REVIEW

mTORC1 signaling in hepatic lipid metabolism

  • Jinbo Han ,
  • Yiguo Wang
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  • MOE Key Laboratory of Bioinformatics, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China

Received date: 02 Mar 2017

Accepted date: 04 Apr 2017

Published date: 22 Mar 2018

Copyright

2017 The Author(s) 2017. This article is an open access publication

Abstract

The mechanistic target of rapamycin (mTOR) signaling pathway regulates many metabolic and physiological processes in different organs or tissues. Dysregulation of mTOR signaling has been implicated in many human diseases including obesity, diabetes, cancer, fatty liver diseases, and neuronal disorders. Here we review recent progress in understanding how mTORC1 (mTOR complex 1) signaling regulates lipid metabolism in the liver.

Key words: mTOR; mTORC1; lipogenesis; lipophagy

Cite this article

Jinbo Han , Yiguo Wang . mTORC1 signaling in hepatic lipid metabolism[J]. Protein & Cell, 2018 , 9(2) : 145 -151 . DOI: 10.1007/s13238-017-0409-3

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