Diagnosis, management and prevention of thrombotic complications in microsurgical breast reconstruction: a review of the literature

Amy Chen , Shannon R. Garvey , Asha Nanda , Bernard T. Lee , Ryan P. Cauley

Plastic and Aesthetic Research ›› 2023, Vol. 10 ›› Issue (1) : 24

PDF
Plastic and Aesthetic Research ›› 2023, Vol. 10 ›› Issue (1) :24 DOI: 10.20517/2347-9264.2022.136
Review

Diagnosis, management and prevention of thrombotic complications in microsurgical breast reconstruction: a review of the literature

Author information +
History +
PDF

Abstract

Autologous free tissue transfer is a safe and effective option for breast reconstruction. It is an increasingly utilized technique with well-demonstrated improved patient satisfaction and quality of life. Microvascular thrombosis is a rare but significant complication of microsurgical breast reconstruction, often resulting in flap failure. Proper diagnosis and timely management of this complication are essential to free flap salvage. While microvascular thrombosis poses a threat to flap survival, several methods may be employed to mitigate its more devastating effects. Here, we present a comprehensive review of arterial and venous thrombotic complications in both the intraoperative and postoperative settings. We discuss preoperative risk assessment, methods for flap monitoring, and operative and medical management of thrombotic complications. We present an updated algorithm for the intraoperative management of microvascular thrombosis adapted to reflect the most recent literature and our novel algorithm for the postoperative management of microvascular thrombosis.

Keywords

Breast microsurgery / free flap monitoring / free flap thrombosis / free flap salvage

Cite this article

Download citation ▾
Amy Chen, Shannon R. Garvey, Asha Nanda, Bernard T. Lee, Ryan P. Cauley. Diagnosis, management and prevention of thrombotic complications in microsurgical breast reconstruction: a review of the literature. Plastic and Aesthetic Research, 2023, 10(1): 24 DOI:10.20517/2347-9264.2022.136

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Durry A,Mathelin C,Bodin F.[Patients' satisfaction after immediate breast reconstruction: comparison between five surgical techniques].Ann Chir Plast Esthet2019;64:217-23

[2]

He WY,Yesantharao P.Complications and patient-reported outcomes after tram and diep flaps: a systematic review and meta-analysis.Plast Reconstr Surg Glob Open2020;8:e3120.

[3]

Khajuria A,Greenfield M.A meta-analysis of clinical, patient-reported outcomes and cost of DIEP versus implant-based breast reconstruction.Plast Reconstr Surg Glob Open2019;7:e2486

[4]

Fischer JP,Nelson JA.Comprehensive outcome and cost analysis of free tissue transfer for breast reconstruction: an experience with 1303 flaps.Plast Reconstr Surg2013;131:195-203

[5]

Fischer JP,Cleveland E.Breast reconstruction modality outcome study: a comparison of expander/implants and free flaps in select patients.Plast Reconstr Surg2013;131:928-34

[6]

Gill PS,Guerra AB.A 10-year retrospective review of 758 DIEP flaps for breast reconstruction.Plast Reconstr Surg2004;113:1153-60

[7]

Masoomi H,Paydar KZ.Predictive risk factors of free flap thrombosis in breast reconstruction surgery.Microsurgery2014;34:589-94

[8]

Anderson FA Jr.Risk factors for venous thromboembolism.Circulation2003;107:I9-16

[9]

Khansa I,Tomich DC,Lee BT.Factor V leiden associated with flap loss in microsurgical breast reconstruction.Microsurgery2011;31:409-12

[10]

Herrera FA,Kryger G.Microsurgery in the hypercoagulable patient: review of the literature.J Reconstr Microsurg2012;28:305-12

[11]

Davison SP,Al-Attar A.Microvascular free flap failure caused by unrecognized hypercoagulability.Plast Reconstr Surg2009;124:490-5

[12]

Wang TY,Cuker A.Free tissue transfer in the hypercoagulable patient: a review of 58 flaps.Plast Reconstr Surg2012;129:443-53

[13]

Pannucci CJ,Cuker A.Microsurgery and the hypercoagulable state: a hematologist's perspective.Plast Reconstr Surg2015;136:545e-52e

[14]

Friedman T,Michaels V J.Hereditary coagulopathies: practical diagnosis and management for the plastic surgeon.Plast Reconstr Surg2010;125:1544-52

[15]

Nahabedian MY,Galdino G.Breast reconstruction with the free TRAM or DIEP flap: patient selection, choice of flap, and outcome.Plast Reconstr Surg2002;110:466-75

[16]

