Protein & Cell >

2015 , Vol. 6 >Issue 1: 6 - 11

DOI: https://doi.org/10.1007/s13238-014-0122-4

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Mutation analysis of large tumor suppressor genes LATS1 and LATS2 supports a tumor suppressor role in human cancer

  • Tian Yu 1 ,
  • John Bachman 2 ,
  • Zhi-Chun Lai , 1,2,3
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  • 1. Intercollege Graduate Degree Program in Molecular, Cellular and Integrative Biosciences, The Pennsylvania State University, University Park, PA 16802, USA
  • 2. Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA
  • 3. Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA

Received date: 09 Oct 2014

Accepted date: 13 Nov 2014

Published date: 22 Jan 2015

Copyright

2014 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

In recent years, human cancer genome projects provide unprecedented opportunities for the discovery of cancer genes and signaling pathways that contribute to tumor development. While numerous gene mutations can be identified from each cancer genome, what these mutations mean for cancer is a challenging question to address, especially for those from less understood putative new cancer genes. As a powerful approach, in silico bioinformatics analysis could efficiently sort out mutations that are predicted to damage gene function. Such an analysis of human large tumor suppressor genes, LATS1 and LATS2, has been carried out and the results support a role of hLATS1//2 as negative growth regulators and tumor suppressors.

Key words： LATS1 & LATS2; hippo signaling; cancer genome; human cancer

Cite this article

Tian Yu , John Bachman , Zhi-Chun Lai . Mutation analysis of large tumor suppressor genes LATS1 and LATS2 supports a tumor suppressor role in human cancer[J]. Protein & Cell, 2015 , 6(1) : 6 -11 . DOI: 10.1007/s13238-014-0122-4

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