Recent advancements in supermicrosurgical treatment of lymphedema

Samer Jabbour , Edward I. Chang

Plastic and Aesthetic Research ›› 2021, Vol. 8 ›› Issue (1) : 43

PDF
Plastic and Aesthetic Research ›› 2021, Vol. 8 ›› Issue (1) :43 DOI: 10.20517/2347-9264.2021.59
Review

Recent advancements in supermicrosurgical treatment of lymphedema

Author information +
History +
PDF

Abstract

Surgical treatment for lymphedema has undergone tremendous advancements over the years, with the earliest techniques focusing on ablative procedures such as liposuction and direct excision. With modern advancements in technology, equipment, imaging, and microscope optics, physiologic procedures have emerged as the standard of care for lymphedema at high-volume institutions and centers of excellence. The lymphovenous bypass and the vascularized lymph node transfer operations have both proven to be effective means for treatment and improving the quality of life of patients suffering from lymphedema. However, with the established foundation of knowledge and experience, innovative approaches to optimize outcomes in patients undergoing supermicrosurgical treatment are constantly evolving. The present review presents a historical review of the lymphovenous bypass and vascularized lymph node transfer procedures and introduces some novel expansions of both techniques in the field of lymphedema surgery.

Keywords

Lymph-venous bypass / vascularized lymph node transfer / prophylactic repair of vessels in the axilla with immediate LVB

Cite this article

Download citation ▾
Samer Jabbour, Edward I. Chang. Recent advancements in supermicrosurgical treatment of lymphedema. Plastic and Aesthetic Research, 2021, 8(1): 43 DOI:10.20517/2347-9264.2021.59

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

Naoum GE,Brunelle CL.Quantifying the impact of axillary surgery and nodal irradiation on breast cancer-related lymphedema and local tumor control: long-term results from a prospective screening trial.J Clin Oncol2020;38:3430-8 PMCID:PMC7527159

[2]

Armer JM,McCall L.Factors associated with lymphedema in women with node-positive breast cancer treated with neoadjuvant chemotherapy and axillary dissection.JAMA Surg2019;154:800-9 PMCID:PMC6647005

[3]

Byun HK,Im SH.Risk of lymphedema following contemporary treatment for breast cancer: an analysis of 7617 consecutive patients from a multidisciplinary perspective.Ann Surg2021;274:170-8

[4]

McLaughlin SA,Morris KT.Prevalence of lymphedema in women with breast cancer 5 years after sentinel lymph node biopsy or axillary dissection: objective measurements.J Clin Oncol2008;26:5213-9 PMCID:PMC2652091

[5]

Silva AK.Vascularized lymph node transfer and lymphovenous bypass: novel treatment strategies for symptomatic lymphedema.J Surg Oncol2016;113:932-9

[6]

Raju A.Vascularized lymph node transfer for treatment of lymphedema: a comprehensive literature review.Ann Surg2015;261:1013-23

[7]

Chang EI,Chang DW.Lymphovenous anastomosis bypass surgery.Semin Plast Surg2018;32:22-7 PMCID:PMC5891648

[8]

Garza RM.Lymphovenous bypass for the treatment of lymphedema.J Surg Oncol2018;118:743-9

[9]

Chang DW,Skoracki R.A prospective analysis of 100 consecutive lymphovenous bypass cases for treatment of extremity lymphedema.Plast Reconstr Surg2013;132:1305-14

[10]

Scaglioni MF,Arvanitakis M.Systematic review of lymphovenous anastomosis (LVA) for the treatment of lymphedema.Microsurgery2017;37:947-53

[11]

Yang JC,Wu SC,Chiang MH.Supermicrosurgical lymphaticovenous anastomosis as an alternative treatment option for patients with lymphorrhea.Plast Reconstr Surg2019;144:1214-24

[12]

Yang JC,Lin WC,Chiang PL.Supermicrosurgical lymphaticovenous anastomosis as alternative treatment option for moderate-to-severe lower limb lymphedema.J Am Coll Surg2020;230:216-27

[13]

Garcés M, Pons G, Mirapeix R, Masià J. Intratissue lymphovenous communications in the mechanism of action of vascularized lymph node transfer.J Surg Oncol2017;115:27-31

