Protein & Cell >

2018 , Vol. 9 >Issue 8: 743 - 747

DOI: https://doi.org/10.1007/s13238-017-0484-5

LETTER

CD146 is essential for PDGFRβ-induced pericyte recruitment

  • Jianan Chen 1,2 ,
  • Yongting Luo 3 ,
  • Hongxin Huang 4 ,
  • Shuilong Wu 4 ,
  • Jing Feng 1 ,
  • Jingjing Zhang , 4,5 ,
  • Xiyun Yan , 1,2
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  • 1. Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
  • 2. College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
  • 3. Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing 100193, China
  • 4. Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China
  • 5. Laboratory of Developmental Biology and Regenerative Medicine, School of Medicine, South China University of Technology, Guangzhou 510006, China

Published date: 14 Aug 2018

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2017 The Author(s) 2017. This article is an open access publication
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Cite this article

Jianan Chen , Yongting Luo , Hongxin Huang , Shuilong Wu , Jing Feng , Jingjing Zhang , Xiyun Yan . CD146 is essential for PDGFRβ-induced pericyte recruitment[J]. Protein & Cell, 2018 , 9(8) : 743 -747 . DOI: 10.1007/s13238-017-0484-5

References

Publishing order | Descend order by publishing year | Descend order by cited within
1
Andrae J, Gallini R, Betsholtz C (2008) Role of platelet-derived growth factors in physiology and medicine. Genes Dev 22:1276–1312

DOI

2
Anfosso F, Bardin N, Vivier E, Sabatier F, Sampol J, Dignat-George F (2001) Outside-in signaling pathway linked to CD146 engagement in human endothelial cells. J Biol Chem 276:1564–1569

DOI

3
Ball SG, Bayley C, Shuttleworth CA, Kielty CM (2010) Neuropilin-1 regulates platelet-derived growth factor receptor signalling in mesenchymal stem cells. Biochem J 427:29–40

DOI

4
Bell RD, Winkler EA, Sagare AP, Singh I, LaRue B, Deane R, Zlokovic BV (2010) Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron 68:409–427

DOI

5
Chen J,Luo Y, Hui H, Cai T, Huang H, Yang F,Feng J, Zhang J, Yan X (2017) CD146 coordinates brain endothelial cell-pericyte communication for blood-brain barrier development. Proc Natl Acad Sci USA 114:E7622–E7631

DOI

6
Crisan M, Yap S, Casteilla L, Chen CW, Corselli M, Park TS, Andriolo G, Sun B, Zheng B, Zhang L (2008) A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 3:301–313

DOI

7
Daneman R, Zhou L, Kebede AA, Barres BA (2010) Pericytes are required for blood-brain barrier integrity during embryogenesis. Nature 468:562–566

DOI

8
Jiang T, Zhuang J, Duan H, Luo Y, Zeng Q, Fan K, Yan H, Lu D, Ye Z, Hao J (2012) CD146 is a coreceptor for VEGFR-2 in tumor angiogenesis. Blood 120:2330–2339

DOI

9
Luo Y, Zheng C, Zhang J, Lu D, Zhuang J, Xing S, Feng J,Yang D, Yan X (2012) Recognition of CD146 as an ERM-binding protein offers novel mechanisms for melanoma cell migration. Oncogene 31:306–321

DOI

10
Porsch H, Mehic M, Olofsson B, Heldin P, Heldin CH (2014) Plateletderived growth factor beta-receptor, transforming growth factor beta type I receptor, and CD44 protein modulate each other’s signaling and stability. J Biol Chem 289:19747–19757

DOI

11
Sweeney MD, Ayyadurai S, Zlokovic BV (2016) Pericytes of the neurovascular unit: key functions and signaling pathways. Nat Neurosci 19:771–783

DOI

12
Tu T, Zhang C, Yan H, Luo Y, Kong R, Wen P, Ye Z, Chen J, Feng J,Liu F (2015) CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development. Cell Res 25:275–287

DOI

13
Zemskov EA, Loukinova E, Mikhailenko I, Coleman RA, Strickland DK, Belkin AM (2009) Regulation of platelet-derived growth factor receptor function by integrin-associated cell surface transglutaminase. J Biol Chem 284:16693–16703

DOI

14
Zhao Z, Nelson AR, Betsholtz C, Zlokovic BV (2015) Establishment and dysfunction of the blood-brain barrier. Cell 163:1064–1078

DOI

15
Zheng C, Qiu Y, Zeng Q, Zhang Y, Lu D, Yang D, Feng J, Yan X (2009) Endothelial CD146 is required for in vitro tumor-induced angiogenesis: the role of a disulfide bond in signaling and dimerization. Int J Biochem Cell Biol 41:2163–2172

DOI

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