IL-2 and IL-15 dependent thymic development of Foxp3-expressing regulatory T lymphocytes
Received date: 06 Feb 2017
Accepted date: 04 May 2017
Published date: 27 Apr 2018
Copyright
Immunosuppressive regulatory T lymphocytes (Treg) expressing the transcription factor Foxp3 play a vital role in the maintenance of tolerance of the immunesystem to self and innocuous non-self. Most Treg that are critical for the maintenance of tolerance to self, develop as an independent T-cell lineage from common T cell precursors in the thymus. In this organ, their differentiation requires signals from the T cell receptor for antigen, from co-stimulatory molecules, as well as from cytokine-receptors. Here we focus on the cytokines implicated in thymic development of Treg, with a particular emphasis on the roles of interleukin-2 (IL-2) and IL-15. The more recently appreciated involvement of TGF-β in thymic Treg development is also briefly discussed. Finally, we discuss how cytokine-dependence of Treg development allows for temporal, quantitative, and potentially qualitative modulation of this process.
Key words: regulatory T cells; thymus; differentiation; IL-2; IL-15
Cécile Apert , Paola Romagnoli , Joost P. M. van Meerwijk . IL-2 and IL-15 dependent thymic development of Foxp3-expressing regulatory T lymphocytes[J]. Protein & Cell, 2018 , 9(4) : 322 -332 . DOI: 10.1007/s13238-017-0425-3
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