Spear SL,Cuoco F.Effect of obesity on flap and donor-site complications in pedicled TRAM flap breast reconstruction.Plast Reconstr Surg2007;119:788-95

[17]

Hanwright PJ,Hirsch EM.The differential effect of BMI on prosthetic versus autogenous breast reconstruction: a multivariate analysis of 12,986 patients.Breast2013;22:938-45

[18]

Chang DW,Robb GL.Effect of obesity on flap and donor-site complications in free transverse rectus abdominis myocutaneous flap breast reconstruction.Plast Reconstr Surg2000;105:1640-8

[19]

Fischer JP,Sieber B.Free tissue transfer in the obese patient: an outcome and cost analysis in 1258 consecutive abdominally based reconstructions.Plast Reconstr Surg2013;131:681e-92e

[20]

Chang DW,Robb GL.Effect of obesity on flap and donor-site complications in free transverse rectus abdominis myocutaneous flap breast reconstruction.Plast Reconstr Surg2000;105:1640-8

[21]

Heidekrueger PI,Moellhoff N.Impact of body mass index on free DIEP flap breast reconstruction: a multicenter cohort study.J Plast Reconstr Aesthet Surg2021;74:1718-24

[22]

Nolan J,Kurihara K.The acute effects of cigarette smoke exposure on experimental skin flaps.Plast Reconstr Surg1985;75:544-51

[23]

Gu YD,Zhang LY,Jiang JF.Clinical and experimental studies of cigarette smoking in microvascular tissue transfers.Microsurgery1993;14:391-7

[24]

van Adrichem LN,Hovius SE.The effect of cigarette smoking on the survival of free vascularized and pedicled epigastric flaps in the rat.Plast Reconstr Surg1996;97:86-96

[25]

Khouri RK,Kunselman AR.A prospective study of microvascular free-flap surgery and outcome.Plast Reconstr Surg1998;102:711-21

[26]

Arnez ZM,Bardsley AF,Webster MH.Experience with 50 free TRAM flap breast reconstructions.Plast Reconstr Surg1991;87:470-8.

[27]

Padubidri AN,Browne E.Complications of postmastectomy breast reconstructions in smokers, ex-smokers, and nonsmokers.Plast Reconstr Surg2001;107:342-9

[28]

Baker DG.The response of the microvascular system to radiation: a review.Cancer Invest1989;7:287-94

[29]

Baker SR,Panje WR.Radiation effects on microvascular anastomosis.Arch Otolaryngol1978;104:103-7

[30]

Arinci A,Aydin I.Effects of early pre- and postoperative irradiation on the healing of microvascular anastomoses.J Reconstr Microsurg2000;16:573-6

[31]

Park JG, Yun HK, Ahn ST. The effect of radiation on the patency of end-to-side microvascular anastomosis. J Korean Soc Plast Reconstr Surg 2001:565-570. Available from: https://pesquisa.bvsalud.org/portal/resource/pt/wpr-70630 [Last accessed on 30 May 2023]

[32]

Barrera-Ochoa S,López-Fernández A.Effect of previous irradiation on vascular thrombosis of microsurgical anastomosis: a preclinical study in rats.Plast Reconstr Surg Glob Open2016;4:e1073 PMCID:PMC5142475

[33]

Fracol ME,Nelson JA.Bilateral free flap breast reconstruction after unilateral radiation: comparing intraoperative vascular complications and postoperative outcomes in radiated versus nonradiated breasts.Ann Plast Surg2016;76:311-4

[34]

Fosnot J,Smartt JM Jr.Does previous chest wall irradiation increase vascular complications in free autologous breast reconstruction?.Plast Reconstr Surg2011;127:496-504

[35]

Rogers NE.Radiation effects on breast reconstruction with the deep inferior epigastric perforator flap.Plast Reconstr Surg2002;109:1919-24

[36]

Tran NV,Gupta A,Robb GL.Comparison of immediate and delayed free TRAM flap breast reconstruction in patients receiving postmastectomy radiation therapy.Plast Reconstr Surg2001;108:78-82

[37]

Khavanin N,Colakoglu S.Breast Reconstruction trends in the setting of postmastectomy radiation therapy: analysis of practices among plastic surgeons in the United States.Plast Reconstr Surg Glob Open2023;11:e4800 PMCID:PMC9937102

[38]

Lee M,McClure E.Surgeon motivations behind the timing of breast reconstruction in patients requiring postmastectomy radiation therapy.J Plast Reconstr Aesthet Surg2015;68:1536-42 PMCID:PMC4659387

[39]

Baumann DP,Selber JC.Optimal timing of delayed free lower abdominal flap breast reconstruction after postmastectomy radiation therapy.Plast Reconstr Surg2011;127:1100-6

