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DUB-independent regulation of pVHL by OTUD6B suppresses hepatocellular carcinoma

  • Xiaoming Dai ,
  • Jing Liu ,
  • Wenyi Wei
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  • Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA

Published date: 15 Aug 2020

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2020 The Author(s) 2020

Cite this article

Xiaoming Dai , Jing Liu , Wenyi Wei . DUB-independent regulation of pVHL by OTUD6B suppresses hepatocellular carcinoma[J]. Protein & Cell, 2020 , 11(8) : 546 -548 . DOI: 10.1007/s13238-020-00721-x

1
Bray F, Ferlay J,Soerjomataram I, Siegel RL, Torre LA, Jemal A (2018) Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 68:394–424

DOI

2
Bruick RK, McKnight SL (2001) A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294:1337–1340

DOI

3
Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O’Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A (2001) C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107:43–54

DOI

4
Gossage L, Eisen T, Maher ER (2015) VHL, the story of a tumour suppressor gene. Nat Rev Cancer 15:55–64

DOI

5
Ivan M, Haberberger T, Gervasi DC, Michelson KS, Gunzler V, Kondo K, Yang H, Sorokina I, Conaway RC, Conaway JW (2002) Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor. Proc Natl Acad Sci U S A 99:13459–13464

DOI

6
Jung CR, Hwang KS, Yoo J, Cho WK, Kim JM, Kim WH, Im DS (2006) E2-EPF UCP targets pVHL for degradation and associates with tumor growth and metastasis. Nat Med 12:809–816

DOI

7
Kaelin WG Jr, Ratcliffe PJ (2008) Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 30:393–402

DOI

8
Kim JJ, Lee SB, Jang J, Yi SY, Kim SH, Han SA, Lee JM, Tong SY, Vincelette ND, Gao B (2015) WSB1 promotes tumor metastasis by inducing pVHL degradation. Genes Dev 29:2244–2257

DOI

9
Li Z,Na X, Wang D, Schoen SR, Messing EM, Wu G (2002) Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein. J Biol Chem 277:4656–4662

DOI

10
Liu X, Zhang X, Peng Z, Li C, Wang Z, Wang C, Deng Z, Wu B, Cui Y, Wang Z (2020) Deubiquitylase OTUD6B governs pVHL stability in an enzyme independent manner and suppresses hepatocellular carcinoma metastasis. Adv Sci. https://doi.org/10. 1002/advs.201902040

DOI

11
Mevissen TE, Hospenthal MK, Geurink PP, Elliott PR, Akutsu M, Arnaudo N, Ekkebus R, Kulathu Y, Wauer T, El Oualid F (2013) OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Cell 154:169–184

DOI

12
Wang GL, Jiang BH, Rue EA, Semenza GL (1995) Hypoxiainducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci U S A 92:5510–5514

DOI

13
Wilson WR, Hay MP (2011) Targeting hypoxia in cancer therapy. Nat Rev Cancer 11:393–410

DOI

14
Zhang Q, Yan Q, Yang H, Wei W (2019) Oxygen sensing and adaptability won the 2019 Nobel Prize in Physiology or medicine. Genes Dis 6:328–332

DOI

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