989691

[30]

Resnik L,Lieberman-Klinger S.Advanced upper limb prosthetic devices: implications for upper limb prosthetic rehabilitation.Arch Phys Med Rehabil2012;93:710-7

[31]

Bouwsema H,Bongers RM.Changes in performance over time while learning to use a myoelectric prosthesis.J Neuroeng Rehabil2014;11:16 PMCID:PMC3944783

[32]

Yamamoto M,Sterbenz J.Cross-sectional international multicenter study on quality of life and reasons for abandonment of upper limb prostheses.Plast Reconstr Surg Glob Open2019;7:e2205 PMCID:PMC6571339

[33]

Terzis JK.Free muscle transfer in posttraumatic plexopathies: part 1: the shoulder.Ann Plast Surg2010;65:312-7

[34]

Reed AJ,Wormald JC,Shirley R.Free functional muscle transfer for upper limb paralysis - a systematic review.J Plast Reconstr Aesthet Surg2022;75:1001-17

[35]

Kay S,Wiper J,Jones F.Microvascular free functioning gracilis transfer with nerve transfer to establish elbow flexion.J Plast Reconstr Aesthet Surg2010;63:1142-9

[36]

Sood A,Russo G.Functional latissimus dorsi transfer for upper-extremity reconstruction: a case report and review of the literature.Eplasty2017;17:e5 PMCID:PMC5317028

[37]

Terzis JK.Free muscle transfer in posttraumatic plexopathies part II: the elbow.Hand2010;5:160-70 PMCID:PMC5317028

[38]

Terzis JK.Free muscle transfer in posttraumatic plexopathies: part III. The hand.Plast Reconstr Surg2009;124:1225-36

[39]

Dibbs R,Pederson WC.Free tissue transfer for upper extremity reconstruction.Semin Plast Surg2019;33:17-23 PMCID:PMC6408247

[40]

Mackinnon SE.Nerve transfers. New options for reconstruction following nerve injury.Hand Clin1999;15:643-66, ix

[41]

Chen J,Wang H,Yang J.Functional outcome of contralateral C7 nerve transfer combined with free functional gracilis transplantation to repair total brachial plexus avulsion: a report of thirty-nine cases.Int Orthop2022;46:1053-62 PMCID:PMC9001549

[42]

Addas BM.Nerve transfers for severe nerve injury.Neurosurg Clin N Am2009;20:27-38, vi

[43]

Sun G,Wang X,Gu Y.Nerve transfer helps repair brachial plexus injury by increasing cerebral cortical plasticity.Neural Regen Res2014;9:2111-4 PMCID:PMC4316477

[44]

Schreiber JJ,Khair MM,Lee SK.Optimal axon counts for brachial plexus nerve transfers to restore elbow flexion.Plast Reconstr Surg2015;135:135e-41e

[45]

Nicoson MC,Tung TH.Donor nerve sources in free functional gracilis muscle transfer for elbow flexion in adult brachial plexus injury.Microsurgery2017;37:377-82

[46]

Cho AB,Pisani MJ.Comparison between donor nerves to motorize the free functional gracilis muscle transfer for elbow flexion: Retrospective study of 38 consecutive cases in traumatic adult brachial plexus injuries.Microsurgery2019;39:400-4

[47]

Millard DR. Principlization of plastic surgery. 1st ed. Boston: Little, Brown; 1986.

[48]

Shores JT,Lee WPA.Hand and upper extremity transplantation: an update of outcomes in the worldwide experience.Plast Reconstr Surg2015;135:351e-60e

[49]

Shores JT,Lee WPA.Outcomes after hand and upper extremity transplantation.J Mater Sci Mater Med2017;28:72

[50]

Leonard DA,Kurtz JM.Tolerance induction strategies in vascularized composite allotransplantation: mixed chimerism and novel developments.Clin Dev Immunol2012;2012:863264 PMCID:PMC3540904

[51]

Cetrulo CL Jr,Sachs DH.Tolerance induction via mixed chimerism in vascularized composite allotransplantation: is it time for clinical application?.Curr Opin Organ Transplant2015;20:602-7

[52]

Bramstedt KA.A lifesaving view of vascularized composite allotransplantation: patient experience of social death before and after face, hand, and larynx transplant.J Patient Exp2018;5:92-100 PMCID:PMC6022947

[53]

Kinsley SE,Lape EC.Perceived success in upper-extremity vascularized composite allotransplantation: a qualitative study.J Hand Surg Am2021;46:711.e1-711.e35

[54]

Breidenbach WC,Becker GW.A statistical comparative assessment of face and hand transplantation outcomes to determine whether either meets the standard of care threshold.Plast Reconstr Surg2016;137:214e-222e

[55]

Singh M,Carty M.Functional outcomes after bilateral hand transplantation: a 3.5-year comprehensive follow-up.Plast Reconstr Surg2016;137:185-9

[56]

Efanov JI,Bou-Merhi J,Danino MA.Applying health utility outcome measures and quality-adjusted life-years to compare hand allotransplantation and myoelectric prostheses for upper extremity amputations.Plast Reconstr Surg2022;149:465e-74e

[57]

Williams N.Dash.Occup Med2014;64:67-8

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