Protein & Cell >

2023 , Vol. 14 >Issue 1: 74 - 78

DOI: https://doi.org/10.1093/procel/pwac042

LETTER

A core epitope targeting antibody of SARS-CoV-2

  • Simeng Zhao 1 ,
  • Fengjiang Liu 2,3 ,
  • Shizhen Qiu 4 ,
  • Qiaoshuai Lan 5 ,
  • Yiran Wu 1 ,
  • Wei Xu 5 ,
  • Junzi Ke 1,4 ,
  • Jie Yang 1,4 ,
  • Xiaoyan Liu 1 ,
  • Kun Wang 4 ,
  • Hangtian Guo 2 ,
  • Shuai Xia 5 ,
  • Fangfang Zhang 1 ,
  • Jiabei Wang 6 ,
  • Xiaowen Hu 7 ,
  • Lu Lu 5 ,
  • Shibo Jiang 5 ,
  • Suwen Zhao 1,4 ,
  • Lianxin Liu , 8 ,
  • Youhua Xie , 5 ,
  • Xiuna Yang , 2 ,
  • Haopeng Wang , 4 ,
  • Guisheng Zhong , 1,4
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  • 1. iHuman Institute, ShanghaiTech University, Shanghai 201210, China
  • 2. Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China
  • 3. Innovative Center for Pathogen Research, Guangzhou Laboratory, Guangzhou 510005, China
  • 4. School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China
  • 5. Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS), School of Basic Medical Sciences and Biosafety Level
  • 6. Laboratory, Fudan University, Shanghai 200032, China
  • 7. Department of Hepatobiliary Surgery, Anhui Province Key Laboratory of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, The University of Science and Technology of China, Hefei 230001, China
  • 8. Department of Pulmonary and Critical Care Medicine, Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, The University of Science and Technology of China, Hefei 230026, China
  • 9. Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, The University of Sciences and Technology of China, Hefei 230001, China

Accepted date: 30 Sep 2022

Copyright

2022 The Author(s) 2022. Published by Oxford University Press on behalf of Higher Education Press.
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Cite this article

Simeng Zhao , Fengjiang Liu , Shizhen Qiu , Qiaoshuai Lan , Yiran Wu , Wei Xu , Junzi Ke , Jie Yang , Xiaoyan Liu , Kun Wang , Hangtian Guo , Shuai Xia , Fangfang Zhang , Jiabei Wang , Xiaowen Hu , Lu Lu , Shibo Jiang , Suwen Zhao , Lianxin Liu , Youhua Xie , Xiuna Yang , Haopeng Wang , Guisheng Zhong . A core epitope targeting antibody of SARS-CoV-2[J]. Protein & Cell, 2023 , 14(1) : 74 -78 . DOI: 10.1093/procel/pwac042

References

Publishing order | Descend order by publishing year | Descend order by cited within
1
Baum A , Fulton BO , Wloga E et al. Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies. Science 2020; 369: 1014- 1018.

2
Cao Y , Su B , Guo X et al. Potent neutralizing antibodies against SARS-CoV-2 identified by high-throughput single-cell sequencing of convalescent patients’ B cells. Cell 2020; 182: 73- 84.e16.

3
Chen RE , Zhang X , Case JB et al. Resistance of SARS-CoV-2 variants to neutralization by monoclonal and serum-derived polyclonal antibodies. Nat Med 2021; 27: 717- 726.

4
Du S , Cao Y , Zhu Q et al. Structurally resolved SARS-CoV-2 antibody shows high efficacy in severely infected hamsters and provides a potent cocktail pairing strategy. Cell 2020; 183: 1013- 1023.e13.

5
Hansen J , Baum A , Pascal KE et al. Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail. Science 2020; 369: 1010- 1014.

6
Lan J , Ge J , Yu J et al. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature 2020; 581: 215- 220.

7
Li Q , Wu J , Nie J et al. The impact of mutations in SARS-CoV-2 spike on viral infectivity and antigenicity. Cell 2020; 182: 1284- 1294.e9.

8
Sampah ME , Shen L , Jilek BL et al. Dose-response curve slope is a missing dimension in the analysis of HIV-1 drug resistance. Proc Natl Acad Sci USA 2011; 108: 7613- 7618.

9
Shi R , Shan C , Duan X et al. A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2. Nature 2020; 584: 120- 124.

10
Starr TN , Greaney AJ , Hilton SK et al. Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding. Cell 2020; 182: 1295- 1310.e20.

11
Tortorici MA , Beltramello M , Lempp FA et al. Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms. Science 2020; 370: 950- 957.

12
Wang P , Nair MS , Liu L et al. Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7. Nature 2021; 593: 130- 135.

13
Webb NE , Montefiori DC , Lee B . Dose-response curve slope helps predict therapeutic potency and breadth of HIV broadly neutralizing antibodies. Nat Commun 2015; 6: 8443.

14
Wrapp D , Wang N , Corbett KS et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science 2020; 367: 1260- 1263.

15
Yurkovetskiy L , Wang X , Pascal KE et al. Structural and functional analysis of the D614G SARS-CoV-2 spike protein variant. Cell 2020; 183: 739- 751.e8.

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