Protein & Cell >

2010 , Vol. 1 >Issue 5: 417 - 418

DOI: https://doi.org/10.1007/s13238-010-0063-5

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Repurposing an old anti-fungal drug as a Hedgehog inhibitor

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  • 1. Molecular Oncology Program, DeWitt Daughtry Family Department of Surgery, University of Miami, Miami, FL 33136, USA; 2. Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755, USA; 3. Institute of Hepatopancreatobiliary Surgery of PLA, Southwest Hospital, Third Military Medical University, Chongqing 400038, China

Published date: 01 May 2010

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Camilla Giambelli, Dennis Liang Fei, Huaizhi Wang, David J. Robbins . Repurposing an old anti-fungal drug as a Hedgehog inhibitor[J]. Protein & Cell, 2010 , 1(5) : 417 -418 . DOI: 10.1007/s13238-010-0063-5

References

[1] DiMasi, J.A., Hansen, R.W., Grabowski, H.G. (2003). The price of innovation: new estimates of drug development costs. J Health Econ 22, 151-185 .10.1016/S0167-6296(02)00126-1
[2] Ghofrani, H.A., Osterloh. I.H., Grimminger, F. (2006). Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nat Rev Drug Discov 5, 689-702 .10.1038/nrd2030
[3] Kim, J., Tang, J.Y., Gong, R., Kim, J., Lee, J.J., Clemons, K.V., Chong, C.R., Chang, K.S., Fereshteh, M., Gardner, D., . (2010). Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell 17, 388-399 .10.1016/j.ccr.2010.02.027
[4] Teglund, S., Toftgard R. (2010). Hedgehog beyond medulloblastoma and basal cell carcinoma. Biochim Biophys Acta 1805, 181-208 .
[5] Yauch, R.L., Dijkgraaf, G.J., Alicke, B., Januario, T., Ahn, C.P., Holcomb, T., Pujara, K., Stinson, J., Callahan, C.A., Tang, T., . (2009). Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma. Science 326, 572-4 .10.1126/science.1179386
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