REVIEW

Current status and perspectives of chimeric antigen receptor modified T cells for cancer treatment

  • Zhenguang Wang ,
  • Yelei Guo ,
  • Weidong Han
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  • Molecular & Immunological Department, Bio-therapeutic Department, Chinese PLA General Hospital, Beijing 100853, China

Received date: 28 Dec 2016

Accepted date: 15 Mar 2017

Published date: 27 Dec 2017

Copyright

2017 The Author(s) 2017. This article is an open access publication

Abstract

Chimeric antigen receptor (CAR) is a recombinant immunoreceptor combining an antibody-derived targeting fragment with signaling domains capable of activating cells, which endows T cells with the ability to recognize tumor-associated surface antigens independent of the expression of major histocompatibility complex (MHC) molecules. Recent early-phase clinical trials of CAR-modified T (CAR-T) cells for relapsed or refractory B cell malignancies have demonstrated promising results (that is, anti-CD19 CAR-T in B cell acute lymphoblastic leukemia (B-ALL)). Given this success, broadening the clinical experience of CAR-T cell therapy beyond hematological malignancies has been actively investigated. Here we discuss the basic design of CAR and review the clinical results from the studies of CAR-T cells in B cell leukemia and lymphoma, and several solid tumors. We additionally discuss the major challenges in the further development and strategies for increasing anti-tumor activity and safety, as well as for successful commercial translation.

Cite this article

Zhenguang Wang , Yelei Guo , Weidong Han . Current status and perspectives of chimeric antigen receptor modified T cells for cancer treatment[J]. Protein & Cell, 2017 , 8(12) : 896 -925 . DOI: 10.1007/s13238-017-0400-z

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