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A partial pathway- and network-based transformation reveals the synergistic mechanism of JA and UA against cerebral ischemia-reperfusion injury

  • Shanshan Guo 1 ,
  • Li Guo 2 ,
  • Yanan Yu 3 ,
  • Bing Li 4 ,
  • Yingying Zhang 2 ,
  • Haixia Li 2 ,
  • Ping Wu 2 ,
  • Jie Wang 2 ,
  • Ye Yuan 3 ,
  • Zhong Wang , 3 ,
  • Yongyan Wang 3
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  • 1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
  • 2. Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100700, China
  • 3. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
  • 4. Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China

Published date: 20 Nov 2014

Copyright

2014 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Cite this article

Shanshan Guo , Li Guo , Yanan Yu , Bing Li , Yingying Zhang , Haixia Li , Ping Wu , Jie Wang , Ye Yuan , Zhong Wang , Yongyan Wang . A partial pathway- and network-based transformation reveals the synergistic mechanism of JA and UA against cerebral ischemia-reperfusion injury[J]. Protein & Cell, 2014 , 5(11) : 873 -877 . DOI: 10.1007/s13238-014-0098-0

1
Brasier AR, Recinos A III, Eledrisi MS (2002) Vascular inflammation and the renin-angiotensin system. Arterioscler Thromb Vasc Biol22: 1257-1266

DOI

2
Cheng F, Wang X, Lu Y, Zhong X, Zhao Y, Wang Q (2012) Chinese medicine injection qingkailing for treatment of acute is<?Pub Caret?>chemia stroke: a systematic review of randomized controlled trials. Evid Based Complement Altern Med2012: 213172

DOI

3
Cho DY, Kim YA, Przytycka TM (2012) Chapter 5: network biology approach to complex diseases. PLoS Comput Biol8: e1002820

DOI

4
DeGracia DJ, Kumar R, Owen CR, Krause GS, White BC (2002) Molecular pathways of protein synthesis inhibition during brain reperfusion: implications for neuronal survival or death. J Cereb Blood Flow Metab22: 127-141

DOI

5
Ekdahl CT, Kokaia Z, Lindvall O (2009) Brain inflammation and adult neurogenesis: the dual role of microglia. Neuroscience158: 1021-1029

DOI

6
Fouda AY, Kozak A, Alhusban A, Switzer JA, Fagan SC (2013) Antiinflammatory IL-10 is upregulated in both hemispheres after experimental ischemic stroke: hypertension blunts the response. Exp Transl Stroke Med5: 12

DOI

7
Jafarinaveh HR, Allahtavakoli M, Rezazadeh H, Kazemi Arababadi M, Taghavi MM, Shamsizadeh A, Rahmani MR (2014) Proinflammatory cytokines in the embolic model of cerebral ischemia in rat. Iran J Allergy Asthma Immunol13: 125-130

8
Li S, Zhang B, Zhang N (2011) Network target for screening synergistic drug combinations with application to traditional Chinese medicine. BMC Syst Biol 5(Suppl 1): S10-682

DOI

9
Liu J, Zhou CX, Zhang ZJ, Wang LY, Jing ZW, Wang Z (2012) Synergistic mechanism of gene expression and pathways between jasminoidin and ursodeoxycholic acid in treating focal cerebral ischemia-reperfusion injury. CNS Neurosci Ther18: 674-682

DOI

10
Simao F, Matte A, Breier AC, Kreutz F, Trindade VM, Netto CA, Salbego CG (2013) Resveratrol prevents global cerebral ischemia- induced decrease in lipid content. Neurol Res35: 59-64

DOI

11
Suzuki S, Tanaka K, Suzuki N (2009) Ambivalent aspects of interleukin-6 in cerebral ischemia: inflammatory versus neurotrophic aspects. J Cereb Blood Flow Metab29: 464-479

DOI

12
Takeda Y, Perez-Pinzon MA, Ginsberg MD, Sick TJ (2004) Mitochondria consume energy and compromise cellular membrane potential by reversing ATP synthetase activity during focal ischemia in rats. J Cereb Blood Flow Metab24: 986-992

DOI

13
Wek RC, Jiang HY, Anthony TG (2006) Coping with stress: eIF2 kinases and translational control. Biochem Soc Trans34: 7-11

DOI

14
Zhan X, Ander BP, Jickling G, Turner R, Stamova B, Xu H, Liu D, Davis RR, Sharp FR (2010) Brief focal cerebral ischemia that simulates transient ischemic attacks in humans regulates gene expression in rat peripheral blood. J Cereb Blood Flow Metab30: 110-118

DOI

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