REVIEW

Thermodynamics of ABC transporters

  • Xuejun C. Zhang ,
  • Lei Han ,
  • Yan Zhao
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  • National Laboratory of Macromolecules, National Center of Protein Science-Beijing, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China

Received date: 30 Jun 2015

Accepted date: 11 Aug 2015

Published date: 26 Jan 2016

Copyright

2014 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

ABC transporters form the largest of all transporter families, and their structural study has made tremendous progress over recent years. However, despite such advances, the precise mechanisms that determine the energy-coupling between ATP hydrolysis and the conformational changes following substrate binding remain to be elucidated. Here, we present our thermodynamic analysis for both ABC importers and exporters, and introduce the two new concepts of differential-binding energy and elastic conformational energy into the discussion.We hope that the structural analysis of ABC transporters will henceforth take thermodynamic aspects of transport mechanisms into account as well.

Cite this article

Xuejun C. Zhang , Lei Han , Yan Zhao . Thermodynamics of ABC transporters[J]. Protein & Cell, 2016 , 7(1) : 17 -27 . DOI: 10.1007/s13238-015-0211-z

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