LETTER

Structure basis for allosteric regulation of lymphocytic choriomeningitis virus polymerase function by Z matrix protein

  • Lu Liu 1 ,
  • Panpan Wang 2 ,
  • Aijun Liu 3 ,
  • Leike Zhang 4 ,
  • Liming Yan 1 ,
  • Yu Guo , 5 ,
  • Gengfu Xiao , 4 ,
  • Zihe Rao , 1,5,6,7,8 ,
  • Zhiyong Lou , 1
Expand
  • 1. MOE Key Laboratory of Protein Science, School of Medicine, Tsinghua University, Beijing 100084, China
  • 2. School of Life Sciences, Peking University, Beijing 100080, China
  • 3. Kobilka Institute of Innovative Drug Discovery, School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen 518100, China
  • 4. State key laboratory of Virology and National Virus Resource Center, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, China
  • 5. State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences and College of Pharmacy, Nankai University, Tianjin 300350, China
  • 6. National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100105, China
  • 7. Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai 200120, China
  • 8. Innovation Center for Pathogen Research, Guangzhou Laboratory, Guangzhou 510005, China
guoy@nankai.edu.cn
xiaogf@wh.iov.cn
raozh@tsinghua.edu.cn
louzy@mail.tsinghua.edu.cn

Accepted date: 29 Mar 2023

Copyright

2023 The Author(s) 2023. Published by Oxford University Press on behalf of Higher Education Press.

Cite this article

Lu Liu , Panpan Wang , Aijun Liu , Leike Zhang , Liming Yan , Yu Guo , Gengfu Xiao , Zihe Rao , Zhiyong Lou . Structure basis for allosteric regulation of lymphocytic choriomeningitis virus polymerase function by Z matrix protein[J]. Protein & Cell, 2023 , 14(9) : 703 -707 . DOI: 10.1093/procel/pwad018

1
Abdella R, Aggarwal M, Okura T et al. Structure of a paramyxovirus polymerase complex reveals a unique methyltransferase-CTD conformation. Proc Natl Acad Sci USA 2020;117:4931–4941.

DOI

2
Borden KL, Campbell Dwyer EJ, Salvato MS. An arenavirus RING (zinc-binding) protein binds the oncoprotein promyelocyte leukemia protein (PML) and relocates PML nuclear bodies to the cytoplasm. J Virol 1998;72:758–766.

DOI

3
Cornu TI, de la Torre JC. Characterization of the arenavirus RING finger Z protein regions required for Z-mediated inhibition of viral RNA synthesis. J Virol 2002;76:6678–6688.

DOI

4
de la Torre JC. Molecular and cell biology of the prototypic arenavirus LCMV: implications for understanding and combating hemorrhagic fever arenaviruses. Ann N Y Acad Sci 2009;1171(Suppl 1):E57–E64.

DOI

5
Gerlach P, Malet H, Cusack S et al. Structural insights into Bunyavirus replication and its regulation by the vRNA promoter. Cell 2015;161:1267–1279.

DOI

6
Hastie KM, Zandonatti M, Liu T et al. Crystal structure of the oligomeric form of Lassa virus matrix protein Z. J Virol 2016;90:4556–4562.

DOI

7
Horwitz JA, Jenni S, Harrison SC et al. Structure of a rabies virus polymerase complex from electron cryo-microscopy. Proc Natl Acad Sci USA 2020;117:2099–2107.

DOI

8
Kranzusch PJ, Schenk AD, Rahmeh AA et al. Assembly of a functional Machupo virus polymerase complex. Proc Natl Acad Sci USA 2010;107:20069–20074.

DOI

9
Lehmann M, Pahlmann M, Jerome H et al. Role of the C terminus of Lassa virus L protein in viral mRNA synthesis. J Virol 2014;88:8713–8717.

DOI

10
Liang B, Li Z, Jenni S et al. Structure of the L protein of vesicular stomatitis virus from electron cryomicroscopy. Cell 2015;162:314–327.

DOI

11
Palacios G, Druce J, Du L et al. A new arenavirus in a cluster of fatal transplant-associated diseases. N Engl J Med 2008;358:991–998.

DOI

12
Pan J, Qian X, Lattmann S et al. Structure of the human metapneumovirus polymerase phosphoprotein complex. Nature 2020;577:275–279.

DOI

13
Peng R, Xu X, Jing J et al. Structural insight into arenavirus replication machinery. Nature 2020;579:615–619.

DOI

14
Pyle JD, Whelan SPJ. RNA ligands activate the Machupo virus polymerase and guide promoter usage. Proc Natl Acad Sci USA 2019;116:10518–10524.

DOI

15
Volpon L, Osborne MJ, Capul AA et al. Structural characterization of the Z RING-eIF4E complex reveals a distinct mode of control for eIF4E. Proc Natl Acad Sci USA 2010;107:5441–5446.

DOI

Outlines

/