[40]

Meier CR.Tamoxifen and risk of idiopathic venous thromboembolism.Br J Clin Pharmacol1998;45:608-12 PMCID:PMC1873655

[41]

Lin HF,Chang CM,Lai SW.Correlation of the tamoxifen use with the increased risk of deep vein thrombosis and pulmonary embolism in elderly women with breast cancer: a case-control study.Medicine2018;97:e12842 PMCID:PMC6320050

[42]

Decensi A,Rotmensz N.Italian Tamoxifen Study GroupEffect of tamoxifen on venous thromboembolic events in a breast cancer prevention trial.Circulation2005;111:650-6

[43]

Debbie Jiang. Thrombotic Risk from Chemotherapy and Other Cancer Therapies. In: Soff G, editor. Thrombosis and hemostasis in cancer. Cham: Springer International Publishing; 2019. pp. 87-101.

[44]

Kelley BP,Yi M.Tamoxifen increases the risk of microvascular flap complications in patients undergoing microvascular breast reconstruction.Plast Reconstr Surg2012;129:305-14 PMCID:PMC3921070

[45]

Jokuszies A,Betzler C.Is tamoxifen associated with an increased risk for thromboembolic complications in patients undergoing microvascular breast reconstruction?.Ger Med Sci2013;11:Doc05 PMCID:PMC3575563

[46]

Parikh RP,Yu L,Myckatyn TM.Complications and thromboembolic events associated with tamoxifen therapy in patients with breast cancer undergoing microvascular breast reconstruction: a systematic review and meta-analysis.Breast Cancer Res Treat2017;163:1-10 PMCID:PMC5554619

[47]

Tran BNN,Cohen JB.Does Hormone Therapy Use Increase Perioperative Complications in Abdominally Based Microsurgical Breast Reconstruction?.Plast Reconstr Surg2018;141:805e-13e

[48]

Mirzabeigi MN,Fischer JP.Tamoxifen (selective estrogen-receptor modulators) and aromatase inhibitors as potential perioperative thrombotic risk factors in free flap breast reconstruction.Plast Reconstr Surg2015;135:670e-9e

[49]

Billon R,Belkacemi Y.Impact of adjuvant anti-estrogen therapies (tamoxifen and aromatase inhibitors) on perioperative outcomes of breast reconstruction.J Plast Reconstr Aesthet Surg2017;70:1495-504

[50]

Salibian AA,Gu J.The effects of perioperative tamoxifen therapy on microvascular flap complications in transverse rectus abdominis myocutaneous/deep inferior epigastric perforator flap breast reconstruction.Ann Plast Surg2016;77:630-4

[51]

Ritter EF,Rudner AM,Klitzman B.Improved microsurgical anastomotic patency with low molecular weight heparin.J Reconstr Microsurg1998;14:331-6

[52]

Zhang B,Wieslander JB.A comparison of the early antithrombotic effects between low molecular weight heparin and heparin in small arteries following a severe trauma: an experimental study.Ann Plast Surg1993;31:255-61

[53]

Lighthall JG,Wieslander TA.Effect of postoperative aspirin on outcomes in microvascular free tissue transfer surgery.Otolaryngol Head Neck Surg2013;148:40-6

[54]

Zhou W,Yu Y.Are antithrombotic agents necessary for head and neck microvascular surgery?.Int J Oral Maxillofac Surg2019;48:869-74

[55]

Chen CM,Disa JJ.Is the use of intraoperative heparin safe?.Plast Reconstr Surg2008;121:49e-53e

[56]

Kroll SS,Reece GP.Anticoagulants and hematomas in free flap surgery.Plast Reconstr Surg1995;96:643-7

[57]

Ashjian P,Pusic A.The effect of postoperative anticoagulation on microvascular thrombosis.Ann Plast Surg2007;59:36-9

[58]

Conrad MH.Pharmacologic optimization of microsurgery in the new millennium.Plast Reconstr Surg2001;108:2088-96

[59]

Stephan B,Nemeh A.The use of antithrombotic agents in microvascular surgery.Clin Hemorheol Microcirc2009;43:51-6

[60]

Brinkman JN,Klimek M.Perioperative fluid management and use of vasoactive and antithrombotic agents in free flap surgery: a literature review and clinical recommendations.J Reconstr Microsurg2013;29:357-66

[61]

Liu J,Yang S.Does postoperative anticoagulation therapy lead to a higher success rate for microvascular free-tissue transfer in the head and neck? a systematic review and meta-analysis.J Reconstr Microsurg2018;34:87-94

[62]

