REVIEW

Human gut microbiota: the links with dementia development

  • Rashad Alkasir 1 ,
  • Jing Li 1 ,
  • Xudong Li 2 ,
  • Miao Jin 2 ,
  • Baoli Zhu , 1,3
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  • 1. Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
  • 2. China-Japan Friendship Hospital, Beijing 100029, China
  • 3. Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases, The First Attainted Hospital College of Medicine, Zhejiang University, Hangzhou 310058, China

Received date: 21 Jul 2016

Accepted date: 28 Sep 2016

Published date: 17 Mar 2017

Copyright

2017 The Author(s) 2016. This article is published with open access at Springerlink.com and journal.hep.com.cn

Abstract

Dementia is a comprehensive category of brain diseases that is great enough to affect a person’s daily functioning. The most common type of dementia is Alzheimer’s disease, which makes most of cases. New researches indicate that gastrointestinal tract microbiota are directly linked to dementia pathogenesis through triggering metabolic diseases and low-grade inflammation progress. A novel strategy is proposed for the management of these disorders and as an adjuvant for psychiatric treatment of dementia and other related diseases through modulation of the microbiota (e.g. with the use of probiotics).

Cite this article

Rashad Alkasir , Jing Li , Xudong Li , Miao Jin , Baoli Zhu . Human gut microbiota: the links with dementia development[J]. Protein & Cell, 2017 , 8(2) : 90 -102 . DOI: 10.1007/s13238-016-0338-6

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