A personalized nutrition plan based on genetic profile improves outcomes of facial regeneration with Platelet-Rich Fibrin liquid matrices

Abstract

Aim: The importance of nutrition in the prevention of skin aging has been shown by large observational studies. However, there are no studies assessing dietary changes as adjunct procedures to aesthetic interventions. The objective of this study was to assess whether a personalized nutritional plan conveys additional benefits to platelet-rich fibrin (PRF) facial regeneration.

Methods: Forty-seven healthy women (mean age 52.5 years old, SD = 7.7) were offered minimally invasive facial regeneration with the use of PRF liquid matrices, as well as a personalized nutritional plan. The nutritional plan was informed by a nutrigenetic test based on 128 polymorphisms. Horizontal forehead lines, zygomatic wrinkles or mid-cheek furrows, nasolabial folds, perioral expression wrinkles, and marionette line were assessed separately with the use of the Facial Wrinkles Assessment Scale (FWAS).

Results: The total FWAS score change was statistically significantly better in women who reported an at least partial adaptation of nutritional recommendations for at least three months (Z = 2.4, P = 0.008).

Conclusion: Personalized nutritional recommendations based on individual needs as well as generally accepted dietary guidelines can improve treatment outcomes of minimally invasive facial skin aesthetics interventions.

Keywords

Platelet-rich fibrin / nutrigenetics / facial skin aesthetics

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