[14]

Liu HL,Lee CC,Chung HP.Orthotopic transfer of vascularized groin lymph node flap in the treatment of breast cancer-related lymphedema: Clinical results, lymphoscintigraphy findings, and proposed mechanism.J Plast Reconstr Aesthet Surg2018;71:1033-40

[15]

Joseph WJ,Ghanta S.Sterile inflammation after lymph node transfer improves lymphatic function and regeneration.Plast Reconstr Surg2014;134:60-8 PMCID:PMC4101920

[16]

Chang EI,Hanson SE,Hanasono MM.Comprehensive overview of available donor sites for vascularized lymph node transfer.Plast Reconstr Surg Glob Open2020;8:e2675 PMCID:PMC7253262

[17]

Scaglioni MF,Chen YC,Chia-Shen Yang J.Comprehensive review of vascularized lymph node transfers for lymphedema: Outcomes and complications.Microsurgery2018;38:222-9

[18]

Koshima I,Urushibara K.Supermicrosurgical lymphaticovenular anastomosis for the treatment of lymphedema in the upper extremities.J Reconstr Microsurg2000;16:437-42

[19]

Sisk GC,Lopez M.Lymphovenous anastomosis using the venous coupler.J Plast Reconstr Aesthet Surg2020;73:983-1007

[20]

Chang EI,Chang EI.Advancements in imaging technology for microvascular free tissue transfer.J Surg Oncol2018;118:729-35

[21]

Yamamoto T,Doi K.Indocyanine green-enhanced lymphography for upper extremity lymphedema: a novel severity staging system using dermal backflow patterns.Plast Reconstr Surg2011;128:941-7

[22]

Pons G,Alomar X,Tom LK.Preoperative planning of lymphaticovenous anastomosis: the use of magnetic resonance lymphangiography as a complement to indocyanine green lymphography.J Plast Reconstr Aesthet Surg2019;72:884-91

[23]

Zeltzer AA,Koning M.MR lymphography in patients with upper limb lymphedema: The GPS for feasibility and surgical planning for lympho-venous bypass.J Surg Oncol2018;118:407-15

[24]

Bianchi A,Hayashi A,Longo V.Ultra-high frequency ultrasound imaging of lymphatic channels correlates with their histological features: A step forward in lymphatic surgery.J Plast Reconstr Aesthet Surg2020;73:1622-9

[25]

Cha HG,Cho MJ.Changing the paradigm: lymphovenous anastomosis in advanced stage lower extremity lymphedema.Plast Reconstr Surg2021;147:199-207

[26]

Johnson AR,Granoff MD.Evaluating the impact of immediate lymphatic reconstruction for the surgical prevention of lymphedema.Plast Reconstr Surg2021;147:373e-81e

[27]

Cook JA,Loewenstein SN.Immediate lymphatic reconstruction after axillary lymphadenectomy: a single-institution early experience.Ann Surg Oncol2021;28:1381-7

[28]

Squitieri L,Patel KM.An economic analysis of prophylactic lymphovenous anastomosis among breast cancer patients receiving mastectomy with axillary lymph node dissection.J Surg Oncol2020;121:1175-8

[29]

Schwarz GS,Djohan RS.Axillary reverse mapping and lymphaticovenous bypass: lymphedema prevention through enhanced lymphatic visualization and restoration of flow.J Surg Oncol2019;120:160-7

[30]

Boccardo F,De Cian F.Lymphatic microsurgical preventing healing approach (LYMPHA) for primary surgical prevention of breast cancer-related lymphedema: over 4 years follow-up.Microsurgery2014;34:421-4

[31]

Coriddi M,Meyerson J,Skoracki R.Vascularized jejunal mesenteric lymph node transfer: a novel surgical treatment for extremity lymphedema.J Am Coll Surg2017;225:650-7

[32]

Gustafsson J,Chan WH.Correlation between quantity of transferred lymph nodes and outcome in vascularized submental lymph node flap transfer for lower limb lymphedema.Plast Reconstr Surg2018;142:1056-63

[33]

