LETTER

EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation

  • Jing Tang , 1,2,4,11 ,
  • Bowei Zhou 4 ,
  • Melanie J. Scott 2 ,
  • Linsong Chen 2,5 ,
  • Dengming Lai2 2,6 ,
  • Erica K. Fan 7 ,
  • Yuehua Li 2 ,
  • Qiang Wu 8 ,
  • Timothy R. Billiar 2,10 ,
  • Mark A. Wilson 2,3 ,
  • Ping Wang 9 ,
  • Jie Fan , 2,3,10
Expand
  • 1. The Department of Anesthesiology, Affiliated hospital of Guangdong Medical University, Zhanjiang 524000, China
  • 2. Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
  • 3. Research and Development, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA
  • 4. Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
  • 5. Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China
  • 6. Department of Cardiovascular Surgery, The Children’s Hospital of Zhejiang University School of Medicine, Hangzhou 310052, China
  • 7. University of Pittsburgh The Graduate School of Public Health, Pittsburgh, PA 15213, USA
  • 8. Laboratory of Tropical Biomedicine and Biotechnology, School of Tropical Medicine and Laboratory Medicine, Hainan Medical University, Haikou 571199, China
  • 9. The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA
  • 10. McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
  • 11. Key Laboratory of Organ Injury/Protection and Translational Medicine of Zhanjiang, Zhanjiang 524000, China

Published date: 15 Feb 2020

Copyright

2019 The Author(s) 2019

Cite this article

Jing Tang , Bowei Zhou , Melanie J. Scott , Linsong Chen , Dengming Lai2 , Erica K. Fan , Yuehua Li , Qiang Wu , Timothy R. Billiar , Mark A. Wilson , Ping Wang , Jie Fan . EGFR signaling augments TLR4 cell surface expression and function in macrophages via regulation of Rab5a activation[J]. Protein & Cell, 2020 , 11(2) : 144 -149 . DOI: 10.1007/s13238-019-00668-8

1
Chen YJ, Hsieh MY, Chang MY, Chen HC, Jan MS, Maa MC, Leu TH (2012) Eps8 protein facilitates phagocytosis by increasing TLR4-MyD88 protein interaction in lipopolysaccharide-stimulated macrophages. J Biol Chem 287:18806–18819

DOI

2
Husebye H, Halaas O, Stenmark H, Tunheim G, Sandanger O, Bogen B, Brech A, Latz E, Espevik T (2006) Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity. Embo J 25:683–692

DOI

3
Kawai T, Akira S (2007) TLR signaling. Semin Immunol 19:24–32

DOI

4
Kayagaki N, Wong MT, Stowe IB, Ramani SR, Gonzalez LC, Akashi-Takamura S, Miyake K, Zhang J, Lee WP, Muszynski A (2013) Noncanonical inflammasome activation by intracellular LPS independent of TLR4. Science 341:1246–1249

DOI

5
Klein DCG, Skjesol A, Kers-Rebel ED, Sherstova T, Sporsheim B, Egeberg KW, Stokke BT, Espevik T, Husebye H (2015) CD14, TLR4 and TRAM show different trafficking dynamics during LPS stimulation. Traffic 16:677–690

DOI

6
Langemeyer L, Frohlich F, Ungermann C (2018) Rab GTPase function in endosome and lysosome biogenesis. Trends in Cell Biology 28:957–970

DOI

7
Lee JJ, Kim DG, Kim DH, Simborio HL, Min W, Lee HJ, Her M, Jung SC, Watarai M, Kim S (2013) Interplay between clathrin and Rab5 controls the early phagocytic trafficking and intracellular survival of Brucella abortus within HeLa cells. J Biol Chem 288:28049–28057

DOI

8
Li Z, Scott MJ, Fan EK, Li Y, Liu J, Xiao G, Li S, Billiar TR, Wilson MA, Jiang Y (2016) Tissue damage negatively regulates LPS-induced macrophage necroptosis. Cell Death Differ 23:1428–1447

DOI

9
Mendelsohn J, Baselga J (2006) Epidermal growth factor receptor targeting in cancer. Semin Oncol 33:369–385

DOI

10
Miao EA, Rajan JV, Aderem A (2011) Caspase-1-induced pyroptotic cell death. Immunol Rev 243:206–214

DOI

11
Pilla DM, Hagar JA, Haldar AK, Mason AK, Degrandi D, Pfeffer K, Ernst RK, Yamamoto M, Miao EA, Coers J (2014) Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS. Proc Natl Acad Sci USA 111:6046–6051

DOI

12
Saltoh SI (2009) Chaperones and transport proteins regulate TLR4 trafficking and activation. Immunobiology 214:594–600

DOI

Outlines

/