Protein & Cell >

2018 , Vol. 9 >Issue 9: 814 - 819

DOI: https://doi.org/10.1007/s13238-018-0568-x

LETTER

Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants

  • Lei Yang 1 ,
  • Xiaohui Zhang 1 ,
  • Liren Wang 1 ,
  • Shuming Yin 1 ,
  • Biyun Zhu 1 ,
  • Ling Xie 1 ,
  • Qiuhui Duan 1 ,
  • Huiqiong Hu 1,2 ,
  • Rui Zheng 3 ,
  • Yu Wei 1 ,
  • Liangyue Peng 1,4 ,
  • Honghui Han 5 ,
  • Jiqin Zhang 1 ,
  • Wenjuan Qiu 3 ,
  • Hongquan Geng 3 ,
  • Stefan Siwko 6 ,
  • Xueli Zhang 1,2 ,
  • Mingyao Liu 1,6 ,
  • Dali Li , 1
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  • 1. East China Normal University and Shanghai Fengxian District Central Hospital Joint Center for Translational Medicine, Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, China
  • 2. Fengxian Hospital Affiliated to Southern Medical University, Shanghai 201499, China
  • 3. Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • 4. School of Life Sciences, Hunan Normal University, Changsha 410081, China
  • 5. Bioray Laboratories Inc., Shanghai 200241, China
  • 6. Department of Molecular and Cellular Medicine, The Institute of Biosciences and Technology, Texas AM University Health Science Center, Houston, TX 77030, USA

Published date: 21 Sep 2018

Copyright

2018 The Author(s)
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Cite this article

Lei Yang , Xiaohui Zhang , Liren Wang , Shuming Yin , Biyun Zhu , Ling Xie , Qiuhui Duan , Huiqiong Hu , Rui Zheng , Yu Wei , Liangyue Peng , Honghui Han , Jiqin Zhang , Wenjuan Qiu , Hongquan Geng , Stefan Siwko , Xueli Zhang , Mingyao Liu , Dali Li . Increasing targeting scope of adenosine base editors in mouse and rat embryos through fusion of TadA deaminase with Cas9 variants[J]. Protein & Cell, 2018 , 9(9) : 814 -819 . DOI: 10.1007/s13238-018-0568-x

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