Nguyen AT,Hanasono MM,Wong FC.Long-term outcomes of the minimally invasive free vascularized omental lymphatic flap for the treatment of lymphedema.J Surg Oncol2017;115:84-9

[34]

Maldonado AA,Chang DW.The use of supraclavicular free flap with vascularized lymph node transfer for treatment of lymphedema: a prospective study of 100 consecutive cases.J Surg Oncol2017;115:68-71

[35]

Ciudad P,Perez Coca JJ.Comparison of long-term clinical outcomes among different vascularized lymph node transfers: 6-year experience of a single center's approach to the treatment of lymphedema.J Surg Oncol2017;116:671-82

[36]

Massey MF.The incidence of donor-site morbidity after transverse cervical artery vascularized lymph node transfers: the need for a lymphatic surgery national registry.Plast Reconstr Surg2015;135:939e-40e

[37]

Lee M,Reinertsen E.Lymphedema of the upper extremity following supraclavicular lymph node harvest.Plast Reconstr Surg2015;135:1079e-82e PMCID:PMC4667721

[38]

Chu CK,Chang EI,Hanasono MM.Intra-abdominal lymph nodes: a privileged donor site for vascularized lymph node transfer.Plast Reconstr Surg Glob Open2020;8:e2673 PMCID:PMC7253245

[39]

Manrique OJ,Kuruoglu D.Gastroepiploic lymph node flap harvest for patients with lymphedema: minimally invasive versus open approach.Ann Plast Surg2020;85:S87-91

[40]

Nguyen AT.Laparoscopic free omental lymphatic flap for the treatment of lymphedema.Plast Reconstr Surg2015;136:114-8

[41]

Nguyen AT,Suami H.An algorithmic approach to simultaneous vascularized lymph node transfer with microvascular breast reconstruction.Ann Surg Oncol2015;22:2919-24

[42]

Schaverien MV.Combined deep inferior epigastric artery perforator flap with vascularized groin lymph node transplant for treatment of breast cancer-related lymphedema.Gland Surg2021;10:460-8 PMCID:PMC7882306

[43]

Pons G,Sarria J,Masia J.Reverse lymph node mapping using indocyanine green lymphography: a step forward in minimizing donor-site morbidity in vascularized lymph node transfer.Plast Reconstr Surg2021;147:207e-12e

[44]

Hamdi M,De Baerdemaeker R.Decreasing donor site morbidity after groin vascularized lymph node transfer with lessons learned from a 12-year experience and review of the literature.J Plast Reconstr Aesthet Surg2021;74:540-8

[45]

Chang EI,Liu J.Optimizing quality of life for patients with breast cancer-related lymphedema: a prospective study combining DIEP flap breast reconstruction and lymphedema surgery.Plast Reconstr Surg2020;145:676e-85e

[46]

Chang EI,Hanson SE,Hanasono MM.Evolution in surgical management of breast cancer-related lymphedema: the MD Anderson cancer center experience.Plast Reconstr Surg Glob Open2020;8:e2674 PMCID:PMC7253265

[47]

Masia J,Nardulli ML.Combined surgical treatment in breast cancer-related lymphedema.J Reconstr Microsurg2016;32:16-27

[48]

Hanson SE,Schaverien MV,Selber JC.Controversies in surgical management of lymphedema.Plast Reconstr Surg Glob Open2020;8:e2671 PMCID:PMC7253258

[49]

Beederman M,Agarwal S.Outcomes for physiologic microsurgical treatment of secondary lymphedema involving the extremity.Ann Surg2020;

[50]

Di Taranto G,Chen SH.A prospective study on combined lymphedema surgery: Gastroepiploic vascularized lymph nodes transfer and lymphaticovenous anastomosis followed by suction lipectomy.Microsurgery2021;41:34-43

[51]

Yamamoto T,Kageyama T,Fuse Y.Lymph-interpositional-flap transfer (LIFT) based on lymph-axiality concept: simultaneous soft tissue and lymphatic reconstruction without lymph node transfer or lymphatic anastomosis.J Plast Reconstr Aesthet Surg2021;S1748-6815(21)00104

[52]

