REVIEW

Iron homeostasis and tumorigenesis: molecular mechanisms and therapeutic opportunities

  • Caiguo Zhang , 1 ,
  • Fan Zhang 2
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  • 1. Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO 80045, USA
  • 2. Orthopedics Department, Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China

Received date: 16 Oct 2014

Accepted date: 04 Nov 2014

Published date: 05 Feb 2015

Copyright

2014 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Excess iron is tightly associated with tumorigenesis in multiple human cancer types through a variety of mechanisms including catalyzing the formation of mutagenic hydroxyl radicals, regulating DNA replication, repair and cell cycle progression, affecting signal transduction in cancer cells, and acting as an essential nutrient for proliferating tumor cells. Thus, multiple therapeutic strategies based on iron deprivation have been developed in cancer therapy. During the past few years, our understanding of genetic association and molecular mechanisms between iron and tumorigenesis has expanded enormously. In this review, we briefly summarize iron homeostasis in mammals, and discuss recent progresses in understanding the aberrant iron metabolism in numerous cancer types, with a focus on studies revealing altered signal transduction in cancer cells.

Cite this article

Caiguo Zhang , Fan Zhang . Iron homeostasis and tumorigenesis: molecular mechanisms and therapeutic opportunities[J]. Protein & Cell, 2015 , 6(2) : 88 -100 . DOI: 10.1007/s13238-014-0119-z

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