Protein & Cell >

2021 , Vol. 12 >Issue 10: 751 - 755

DOI: https://doi.org/10.1007/s13238-020-00807-6

HIGHLIGHT

Single cell RNA and immune repertoire profiling of COVID-19 patients reveal novel neutralizing antibody

  • Fang Li 1 ,
  • Meng Luo 2 ,
  • Wenyang Zhou 2 ,
  • Jinliang Li 3 ,
  • Xiyun Jin 2 ,
  • Zhaochun Xu 2 ,
  • Liran Juan 2 ,
  • Zheng Zhang 3 ,
  • Yuou Li 3 ,
  • Renqiang Liu 1 ,
  • Yiqun Li 2 ,
  • Chang Xu 2 ,
  • Kexin Ma 2 ,
  • Huimin Cao 2 ,
  • Jingwei Wang 3 ,
  • Pingping Wang , 2 ,
  • Zhigao Bu , 1 ,
  • Qinghua Jiang , 2,4
Expand
  • 1. State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, China
  • 2. School of Life Science and Technology, Harbin Institute of Technology, Harbin 150000, China
  • 3. Harbin Sixth Hospital, Harbin 150000, China
  • 4. Key Laboratory of Biological Big Data (Harbin Institute of Technology), Ministry of Education, Harbin 150001, China

Accepted date: 29 Oct 2020

Published date: 15 Oct 2021

Copyright

2020 The Author(s) 2020
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Cite this article

Fang Li , Meng Luo , Wenyang Zhou , Jinliang Li , Xiyun Jin , Zhaochun Xu , Liran Juan , Zheng Zhang , Yuou Li , Renqiang Liu , Yiqun Li , Chang Xu , Kexin Ma , Huimin Cao , Jingwei Wang , Pingping Wang , Zhigao Bu , Qinghua Jiang . Single cell RNA and immune repertoire profiling of COVID-19 patients reveal novel neutralizing antibody[J]. Protein & Cell, 2021 , 12(10) : 751 -755 . DOI: 10.1007/s13238-020-00807-6

References

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1
Cai J, Sun W, Huang J, Gamber M, Wu J, He G (2020) Indirect virus transmission in cluster of COVID-19 cases, Wenzhou, China, 2020. Emerg Infect Dis J 26(6):1343–1345

DOI

2
Cao Y, Su B, Guo X, Sun W, Deng Y, Bao L, Zhu Q, Zhang X, Zheng Y, Geng C (2020) Potent neutralizing antibodies against SARS-CoV-2 identified by high-throughput single-cell sequencing of convalescent patients’ B cells. Cell 182:73-84.e16

DOI

3
Gitlin AD, von Boehmer L, Gazumyan A, Shulman Z, Oliveira TY, Nussenzweig MC (2016) Independent roles of switching and hypermutation in the development and persistence of B lymphocyte memory. Immunity 44:769–781

DOI

4
Hu X, Zhang J, Wang J, Fu J, Li T, Zheng X, Wang B, Gu S, Jiang P, Fan J (2019) Landscape of B cell immunity and related immune evasion in human cancers. Nat Genet 51:560–567

DOI

5
Lv Z, Deng Y-Q, Ye Q, Cao L, Sun C-Y, Fan C, Huang W, Sun S, Sun Y, Zhu L (2020) Structural basis for neutralization of SARSCoV-2 and SARS-CoV by a potent therapeutic antibody. Science 369:1505–1509

DOI

6
Palladino G, Mozdzanowska K, Washko G, Gerhard W (1995) Virusneutralizing antibodies of immunoglobulin G (IgG) but not of IgM or IgA isotypes can cure influenza virus pneumonia in SCID mice. J Virol 69:2075–2081

DOI

7
Thevarajan I, Nguyen THO, Koutsakos M, Druce J, Caly L, van de Sandt CE, Jia X, Nicholson S, Catton M, Cowie B (2020) Breadth of concomitant immune responses prior to patient recovery: a case report of non-severe COVID-19. Nat Med 26:453–455

DOI

8
Wang J, Shuai L, Wang C, Liu R, He X, Zhang X, Sun Z, Shan D, Ge J, Wang X(2020) Mouse-adapted SARS-CoV-2 replicates efficiently in the upper and lower respiratory tract of BALB/c and C57BL/6J mice. Protein Cell 11(10):1–7

DOI

9
Wu S, Zhong G, Zhang J, Shuai L, Zhang Z, Wen Z, Wang B, Zhao Z, Song X, Chen Y(2020) A single dose of an adenovirusvectored vaccine provides protection against SARS-CoV-2 challenge. Nat Commun 11:4081

DOI

10
Zou Q, Hu Q, Guo M, Wang G (2015) HAlign: fast multiple similar DNA/RNA sequence alignment based on the centre star strategy. Bioinformatics 31:2475–2481

DOI

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