Microsurgery essentials: intra-operative technique. Available from: https://plasticsurgery.stanford.edu/education/microsurgery/intraoperative.html [Last accessed on 23 May 2023]

[63]

Krag C.The value of the patency test in microvascular anastomosis: correlation between observed patency and size of intraluminal thrombus: an experimental study in rats.Br J Plast Surg1981;34:64-6

[64]

Phillips BT,Conkling N.Intraoperative perfusion techniques can accurately predict mastectomy skin flap necrosis in breast reconstruction: results of a prospective trial.Plast Reconstr Surg2012;129:778e-88e

[65]

Komorowska-Timek E.Intraoperative perfusion mapping with laser-assisted indocyanine green imaging can predict and prevent complications in immediate breast reconstruction.Plast Reconstr Surg2010;125:1065-73

[66]

Chatterjee A,Van Vliet MM.A comparison of free autologous breast reconstruction with and without the use of laser-assisted indocyanine green angiography: a cost-effectiveness analysis.Plast Reconstr Surg2013;131:693e-701e

[67]

Lee BT,Hutteman M.Intraoperative near-infrared fluorescence imaging in perforator flap reconstruction: current research and early clinical experience.J Reconstr Microsurg2010;26:59-65 PMCID:PMC3100538

[68]

Ludolph I,Arkudas A.Enhancing safety in reconstructive microsurgery using intraoperative indocyanine green angiography.Front Surg2019;6:39 PMCID:PMC6614526

[69]

Yoshimatsu H,Scaglioni MF.Application of intraoperative indocyanine green angiography for detecting flap congestion in the use of free deep inferior epigastric perforator flaps for breast reconstruction.Microsurgery2021;41:522-6

[70]

Sharaf JM,Henderson PW.Comments on "application of intraoperative indocyanine green angiography for detecting flap congestion in the use of free deep inferior epigastric perforator flaps for breast reconstruction".Microsurgery2022;42:99-100

[71]

Vijan SS.Microvascular breast reconstruction pedicle thrombosis: how long can we wait?.Microsurgery2007;27:544-7

[72]

Mirzabeigi MN,Kovach ST.Free flap take-back following postoperative microvascular compromise: predicting salvage versus failure..Plast Reconstr Surg2012;130:579-89

[73]

Creech B. Evaluation of circulation in skin flaps. In W.C. Grabb, M.B. Myers (Eds.), Skin Flaps. Boston: Little, Brown. 1975.

[74]

Jones BM.Monitors for the cutaneous microcirculation.Plast Reconstr Surg1984;73:843-50

[75]

Jacobson A.Review of flap monitoring technology in 2020.Facial Plast Surg2020;36:722-6

[76]

Busic V.Temperature monitoring in free flap surgery.Br J Plast Surg2004;57:588

[77]

Mericli AF,Garvey PB.A prospective clinical trial comparing visible light spectroscopy to handheld doppler for postoperative free tissue transfer monitoring.Plast Reconstr Surg2017;140:604-13

[78]

Smit JM,Acosta R.Advancements in free flap monitoring in the last decade: a critical review.Plast Reconstr Surg2010;125:177-85

[79]

Ong AA,Pipkorn P.Implantable doppler removal after free flap monitoring among head and neck microvascular surgeons.Laryngoscope2022;132:554-9

[80]

Karinja SJ.Advances in flap monitoring and impact of enhanced recovery protocols.J Surg Oncol2018;118:758-67

[81]

Lin SJ,Chen C.Tissue oximetry monitoring in microsurgical breast reconstruction decreases flap loss and improves rate of flap salvage.Plast Reconstr Surg2011;127:1080-5

[82]

Pelletier A,Agarwal S,Song D.Cost analysis of near-infrared spectroscopy tissue oximetry for monitoring autologous free tissue breast reconstruction.J Reconstr Microsurg2011;27:487-94

[83]

Ricci JA,Ho OA.Evaluating the use of tissue oximetry to decrease intensive unit monitoring for free flap breast reconstruction.Ann Plast Surg2017;79:42-6

[84]

Lindelauf AAMA,Rutjens VGH.Economic analysis of noninvasive tissue oximetry for postoperative monitoring of deep inferior epigastric perforator flap breast reconstruction: a review.Surg Innov2020;27:534-42 PMCID:PMC7816549

[85]

Ricci JA,Lin SJ.A novel free flap monitoring system using tissue oximetry with text message alerts.J Reconstr Microsurg2016;32:415-20

[86]

Zoccali G,Farhadi J.Is long-term post-operative monitoring of microsurgical flaps still necessary?.J Plast Reconstr Aesthet Surg2017;70:996-1000

[87]

