The role of galectin-4 in physiology and diseases
Received date: 20 Jan 2016
Accepted date: 03 Mar 2016
Published date: 27 May 2016
Copyright
Galectin-4, a tandem repeat member of the β-galactoside- binding proteins, possesses two carbohydraterecognition domains (CRD) in a single peptide chain. This lectin is mostly expressed in epithelial cells of the intestinal tract and secreted to the extracellular. The two domains have 40% similarity in amino acid sequence, but distinctly binding to various ligands. Just because the two domains bind to different ligands simultaneously, galectin-4 can be a crosslinker and crucial regulator in a large number of biological processes. Recent evidence shows that galectin-4 plays an important role in lipid raft stabilization, protein apical trafficking, cell adhesion, wound healing, intestinal inflammation, tumor progression, etc. This article reviews the physiological and pathological features of galectin-4 and its important role in such processes.
Key words: galectin-4; lipid raft; crosslinker; intestinal inflammation; tumor progression
Zhan-Qi Cao , Xiu-Li Guo . The role of galectin-4 in physiology and diseases[J]. Protein & Cell, 2016 , 7(5) : 314 -324 . DOI: 10.1007/s13238-016-0262-9
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