LETTER

Efficient growth suppression in pancreatic cancer PDX model by fully human anti-mesothelin CAR-T cells

  • Hua Jiang 1 ,
  • Bo Song 2 ,
  • Peng Wang 2 ,
  • Bizhi Shi 1 ,
  • Qixiang Li 3 ,
  • Mingliang Fan 1 ,
  • Shengmeng Di 1 ,
  • Jie Yang 4 ,
  • Zonghai Li , 1,2
Expand
  • 1. State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, China
  • 2. CARsgen Therapeutics, Shanghai 200231, China
  • 3. Crown Biosciences, Inc. Science Technology Innovation Park, Taicang City 215400, China
  • 4. Blood Engineering Laboratory, Shanghai Blood Center, Shanghai 200051, China

Published date: 27 Dec 2017

Copyright

2017 The Author(s) 2017. This article is an open access publication

Cite this article

Hua Jiang , Bo Song , Peng Wang , Bizhi Shi , Qixiang Li , Mingliang Fan , Shengmeng Di , Jie Yang , Zonghai Li . Efficient growth suppression in pancreatic cancer PDX model by fully human anti-mesothelin CAR-T cells[J]. Protein & Cell, 2017 , 8(12) : 926 -931 . DOI: 10.1007/s13238-017-0472-9

1
Brown CE, Alizadeh D, Starr R, Weng L, Wagner JR, Naranjo A, Ostberg JR, Blanchard MS, Kilpatrick J, Simpson J (2016) N Engl J Med 375:2561–2569

DOI

2
Burris HA III, Moore MJ, Andersen J, Green MR, Rothenberg ML, Modiano MR, Cripps MC, Portenoy RK, Storniolo AM, Tarassoff P (1997) J Clin Oncol Off J Am Soc Clin Oncol 15:2403–2413

DOI

3
Carpenito C, Milone MC, Hassan R, Simonet JC, Lakhal M, Suhoski MM, Varela-Rohena A, Haines KM, Heitjan DF, Albelda SM, Carroll RG, Riley JL, Pastan I, June CH (2009) Proc Natl Acad Sci USA 106:3360–3365

DOI

4
Chang K, Pastan I (1996) Proc Natl Acad Sci USA 93:136–140

DOI

5
Chapuis AG, Thompson JA, Margolin KA, Rodmyre R, Lai IP, Dowdy K, Farrar EA, Bhatia S, Sabath DE, Cao J (2012) Proc Natl Acad Sci USA 109:4592–4597

DOI

6
Chowdhury PS, Pastan I (1999) Nat Biotechnol 17:568–572

DOI

7
Erkan M, Michalski CW, Rieder S, Reiser-Erkan C, Abiatari I, Kolb A, Giese NA, Esposito I, Friess H, Kleeff J (2008) Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc 6:1155–1161

8
Feig C, Gopinathan A, Neesse A, Chan DS, Cook N, Tuveson DA (2012) Clin Cancer Res Off J Am Assoc Cancer Res 18:4266–4276

9
Hassan R, Bullock S, Premkumar A, Kreitman RJ, Kindler H, Willingham MC, Pastan I (2007) Clin Cancer Res 13:5144–5149

DOI

10
Jin K, Teng L, Shen Y, He K, Xu Z, Li G (2010) Clin Transl Oncol Off Publ Fed Span Oncol Soc Natl Cancer Inst Mex 12:473–480

11
Kershaw MH, Westwood JA, Darcy PK (2013) Nat Rev Cancer 13:525–541

DOI

12
Lanitis E, Poussin M, Hagemann IS, Coukos G, Sandaltzopoulos R, Scholler N, Powell DJ Jr (2012) Mol Ther J Am Soc Gene Ther 20:633–643

13
Maus MV, Haas AR, Beatty GL, Albelda SM, Levine BL, Liu X, Zhao Y, Kalos M, June CH (2013) Cancer Immunol Res 1:26–31

DOI

14
Siegel R, Naishadham D, Jemal A (2012) CA Cancer J Clin 62:10–29

DOI

15
Simard EP, Ward EM, Siegel R, Jemal A (2012) CA Cancer J Clin 62:118–128

DOI

16
Waghray M, Yalamanchili M, di Magliano MP, Simeone DM (2013) Curr Opin Gastroenterol 29:537–543

DOI

Outlines

/