Bonde C,Eriksen K.Introducing the fast track surgery principles can reduce length of stay after autologous breast reconstruction using free flaps: a case control study.J Plast Surg Hand Surg2015;49:367-71

[88]

Astanehe A,Nielsen M.An enhanced recovery after surgery pathway for microvascular breast reconstruction is safe and effective.Plast Reconstr Surg Glob Open2018;6:e1634 PMCID:PMC5811294

[89]

Carruthers KH,Yoshida S.Inpatient flap monitoring after deep inferior epigastric artery perforator flap breast reconstruction: how long is long enough?.J Reconstr Microsurg2019;35:682-7

[90]

Khansa I,Taghizadeh M.A systematic approach to emergent breast free flap takeback: Clinical outcomes, algorithm, and review of the literature.Microsurgery2013;33:505-13

[91]

Williams JG,Lalonde DH.Why do free flap vessels thrombose? lessons learned from implantable doppler monitoring.Can J Plast Surg2004;12:23-6 PMCID:PMC3792763

[92]

Chen C,Bar-Meir E.Effects of vasopressor administration on the outcomes of microsurgical breast reconstruction.Ann Plast Surg2010;65:28-31

[93]

Banic A,Erni D,Sigurdsson GH.Effects of sodium nitroprusside and phenylephrine on blood flow in free musculocutaneous flaps during general anesthesia.Anesthesiology1999;90:147-55

[94]

Massey MF.The effects of systemic phenylephrine and epinephrine on pedicle artery and microvascular perfusion in a pig model of myoadipocutaneous rotational flaps.Plast Reconstr Surg2007;120:1289-99

[95]

Yu JT,Malata CM.The use of topical vasodilators in microvascular surgery.J Plast Reconstr Aesthet Surg2011;64:226-8

[96]

Vargas CR,Lee BT.A systematic review of topical vasodilators for the treatment of intraoperative vasospasm in reconstructive microsurgery.Plast Reconstr Surg2015;136:411-22

[97]

Ricci JA,Shah J.Comparing the outcomes of different agents to treat vasospasm at microsurgical anastomosis during the papaverine shortage.Plast Reconstr Surg2016;138:401e-8e

[98]

Ricci JA,Fukudome EY.Topical nitroglycerin for the treatment of intraoperative microsurgical vasospasm.Microsurgery2018;38:524-9

[99]

Couteau C,Guillier D,Revol M.Improving free-flap survival using intra-operative heparin: ritualistic practice or evidence-base medicine? a systematic review.Ann Chir Plast Esthet2018;63:e1-5

[100]

Troeltzsch M,Probst FA.Current concepts in salvage procedures for failing microvascular flaps: is there a superior technique?.Int J Oral Maxillofac Surg2016;45:1378-87

[101]

Hong KY,Chang H,Jin US.Direct thrombectomy as a salvage technique in free flap breast reconstruction.Microsurgery2017;37:402-5

[102]

Kamali A,Edsander Nord Å.Increased salvage rates with early reexploration: a retrospective analysis of 547 free flap cases.J Plast Reconstr Aesthet Surg2021;74:2479-85

[103]

Coriddi M,Mehrara B.Management of postoperative microvascular compromise and ischemia reperfusion injury in breast reconstruction using autologous tissue transfer: retrospective review of 2103 flaps.Microsurgery2022;42:109-16 PMCID:PMC8810672

[104]

Tran NV,Convery PA.Microvascular complications of DIEP flaps.Plast Reconstr Surg2007;119:1397-405

[105]

Khouri RK.Avoiding free flap failure.Clin Plast Surg1992;19:773-81

[106]

Nimalan N,Stocks G.Anaesthesia for free flap breast reconstruction.BJA Education2016;16:162-6

[107]

Blondeel PN,Verstraete K.Venous congestion and blood flow in free transverse rectus abdominis myocutaneous and deep inferior epigastric perforator flaps.Plast Reconstr Surg2000;106:1295-9

[108]

Heller L.Lower extremity microsurgical reconstruction.Plast Reconstr Surg2001;108:1029-41

[109]

Galanis C,Koh J.Microvascular lifeboats: a stepwise approach to intraoperative venous congestion in DIEP flap breast reconstruction.Plast Reconstr Surg2014;134:20-7

[110]

Wheatley MJ.The role of vascular pedicle thrombectomy in the management of compromised free tissue transfers.Ann Plast Surg1996;36:360-4

[111]

Kim DY,Kim EK,Eom JS.Intraoperative venous congestion in free transverse rectus abdominis musculocutaneous and deep inferior epigastric artery perforator flaps during breast reconstruction: A systematic review.Plast Surg2015;23:255-9 PMCID:PMC4664142

