REVIEW

Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control

  • Caiguo Zhang
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  • Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO 80045, USA

Received date: 01 Apr 2014

Accepted date: 04 May 2014

Published date: 24 Oct 2014

Copyright

2014 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Eukaryotic cells contain numerous iron-requiring proteins such as iron-sulfur (Fe-S) cluster proteins, hemoproteins and ribonucleotide reductases (RNRs). These proteins utilize iron as a cofactor and perform key roles in DNA replication, DNA repair, metabolic catalysis, iron regulation and cell cycle progression. Disruption of iron homeostasis always impairs the functions of these ironrequiring proteins and is genetically associated with diseases characterized by DNA repair defects in mammals. Organisms have evolved multi-layered mechanisms to regulate iron balance to ensure genome stability and cell development. This review briefly provides current perspectives on iron homeostasis in yeast and mammals, and mainly summarizes the most recent understandings on iron-requiring protein functions involved in DNA stability maintenance and cell cycle control.

Cite this article

Caiguo Zhang . Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control[J]. Protein & Cell, 2014 , 5(10) : 750 -760 . DOI: 10.1007/s13238-014-0083-7

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