Autologous platelet rich plasma - an adjunct to early tangential excision and grafting in burns

Abstract

Aim: To affirm that autologous platelet rich plasma is a useful adjunct to early tangential excision and skin grafting to enhance wound epithelization rates and improve scar quality.

Methods: The study was conducted in JIPMER Tertiary Burn Care Centerfrom November 2017 to February 2018. The study was purely descriptive in nature and no statistical analysis was performed. A total of 12 patients were included with burn wounds involving 10% to 25% total body surface area.

Results: There was 100% epithelization noted at the end of 2 weeks for all the 12 participants. Skin graft take was faster with mean 85.4% take for all the 12 patients within 5 days.

Conclusion: Since it is an autologous component, platelet rich plasma is extremely safe and free of antigenic components. It is relatively simple to prepare, less time taking, cost effective and highly efficacious in improving wound healing and improving the efficacy of the traditional techniques like tangential excision and skin grafting in burn patients.

Keywords

Autologous platelet rich plasma / burns / tangential excision / split skin grafting

References

[1] Gupta JL,Bajaj SP.National programme for prevention of burn injuries..Indian J Plast Surg2010;43:S6-10 PMCID:PMC3038407

[2] Janzekovic Z.The burn wound from the surgical point of view..J Trauma1975;15:42-62

[3] Hunt JL,Baxter CR.Early tangential excision and immediate mesh autografting of deep dermal hand burns..Ann Surg1979;189:147-51 PMCID:PMC1397028

[4] Everts PA,Weibrich G,Hoffmann J.Platelet-rich plasma and platelet gel: a review..J Extra Corpor Technol2006;38:174-87 PMCID:PMC4680757

[5] Eppley BL,Higgins J.Platelet quantification and growth factor analysis from platelet-rich plasma: implications for wound healing..Plast Reconstr Surg2004;114:1502-8

[6] Eppley BL,Blanton M.Platelet-rich plasma: a review of biology and applications in plastic surgery..Plast Reconstr Surg2006;118:147e-59e

[7] Sánchez-González DJ,Trejo-Bahena NI.Platelet-rich plasma peptides: key for regeneration..Int J Pept2012;2012:532519 PMCID:PMC3303558

[8] El-Sharkawy H,Deady J,Liu H.Platelet-rich plasma: growth factors and pro- and anti-inflammatory properties..J Periodontol2007;78:661-9

[9] Pallua N,Markowicz M.Platelet-rich plasma in burns..Burns2010;36:4-8

[10] Choi HN,Kim SR,Kim H.The effect of platelet-rich plasma on survival of the composite graft and the proper time of injection in a rabbit ear composite graft model..Arch Plast Surg2014;41:647-53 PMCID:PMC4228205