Protein & Cell >

2020 , Vol. 11 >Issue 10: 771 - 775

DOI: https://doi.org/10.1007/s13238-020-00718-6

LETTER

Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids

  • Bing Zhao , 1 ,
  • Chao Ni 1 ,
  • Ran Gao 2 ,
  • Yuyan Wang 3 ,
  • Li Yang 1 ,
  • Jinsong Wei 1 ,
  • Ting Lv 4 ,
  • Jianqing Liang 1 ,
  • Qisheng Zhang 5 ,
  • Wei Xu 3 ,
  • Youhua Xie 3 ,
  • Xiaoyue Wang 2 ,
  • Zhenghong Yuan 3 ,
  • Junbo Liang , 2 ,
  • Rong Zhang , 3 ,
  • Xinhua Lin , 1
Expand
  • 1. State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai 200438, China
  • 2. State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China
  • 3. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China
  • 4. Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China
  • 5. Sino Organoid Lifesciences Ltd., Shanghai 201900, China

Published date: 15 Oct 2020

Copyright

2020 The Author(s) 2020
Fold

Cite this article

Bing Zhao , Chao Ni , Ran Gao , Yuyan Wang , Li Yang , Jinsong Wei , Ting Lv , Jianqing Liang , Qisheng Zhang , Wei Xu , Youhua Xie , Xiaoyue Wang , Zhenghong Yuan , Junbo Liang , Rong Zhang , Xinhua Lin . Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids[J]. Protein & Cell, 2020 , 11(10) : 771 -775 . DOI: 10.1007/s13238-020-00718-6

References

Publishing order | Descend order by publishing year | Descend order by cited within
1
Chai X, Hu L, Zhang Y, Han W, Lu Z, Ke A, Zhou J, Shi G, Fang N, Fan J, (2020) Specific ACE2 expression in cholangiocytes may cause liver damage after 2019-nCoV infection. bioRxiv

DOI

2
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y (2020) Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet 395:507–513

DOI

3
Dutta D, Clevers H (2017) Organoid culture systems to study hostpathogen interactions. Curr Opin Immunol 48:15–22

DOI

4
Fan Z, Chen L, Li J, Tian C, Zhang Y, Huang S, Liu Z, Cheng J (2020) Clinical features of COVID-19 related liver damage. medRxiv

DOI

5
Hoffmann M, Kleine-Weber H, Schroeder S, Kruger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, (2020) SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell

DOI

6
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G, Xu J, Gu X (2020) Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 395:497–506

DOI

7
Huch M, Gehart H, van Boxtel R, Hamer K, Blokzijl F, Verstegen MM, Ellis E, van Wenum M, Fuchs SA, de Ligt J (2015) Long-term culture of genome-stable bipotent stem cells from adult human liver. Cell 160:299–312

DOI

8
Kuhn JH, Li W, Choe H, Farzan M (2004) Angiotensin-converting enzyme 2: a functional receptor for SARS coronavirus. Cell Mol Life Sci 61:2738–2743

DOI

9
Qi F, Qian S, Zhang S, Zhang Z (2020) Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses. bioRxiv

DOI

10
Wan, Y., Shang, J., Graham, R., Baric , R.S., and Li, F. (2020). Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus. J Virol94.

DOI

11
Wu F, Zhao S, Yu B, Chen YM, Wang W, Song ZG, Hu Y, Tao ZW, Tian JH, Pei YY (2020) A new coronavirus associated with human respiratory disease in China. Nature 579:265–269

DOI

12
Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, Liu S, Zhao P, Liu H, Zhu L, (2020) Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med

DOI

13
Zhang H, Kang Z, Gong H, Xu D, Wang J, Li Z, Cui X, Xiao J, Meng T, Zhou W, (2020) The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes. bioRxiv

DOI

14
Zhao, Y., Zhao, Z., Wang, Y., Zhou , Y., Ma, Y., and Zuo, W. (2020). Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov. bioRxiv.

DOI

15
Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R (2020) A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 382:727–733

DOI

Options
Outlines

/

〈 〉