[112]

Baumann DP,Chevray PM.Perforator number predicts fat necrosis in a prospective analysis of breast reconstruction with free TRAM, DIEP, and SIEA flaps.Plast Reconstr Surg2010;125:1335-41

[113]

Ochoa O,Chrysopoulo M,Arishita G.Salvage of intraoperative deep inferior epigastric perforator flap venous congestion with augmentation of venous outflow: flap morbidity and review of the literature.Plast Reconstr Surg Glob Open2013;1:e52 PMCID:PMC4174054

[114]

Enajat M,Whitaker IS,Acosta R.A single center comparison of one versus two venous anastomoses in 564 consecutive DIEP flaps: investigating the effect on venous congestion and flap survival.Microsurgery2010;30:185-91

[115]

Seong IH.Comparison of the second and third intercostal spaces regarding the use of internal mammary vessels as recipient vessels in DIEP flap breast reconstruction: An anatomical and clinical study.Arch Plast Surg2020;47:333-9 PMCID:PMC7398814

[116]

Kerr-Valentic MA,Agarwal JP.The retrograde limb of the internal mammary vein: an additional outflow option in DIEP flap breast reconstruction.Plast Reconstr Surg2009;124:717-21

[117]

Gravvanis A,Papalois A.The retrograde limb of the internal mammary vein in the swine model: a sufficient outflow option in free tissue transfer.Plast Reconstr Surg2010;125:1298-9

[118]

Li S,Li Y.Breast reconstruction with the free bipedicled inferior TRAM flap by anastomosis to the proximal and distal ends of the internal mammary vessels.J Reconstr Microsurg2002;18:161-8

[119]

Mohebali J,Agarwal JP.Further validation for use of the retrograde limb of the internal mammary vein in deep inferior epigastric perforator flap breast reconstruction using laser-assisted indocyanine green angiography.J Reconstr Microsurg2010;26:131-5

[120]

Mackey SP.Exploring the myth of the valveless internal mammary vein--a cadaveric study.J Plast Reconstr Aesthet Surg2011;64:1174-9

[121]

Rohde C.Novel technique for venous augmentation in a free deep inferior epigastric perforator flap.Ann Plast Surg2005;55:528-30

[122]

Jindal R,Valerio IL,De La Cruz C.Alleviation of venous congestion in muscle-sparing free TRAM flaps with a temporary angiocatheter.Plast Reconstr Surg2010;126:29e-31e

[123]

Davies A,Wilson SM.Microvascular lifeboats: a stepwise approach to intraoperative venous congestion in DIEP flap breast reconstruction.Plast Reconstr Surg2015;135:638e-9e

[124]

Bank J,Shore AM.Mechanical leeching with venocutaneous fistula and monitoring with near-infrared spectroscopy.Plast Reconstr Surg Glob Open2013;1:e56 PMCID:PMC4174058

[125]

Nelson JA,Eftakhari K.Late venous thrombosis in free flap breast reconstruction: strategies for salvage after this real entity.Plast Reconstr Surg2012;129:8e-15e

[126]

Chaput B,Grolleau JL,Bekara F.Reply: the stitches could be the main risk for failure in perforator-pedicled flaps.Plast Reconstr Surg2016;138:383e-5e

[127]

Boissiere F,Riot S.Flap venous congestion and salvage techniques: a systematic literature review.Plast Reconstr Surg Glob Open2021;9:e3327 PMCID:PMC7858245

[128]

Katira K,Venditto C,Doren EL.Successful salvage of delayed venous congestion after diep flap breast reconstruction.Eplasty2019;19:e22 PMCID:PMC6916620

[129]

Gdalevitch P,Bahng S.Effects of nitroglycerin ointment on mastectomy flap necrosis in immediate breast reconstruction: a randomized controlled trial.Plast Reconstr Surg2015;135:1530-9

[130]

Wang P,Qin Z,Ma J.Efficacy and safety of topical nitroglycerin in the prevention of mastectomy flap necrosis: a systematic review and meta-analysis.Sci Rep2020;10:6753 PMCID:PMC7174291

[131]

Chu CK,Kaplan J,Hanasono MM.The chicken or the egg? relationship between venous congestion and hematoma in free flaps.J Plast Reconstr Aesthet Surg2020;73:1442-7

[132]

Yoon AP.Critical time for neovascularization/angiogenesis to allow free flap survival after delayed postoperative anastomotic compromise without surgical intervention: a review of the literature.Microsurgery2016;36:604-12

[133]

Hanasono MM.Prevention and treatment of thrombosis in microvascular surgery.J Reconstr Microsurg2008;24:305-14

