REVIEW

Cellular microparticles and pathophysiology of traumatic brain injury

  • Zilong Zhao 1,2 ,
  • Yuan Zhou 1,2 ,
  • Ye Tian 1 ,
  • Min Li 3 ,
  • Jing-fei Dong , 2,4 ,
  • Jianning Zhang , 1
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  • 1. Department of Neurosurgery, Tianjin Institute of Neurology, Tianjin Medical University General Hospital, Tianjin 300052, China
  • 2. BloodWorks Northwest Research Institute, Seattle, WA 98102, USA
  • 3. Institute of Pathology, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China
  • 4. Division of Hematology, Department of Medicine, School of Medicine, University of Washington, Seattle, WA 98195, USA

Received date: 17 Feb 2017

Accepted date: 13 Apr 2017

Published date: 30 Nov 2017

Copyright

2017 The Author(s) 2017. This article is an open access publication

Abstract

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. The finding that cellular microparticles (MPs) generated by injured cells profoundly impact on pathological courses of TBI has paved the way for new diagnostic and therapeutic strategies. MPs are subcellular fragments or organelles that serve as carriers of lipids, adhesive receptors, cytokines, nucleic acids, and tissue-degrading enzymes that are unique to the parental cells. Their sub-micron sizes allow MPs to travel to areas that parental cells are unable to reach to exercise diverse biological functions. In this review, we summarize recent developments in identifying a casual role of MPs in the pathologies of TBI and suggest that MPs serve as a new class of therapeutic targets for the prevention and treatment of TBI and associated systemic complications.

Cite this article

Zilong Zhao , Yuan Zhou , Ye Tian , Min Li , Jing-fei Dong , Jianning Zhang . Cellular microparticles and pathophysiology of traumatic brain injury[J]. Protein & Cell, 2017 , 8(11) : 801 -810 . DOI: 10.1007/s13238-017-0414-6

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