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Interferon-related secretome from direct interaction between immune cells and tumor cells is required for upregulation of PD-L1 in tumor cells

  • Yuan-Qin Yang 1 ,
  • Wen-Jie Dong 1 ,
  • Xiao-Fei Yin 2 ,
  • Yan-Ni Xu 4 ,
  • Yu Yang 5 ,
  • Jiao-Jiao Wang 1 ,
  • Su-Jing Yuan 2 ,
  • Jing Xiao 2 ,
  • Jonathan Howard DeLong 6 ,
  • Liang Chu 2 ,
  • Hai-Neng Xu 7 ,
  • Xiu-Mei Zhou 1 ,
  • Ru-Wei Wang 8 ,
  • Ling Fang 8 ,
  • Xin-Yuan Liu , 1,2 ,
  • Kang-Jian Zhang , 2,3
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  • 1. Xinyuan Institute of Medicine and Biotechnology, Zhejiang Sci-Tech University, Hangzhou 310018, China
  • 2. State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
  • 3. Sichuan Huiyang Life Science and Technology Corp., Chengdu 610021, China
  • 4. College of Life Sciences, Northwest Agriculture and Forestry University, Yangling 712100, China
  • 5. Central China Normal University, Wuhan 430079, China
  • 6. Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
  • 7. Department of Radiation Oncology, University of Pennsylvania Perelman School of Medicine, 3400 Civic Center Blvd., Philadelphia, PA 19104, USA
  • 8. Zhejiang Conba Pharmaceutical Co., Ltd, Hangzhou 310018, China

Published date: 18 Jul 2016

Copyright

2016 The Author(s) 2016. This article is published with open access at Springerlink.com and journal.hep.com.cn

Cite this article

Yuan-Qin Yang , Wen-Jie Dong , Xiao-Fei Yin , Yan-Ni Xu , Yu Yang , Jiao-Jiao Wang , Su-Jing Yuan , Jing Xiao , Jonathan Howard DeLong , Liang Chu , Hai-Neng Xu , Xiu-Mei Zhou , Ru-Wei Wang , Ling Fang , Xin-Yuan Liu , Kang-Jian Zhang . Interferon-related secretome from direct interaction between immune cells and tumor cells is required for upregulation of PD-L1 in tumor cells[J]. Protein & Cell, 2016 , 7(7) : 538 -543 . DOI: 10.1007/s13238-016-0281-6

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