[134]

Khouri RK,Kenna DM.Thrombosis of microvascular anastomoses in traumatized vessels: fibrin versus platelets.Plast Reconstr Surg1990;86:110-7

[135]

Pérez M,Ferrer C,Barret JP.Management of flap venous congestion: the role of heparin local subcutaneous injection.J Plast Reconstr Aesthet Surg2014;67:48-55

[136]

Talbot SG.First aid for failing flaps.J Reconstr Microsurg2010;26:513-5

[137]

Akan IM,Gideroğlu K.Salvage of flaps with venous congestion.Ann Plast Surg2001;46:456

[138]

Knobloch K,Busch K,Vogt PM.[Hirudo medicinalis-leech applications in plastic and reconstructive microsurgery--a literature review].Handchir Mikrochir Plast Chir2007;39:103-7

[139]

Hackenberger PN.A comprehensive review of medicinal leeches in plastic and reconstructive surgery.Plast Reconstr Surg Glob Open2019;7:e2555 PMCID:PMC7288891

[140]

Conforti ML,Heisey DM.Evaluation of performance characteristics of the medicinal leech (Hirudo medicinalis) for the treatment of venous congestion.Plast Reconstr Surg2002;109:228-35

[141]

Pannucci CJ,Chung CU.Medicinal leeches for surgically uncorrectable venous congestion after free flap breast reconstruction.Microsurgery2014;34:522-6

[142]

Gürsoy K,Uysal A.Dealing with the venous congestion of free flaps: venous catheterization.J Craniofac Surg2008;19:1645-7

[143]

Eskitascioglu T,Ozyazgan I.Salvage of venous congested flaps by simple methods.Plast Reconstr Surg2006;117:344-6

[144]

Caplin DA,Couper SG.Salvage of TRAM flaps with compromised venous outflow.Plast Reconstr Surg2000;106:400-1

[145]

Mozafari N,Hosseini SN.Comparisons of medicinal leech therapy with venous catheterization in the treatment of venous congestion of the sural flap.Microsurgery2011;31:36-40

[146]

Goldstein JA,Brown B.The use of negative pressure wound therapy for random local flaps at the ankle region.J Foot Ankle Surg2010;49:513-6

[147]

Qiu SS,Hanna SA.Negative pressure wound therapy for the management of flaps with venous congestion.Microsurgery2016;36:467-73

[148]

Uygur F,Ulkür E.The role of the vacuum-assisted closure therapy in the salvage of venous congestion of the free flap: case report.Int Wound J2008;5:50-3 PMCID:PMC7951192

[149]

van den Heuvel MG,Bast A.Review: ischaemia-reperfusion injury in flap surgery.J Plast Reconstr Aesthet Surg2009;62:721-6

[150]

Marre D.Increments in ischaemia time induces microvascular complications in the DIEP flap for breast reconstruction.J Plast Reconstr Aesthet Surg2013;66:80-6

[151]

Im MJ,Bulkley GB.Effects of superoxide dismutase and allopurinol on the survival of acute island skin flaps.Ann Surg1985;201:357-9 PMCID:PMC1250680

[152]

Suzuki S,Isshiki N,Miyachi Y.Involvement of reactive oxygen species in post-ischaemic flap necrosis and its prevention by antioxidants.Br J Plast Surg1991;44:130-4

[153]

Aydogan H,Parlakpinar H.Beneficial effects of caffeic acid phenethyl ester (CAPE) on the ischaemia-reperfusion injury in rat skin flaps.J Plast Reconstr Aesthet Surg2007;60:563-8

[154]

Gurlek A,Parlakpinar H,Bay-Karabulut A.The protective effect of melatonin on ischemia-reperfusion injury in the groin (inferior epigastric) flap model in rats.J Pineal Res2006;40:312-7

[155]

Chappell D,Hofmann-Kiefer K.Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx.Anesthesiology2007;107:776-84

[156]

Akdemir O,Zhang F.Effects of taurine on reperfusion injury.J Plast Reconstr Aesthet Surg2011;64:921-8

[157]

Del Rio M,Malagón-López P.Effect of intravenous lidocaine on ischemia-reperfusion injury in DIEP microsurgical breast reconstruction. a prospective double-blind randomized controlled clinical trial.J Plast Reconstr Aesthet Surg2021;74:809-18

[158]

Koolen PG,Ibrahim AM.Effects of statins on ischemia-reperfusion complications in breast free flaps.J Surg Res2014;190:378-84

[159]

van den Heuvel MG,Ambergen AW.The effect of statins and other cardiovascular medication on ischemia-reperfusion damage in a human DIEP flap model: theoretical and epidemiological considerations.J Transplant2012;2012:504081 PMCID:PMC3357555

