REVIEW

“Sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interaction

  • Haonan Zheng 1,2 ,
  • Cunzheng Zhang 1,2 ,
  • Jindong Zhang 1,2 ,
  • Liping Duan , 1,2
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  • 1. Department of Gastroenterology, Peking University Third Hospital, Beijing 100191, China
  • 2. Beijing Key Laboratory for Helicobacter Pylori Infection and Upper Gastrointestinal Diseases, Beijing 100191, China
duanlp@bjmu.edu.cn

Received date: 22 Feb 2023

Accepted date: 06 Apr 2023

Copyright

2023 The Author(s) 2023. Published by Oxford University Press on behalf of Higher Education Press.

Abstract

Abnormal brain–gut interaction is considered the core pathological mechanism behind the disorders of gut–brain interaction (DGBI), in which the intestinal microbiota plays an important role. Microglia are the “sentinels” of the central nervous system (CNS), which participate in tissue damage caused by traumatic brain injury, resist central infection and participate in neurogenesis, and are involved in the occurrence of various neurological diseases. With in-depth research on DGBI, we could find an interaction between the intestinal microbiota and microglia and that they are jointly involved in the occurrence of DGBI, especially in individuals with comorbidities of mental disorders, such as irritable bowel syndrome (IBS). This bidirectional regulation of microbiota and microglia provides a new direction for the treatment of DGBI. In this review, we focus on the role and underlying mechanism of the interaction between gut microbiota and microglia in DGBI, especially IBS, and the corresponding clinical application prospects and highlight its potential to treat DGBI in individuals with psychiatric comorbidities.

Cite this article

Haonan Zheng , Cunzheng Zhang , Jindong Zhang , Liping Duan . “Sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interaction[J]. Protein & Cell, 2023 , 14(10) : 726 -742 . DOI: 10.1093/procel/pwad020

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