Protein & Cell >

2020 , Vol. 11 >Issue 11: 846 - 851

DOI: https://doi.org/10.1007/s13238-020-00709-7

LETTER

SIRT5 is important for bacterial infection by regulating insulin secretion and glucose homeostasis

  • Cuiping Zhang 1,2 ,
  • Ke Wang 1 ,
  • Zuojian Hu 2 ,
  • Lujie Yang 1 ,
  • Bin Wei 3 ,
  • Shan Li 2 ,
  • Xue Qin 2 ,
  • Pengyuan Yang , 1,5 ,
  • Hongxiu Yu , 1,4
Expand
  • 1. Minhang Hospital Institutes of Biomedical Sciences, Department of Systems Biology for Medicine, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
  • 2. Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China
  • 3. School of Life Science, Shanghai University, Shanghai 200444, China
  • 4. Minhang Hospital Institutes of Biomedical Sciences, Department of Systems Biology for Medicine, School of Basic Medical Sciences, Fudan University, Room 501, Mingdao Building, 131 Dongan Road, Shanghai 200032, China
  • 5. Minhang Hospital Institutes of Biomedical Sciences, Department of Systems Biology for Medicine, School of Basic Medical Sciences, Fudan University, Room 201, Mingdao Building, 131 Dongan Road, Shanghai 200032, China

Published date: 15 Nov 2020

Copyright

2020 The Author(s) 2020
Fold

Cite this article

Cuiping Zhang , Ke Wang , Zuojian Hu , Lujie Yang , Bin Wei , Shan Li , Xue Qin , Pengyuan Yang , Hongxiu Yu . SIRT5 is important for bacterial infection by regulating insulin secretion and glucose homeostasis[J]. Protein & Cell, 2020 , 11(11) : 846 -851 . DOI: 10.1007/s13238-020-00709-7

References

Publishing order | Descend order by publishing year | Descend order by cited within
1
Dror E, Dalmas E, Meier DT, Wueest S, Thevenet J, Thienel C, Timper K, Nordmann TM, Traub S, Schulze F (2017) Postprandial macrophage-derived IL-1beta stimulates insulin, and both synergistically promote glucose disposal and inflammation. Nat Immunol 18:283–292

DOI

2
Hajmrle C, Smith N, Spigelman AF, Dai X, Senior L, Bautista A, Ferdaoussi M, MacDonald PE (2016) Interleukin-1 signaling contributes to acute islet compensation. JCI Insight 1:e86055

DOI

3
Hao H, Cao L, Jiang C, Che Y, Zhang S, Takahashi S, Wang G, Gonzalez FJ (2017) Farnesoid X receptor regulation of the NLRP3 inflammasome underlies cholestasis-associated sepsis. Cell Metab 25(856–867):e855

DOI

4
Heinonen T,Ciarlo E, Theroude C, Pelekanou A,Herderschee J, LeRoy D, Roger T (2018) Sirtuin 5 deficiency does not compromise innate immune responses to bacterial infections. Front Immunol 9:2675

DOI

5
Liu TF, Vachharajani VT, Yoza BK, McCall CE (2012) NAD+-dependent sirtuin 1 and 6 proteins coordinate a switch from glucose to fatty acid oxidation during the acute inflammatory response. J Biol Chem 287:25758–25769

DOI

6
Norata GD, Caligiuri G, Chavakis T, Matarese G, Netea MG, Nicoletti A, O’Neill LA, Marelli-Berg FM (2015) The cellular and molecular basis of translational immunometabolism. Immunity 43:421–434

DOI

7
Schroder K, Tschopp J (2010) The inflammasomes. Cell 140:821–832

DOI

8
Sestan M, Marinovic S, Kavazovic I, Cekinovic D, Wueest S, Turk Wensveen T, Brizic I, Jonjic S, Konrad D, Wensveen FM (2018) Virus-induced interferon-gamma causes insulin resistance in skeletal muscle and derails glycemic control in obesity. Immunity 49(164–177):e166

DOI

9
Ting JP,Willingham SB,Bergstralh DT(2008)NLRs at the intersection of cell death and immunity. Nat Rev Immunol 8:372–379

DOI

10
Tsai S, Clemente-Casares X, Zhou AC, Lei H, Ahn JJ, Chan YT, Choi O, Luck H, Woo M, Dunn SE (2018) Insulin receptormediated stimulation boosts T cell immunity during inflammation and infection. Cell Metab 28(922–934):e924

DOI

11
Tucey TM, Verma J, Harrison PF, Snelgrove SL, Lo TL, Scherer AK, Barugahare AA, Powell DR, Wheeler RT, Hickey MJ (2018) glucose homeostasis is important for immune cell viability during candida challenge and host survival of systemic fungal infection. Cell Metab 27(988–1006):e1007

DOI

12
Vachharajani VT, Liu T, Wang X, Hoth JJ, Yoza BK, McCall CE (2016) Sirtuins link inflammation and metabolism. J Immunol Res 2016:8167273

DOI

13
Wang F, Wang K, Xu W, Zhao S, Ye D, Wang Y, Xu Y, Zhou L, Chu Y, Zhang C (2017) SIRT5 desuccinylates and activates pyruvate kinaseM2to block macrophage IL-1beta production and to prevent DSS-induced colitis in mice. Cell Rep 19:2331–2344

DOI

14
Wen H, Gris D, Lei Y, Jha S, Zhang L, Huang MT, Brickey WJ, Ting JP (2011) Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol 12:408–415

DOI

15
Zhong L, D’Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T (2010) The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell 140:280–293

DOI

Options
Outlines

/

〈 〉