[160]

Baumeister S,Zenn MR,Levin LS.Strategy for reoperative free flaps after failure of a first flap.Plast Reconstr Surg2008;122:962-71

[161]

Hamdi M,Thiessen F.Is a second free flap still an option in a failed free flap breast reconstruction?.Plast Reconstr Surg2010;126:375-84

[162]

Um GT,Louie O.Implantable cook-swartz doppler probe versus synovis flow coupler for the post-operative monitoring of free flap breast reconstruction.J Plast Reconstr Aesthet Surg2014;67:960-6

[163]

Rozen WM,Whitaker IS.The efficacy of postoperative monitoring: a single surgeon comparison of clinical monitoring and the implantable Doppler probe in 547 consecutive free flaps.Microsurgery2010;30:105-10

[164]

Rozen WM,Whitaker IS.Postoperative monitoring of free flaps in autologous breast reconstruction: a multicenter comparison of 398 flaps using clinical monitoring, microdialysis, and the implantable Doppler probe.J Reconstr Microsurg2010;26:409-16

[165]

Smit JM,Liss AG,Kildal M.Post operative monitoring of microvascular breast reconstructions using the implantable Cook-Swartz doppler system: a study of 145 probes & technical discussion.J Plast Reconstr Aesthet Surg2009;62:1286-92

[166]

Schmulder A,Zaretski A.Eight-year experience of the cook-swartz doppler in free-flap operations: microsurgical and reexploration results with regard to a wide spectrum of surgeries.Microsurgery2011;31:1-6

[167]

Chang EI,Zhang H.Deciphering the sensitivity and specificity of the implantable doppler probe in free flap monitoring.Plast Reconstr Surg2016;137:971-6

[168]

Frost MW,Rozen WM.Direct comparison of postoperative monitoring of free flaps with microdialysis, implantable cook-swartz doppler probe, and clinical monitoring in 20 consecutive patients.Microsurgery2015;35:262-71

[169]

Kempton SJ,Chen JT.Free flap monitoring using an implantable anastomotic venous flow coupler: analysis of 119 consecutive abdominal-based free flaps for breast reconstruction.Microsurgery2015;35:337-44

[170]

Jacob DD,Cakmakoglu C.Color Duplex ultrasound for localization of vascular compromise in microsurgical breast reconstruction.Plast Reconstr Surg2020;145:666e-7e

[171]

Arya R,Figus A.Post-operative assessment of perfusion of deep inferior epigastric perforator (DIEP) free flaps via pulsatility index (PI) using a portable colour doppler sonogram device.J Plast Reconstr Aesthet Surg2013;66:931-6

[172]

Rothenberger J,Schaller HE.Evaluation of a non-invasive monitoring method for free flap breast reconstruction using laser doppler flowmetrie and tissue spectrophotometry.Microsurgery2013;33:350-7

[173]

Kumbasar DE,Dawood O,Blackburn A.Monitoring Breast reconstruction flaps using near-infrared spectroscopy tissue oximetry.Plast Surg Nurs2021;41:108-11

[174]

Whitaker IS,Rozen WM.Near infrared spectroscopy for monitoring flap viability following breast reconstruction.J Reconstr Microsurg2012;28:149-54

[175]

Repez A,Arnez ZM.Continuous postoperative monitoring of cutaneous free flaps using near infrared spectroscopy.J Plast Reconstr Aesthet Surg2008;61:71-7

[176]

Trignano E,Fiorot L.Flap monitoring with continuous oxygen partial tension measurement in breast reconstructive surgery: a preliminary report.Microsurgery2018;38:402-6

[177]

Keller A.A new diagnostic algorithm for early prediction of vascular compromise in 208 microsurgical flaps using tissue oxygen saturation measurements.Ann Plast Surg2009;62:538-43

[178]

Koolen PGL,Ho OA.Does increased experience with tissue oximetry monitoring in microsurgical breast reconstruction lead to decreased flap loss? the learning effect.Plast Reconstr Surg2016;137:1093-101

[179]

Fox PM,Carey J.White light spectroscopy for free flap monitoring.Microsurgery2013;33:198-202

[180]

Schrögendorfer KF,Keck M.Viability of five different pre- and intraoperative imaging methods for autologous breast reconstruction.Eur Surg2016;48:326-33 PMCID:PMC5660891

[181]

Holm C,Sturtz G.Sensitivity and specificity of ICG angiography in free flap reexploration.J Reconstr Microsurg2010;26:311-6

PDF

76

Accesses

0

Citation

Detail

Sections
Recommended

/