Protein & Cell >

2018 , Vol. 9 >Issue 1: 130 - 134

DOI: https://doi.org/10.1007/s13238-017-0438-y

LETTER

A novel therapeutic anti-HBV antibody with increased binding to human FcRn improves in vivo PK in mice and monkeys

  • Ciming Kang 1 ,
  • Lin Xia 1,2 ,
  • Yuanzhi Chen 1 ,
  • Tianying Zhang 1 ,
  • Yiwen Wang 1 ,
  • Bing Zhou 1 ,
  • Min You 1 ,
  • Quan Yuan 1 ,
  • Chi-Meng Tzeng 2 ,
  • Zhiqiang An 1,3 ,
  • Wenxin Luo , 1 ,
  • Ningshao Xia 1
Expand
  • 1. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, School of Life Science, Xiamen University, Xiamen 361105, China
  • 2. Key Laboratory for Cancer T-Cell Theranostics and Clinical Translation (CTCTCT), Translational Medicine Research Center, School of Pharmaceutical Science, Xiamen University, Xiamen 361105, China
  • 3. Texas Therapeutics Institute, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA

Published date: 01 Mar 2018

Copyright

2017 The Author(s) 2017. This article is an open access publication
Fold

Cite this article

Ciming Kang , Lin Xia , Yuanzhi Chen , Tianying Zhang , Yiwen Wang , Bing Zhou , Min You , Quan Yuan , Chi-Meng Tzeng , Zhiqiang An , Wenxin Luo , Ningshao Xia . A novel therapeutic anti-HBV antibody with increased binding to human FcRn improves in vivo PK in mice and monkeys[J]. Protein & Cell, 2018 , 9(1) : 130 -134 . DOI: 10.1007/s13238-017-0438-y

References

Publishing order | Descend order by publishing year | Descend order by cited within
1
Barouch DH, Whitney JB, Moldt B, Klein F, Oliveira TY, Liu J, Stephenson KE, Chang H, Shekhar K, Gupta S (2013) Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature 503:224

2
Dall’Acqua WF, Woods RM, Ward ES, Palaszynski SR, Patel NK, Brewah YA, Wu H, Kiener PA, Langermann S (2002) Increasing the affinity of a human IgG1 for the neonatal Fc receptor: biological consequences. J Immunol 169:5171–5180

3
Dall’Acqua WF, Kiener PA, Wu H (2006) Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn). J Biol Chem 281:23514–23524

4
Datta-Mannan A, Witcher DR, Tang Y, Watkins J, Jiang W, Wroblewski VJ (2007) Humanized IgG1 variants with differential binding properties to the neonatal Fc receptor: relationship to pharmacokinetics in mice and primates. Drug Metab Dispos 35:86–94

5
Freed DC, Tang Q, Tang A, Li F, He X, Huang Z, Meng W, Xia L, Finnefrock AC, Durr E (2013) Pentameric complex of viral glycoprotein H is the primary target for potent neutralization by a human cytomegalovirus vaccine. Proc Natl Acad Sci USA 110: E4997–5005

6
Grevys A, Bern M, Foss S, Bratlie DB, Moen A, Gunnarsen KS, Aase A, Michaelsen TE, Sandlie I, Andersen JT (2015) Fc engineering of human IgG1 for altered binding to the neonatal Fc receptor affects Fc effector functions. J Immunol 194:5497–5508

7
Hinton PR, Xiong JM, Johlfs MG, Tang MT, Keller S, Tsurushita N (2005) An engineered human IgG1 antibody with longer serum half-life. J Immunol 176:346–356

8
Igawa T, Haraya K, Hattori K (2016) Sweeping antibody as a novel therapeutic antibody modality capable of eliminating soluble antigens from circulation. Immunol Rev 270:132–151

9
Marasco WA, Sui J (2007) The growth and potential of human antiviral monoclonal antibody therapeutics. Nat Biotechnol 25 (12):1421–1434

10
Petkova SB, Akilesh S, Sproule TJ, Christianson GJ, Al Khabbaz H, Brown AC, Presta LG, Meng YG, Roopenian DC (2006) Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease. Int Immunol 18:1759–1769

11
Reichert JM (2008) Monoclonal antibodies as innovative therapeutics. Curr Pharm Biotechnol 9:423

12
Robbie GJ, Criste R, Dall’acqua WF, Jensen K, Patel NK, Losonsky GA, Griffin MP (2013) A novel investigational Fc-modified humanized monoclonal antibody, motavizumab-YTE, has an extended half-life in healthy adults. Antimicrob Agents Chemother 57:6147–6153

13
Yeung YA, Wu X, Reyes AE 2nd, Vernes JM, Lien S, Lowe J, Maia M, Forrest WF, Meng YG, Damico LA (2010) A therapeutic anti-VEGF antibody with increased potency independent of pharmacokinetic half-life. Cancer Res 70:3269–3277

14
Zalevsky J, Chamberlain AK, Horton HM, Karki S, Leung IW, Sproule TJ, Lazar GA, Roopenian DC, Desjarlais JR (2010) Enhanced antibody half-life improves in vivo activity. Nat Biotechnol 28:157–159

15
Zhang TY, Yuan Q, Zhao JH, Zhang YL, Yuan LZ, Lan Y, Lo YC, Sun CP, Wu CR, Zhang JF (2016) Prolonged suppression of HBV in mice by a novel antibody that targets a unique epitope on hepatitis B surface antigen. Gut 65:658–671

Options
Outlines

/

〈 〉