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The hierarchy quorum sensing network in Pseudomonas aeruginosa

  • Jasmine Lee 1 ,
  • Lianhui Zhang , 1,2
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  • 1. Institute of Molecular and Cell Biology, Agency for Science, Technology and Research, Singapore, Singapore
  • 2. Guangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Natural Resources and Environmental Sciences, South China Agricultural University, Guangzhou 510642, China

Received date: 29 Jul 2014

Accepted date: 28 Aug 2014

Published date: 22 Jan 2015

Copyright

2014 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Pseudomonas aeruginosa causes severe and persistent infections in immune compromised individuals and cystic fibrosis sufferers. The infection is hard to eradicate as P. aeruginosa has developed strong resistance to most conventional antibiotics. The problem is further compounded by the ability of the pathogen to form biofilm matrix, which provides bacterial cells a protected environment withstanding various stresses including antibiotics. Quorum sensing (QS), a cell density-based intercellular communication system, which plays a key role in regulation of the bacterial virulence and biofilm formation, could be a promising target for developing new strategies against P. aeruginosa infection. The QS network of P. aeruginosa is organized in a multi-layered hierarchy consisting of at least four interconnected signaling mechanisms. Evidence is accumulating that the QS regulatory network not only responds to bacterial population changes but also could react to environmental stress cues. This plasticity should be taken into consideration during exploration and development of anti-QS therapeutics.

Cite this article

Jasmine Lee , Lianhui Zhang . The hierarchy quorum sensing network in Pseudomonas aeruginosa[J]. Protein & Cell, 2015 , 6(1) : 26 -41 . DOI: 10.1007/s13238-014-0100-x

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