Protein & Cell >

2016 , Vol. 7 >Issue 8: 611 - 614

DOI: https://doi.org/10.1007/s13238-016-0287-0

LETTER

Ribavirin is effective against drug-resistant H7N9 influenza virus infections

  • Yuhai Bi , 1,2,3 ,
  • Gary Wong 1 ,
  • Yingxia Liu 2 ,
  • Lei Liu 2 ,
  • George F. Gao 1,2,3,4,5 ,
  • Yi Shi , 1,2,3,4
Expand
  • 1. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
  • 2. Shenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious Disease, Shenzhen Third People’s Hospital, Shenzhen 518112, China
  • 3. Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, China
  • 4. Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China
  • 5. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Disease, Zhejiang University, Hangzhou 310003, China

Published date: 12 Sep 2016

Copyright

2016 The Author(s) 2016. This article is published with open access at Springerlink.com and journal.hep.com.cn
Fold

Cite this article

Yuhai Bi , Gary Wong , Yingxia Liu , Lei Liu , George F. Gao , Yi Shi . Ribavirin is effective against drug-resistant H7N9 influenza virus infections[J]. Protein & Cell, 2016 , 7(8) : 611 -614 . DOI: 10.1007/s13238-016-0287-0

References

Publishing order | Descend order by publishing year | Descend order by cited within
1
Bi Y, Xie Q, Zhang S, Li Y, Xiao H, Jin T, Zheng W, Li J, Jia X, Sun L (2015) Assessment of the internal genes of influenza A (H7N9) virus contributing to high pathogenicity in mice. J Virol 89:2–13

DOI

2
Crotty S, Maag D, Arnold JJ, Zhong WD, Lau JYN, Hong Z, Andino R, Cameron CE (2000) The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nat Med 6:1375–1379

DOI

3
Gao GF (2014) Influenza and the live poultry trade. Science 344:235

DOI

4
Gao R, Cao B, Hu Y, Feng Z, Wang D, Hu W, Chen J, Jie Z, Qiu H, Xu K (2013) Human infection with a novel avian-origin influenza A (H7N9) virus. N Engl J Med 368:1888–1897

DOI

5
Gilbert BE, McLeay MT (2008) MegaRibavirin aerosol for the treatment of influenza A virus infections in mice. Antiviral Res 78:223–229

DOI

6
Graci JD, Cameron CE (2006) Mechanisms of action of ribavirin against distinct viruses. Rev Med Virol 16:37–48

DOI

7
Hu YW, Lu SH, Song ZG, Wang W, Hao P, Li JH, Zhang XN, Yen HL, Shi BS, Li T (2013) Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance. Lancet 381:2273–2279

DOI

8
Ilyushina NA, Hay A, Yilmaz N, Boon AC, Webster RG, Govorkova EA (2008) Oseltamivir-ribavirin combination therapy for highly pathogenic H5N1 influenza virus infection in mice. Antimicrob Agents Chemother 52:3889–3897

DOI

9
Lam TTY, Zhou BP, Wang J, Chai YJ, Shen YY, Chen XC, Ma C, Hong WS, Chen Y, Zhang YJ (2015) Dissemination, divergence and establishment of H7N9 influenza viruses in China. Nature 522:102–U265

10
Li Q, Zhou L, Zhou M, Chen Z, Li F, Wu H, Xiang N, Chen E, Tang F, Wang D (2014) Epidemiology of human infections with avian influenza A(H7N9) virus in China. N Engl J Med 370:520–532

DOI

11
Nguyen JT, Hoopes JD, Smee DF, Prichard MN, Driebe EM, Engelthaler DM, Le MH, Keim PS, Spence RP, Went GT (2009) Triple combination of oseltamivir, amantadine, and ribavirin displays synergistic activity against multiple influenza virus strains in vitro. Antimicrob Agents Chemother 53:4115–4126

DOI

12
Smee DF, Bailey KW, Wong MH, Sidwell RW (2005) Activities of oseltamivir and ribavirin used alone or in combination against infections caused by mouse-adapted recent isolates of influenza A and B viruses. Antiviral Res 65:A61–A61

13
Su S, Bi Y, Wong G, Gray GC, Gao GF, Li S (2015) Epidemiology, evolution, and recent outbreaks of avian influenza virus in china. J Virol 89:8671–8676

DOI

14
Wu Y, Bi Y, Vavricka CJ, Sun X, Zhang Y, Gao F, Zhao M, Xiao H, Qin C, He J (2013) Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses. Cell Res 23:1347–1355

DOI

15
Yen HL, Zhou J, Choy KT, Sia SF, Teng O, Ng IH, Fang VJ, Hu Y, Wang W, Cowling BJ (2014) The R292K mutation that confers resistance to neuraminidase inhibitors leads to competitive fitness loss of A/Shanghai/1/2013 (H7N9) influenza virus in ferrets. J Infect Dis 210:1900–1908

DOI

Options
Outlines

/

〈 〉