Yamamoto T,Yoshimatsu H,Hayashi A.Lymph flow restoration after tissue replantation and transfer: importance of lymph axiality and possibility of lymph flow reconstruction without lymph node transfer or lymphatic anastomosis.Plast Reconstr Surg2018;142:796-804

[53]

Chang DW.Lymphaticovenular bypass for lymphedema management in breast cancer patients: a prospective study.Plast Reconstr Surg2010;126:752-8

[54]

Chen R,Zhang H.Simultaneous breast reconstruction and treatment of breast cancer-related upper arm lymphedema with lymphatic lower abdominal flap.Ann Plast Surg2014;73 Suppl 1:S12-7

[55]

Saaristo AM,Viitanen TP,Hartiala P.Microvascular breast reconstruction and lymph node transfer for postmastectomy lymphedema patients.Ann Surg2012;255:468-73

[56]

Cheng MH,Chen C,Pappalardo M.Simultaneous ipsilateral vascularized lymph node transplantation and contralateral lymphovenous anastomosis in bilateral extremity lymphedema with different severities.Ann Surg Oncol2020;27:5267-76 PMCID:PMC7669763

[57]

Hassan K.The charles procedure as part of the modern armamentarium against lymphedema.Ann Plast Surg2020;85:e37-43

[58]

Sapountzis S,Lim SY.Modified Charles procedure and lymph node flap transfer for advanced lower extremity lymphedema.Microsurgery2014;34:439-47

[59]

Brorson H.Liposuction in lymphedema treatment.J Reconstr Microsurg2016;32:56-65

[60]

Boyages J,Koelmeyer LA.Liposuction for advanced lymphedema: a multidisciplinary approach for complete reduction of arm and leg swelling.Ann Surg Oncol2015;22 Suppl 3:S1263-70 PMCID:PMC4686553

[61]

Greene AK,Maclellan RA.Liposuction for swelling in patients with lymphedema.N Engl J Med2017;377:1788-9

[62]

Chang EI,El-ftesi S.Tissue engineering using autologous microcirculatory beds as vascularized bioscaffolds.FASEB J2009;23:906-15 PMCID:PMC2653982

[63]

Lähteenvuo M,Tervala T.Growth factor therapy and autologous lymph node transfer in lymphedema.Circulation2011;123:613-20

[64]

Hartiala P,Suominen E.Phase 1 Lymfactin® Study: short-term safety of combined adenoviral VEGF-C and lymph node transfer treatment for upper extremity lymphedema.J Plast Reconstr Aesthet Surg2020;73:1612-21

[65]

Honkonen KM,Tervala TV.Lymph node transfer and perinodal lymphatic growth factor treatment for lymphedema.Ann Surg2013;257:961-7

[66]

Tammela T.Lymphangiogenesis: molecular mechanisms and future promise.Cell2010;140:460-76

[67]

Rochlin DH,Zelones J.The role of adjunct nanofibrillar collagen scaffold implantation in the surgical management of secondary lymphedema: Review of the literature and summary of initial pilot studies.J Surg Oncol2020;121:121-8

[68]

Classen DA.Free muscle flap transfer as a lymphatic bridge for upper extremity lymphedema.J Reconstr Microsurg2005;21:93-9

[69]

Rockson SG.Lymphedema after breast cancer treatment.N Engl J Med2018;379:1937-44

[70]

Rockson SG,Jiang X.Pilot studies demonstrate the potential benefits of antiinflammatory therapy in human lymphedema.JCI Insight2018;3:123775 PMCID:PMC6237444

[71]

Johnson AR,Granoff MD.Is immediate lymphatic reconstruction cost-effective?.Ann Surg2019;

[72]

Boccardo F,Costantini S.LYMPHA technique to prevent secondary lower limb lymphedema.Ann Surg Oncol2016;23:3558-63

[73]

Beelen LM,Tsangaris E.Patient-reported outcome measures in lymphedema: a systematic review and COSMIN analysis.Ann Surg Oncol2021;28:1656-68

[74]

Fish ML,Schwarz GS.Quality-of-Life outcomes in surgical vs nonsurgical treatment of breast cancer-related lymphedema: a systematic review.JAMA Surg2020;155:513-9

PDF

81

Accesses

0

Citation

Detail

Sections
Recommended

/