REVIEW

Telomere regulation in pluripotent stem cells

  • Yan Huang 1 ,
  • Puping Liang 1 ,
  • Dan Liu 2,3,4 ,
  • Junjiu Huang , 1 ,
  • Zhou Songyang , 1,4
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  • 1. Key Laboratory of Reproductive Medicine of Guangdong Province, the First Affiliated Hospital and Key Laboratory of Gene Engineering of the Ministry of Education, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China
  • 2. Cell-Based Assay Screening Core, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
  • 3. Dan L. Duncan Cancer Center, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
  • 4. Verna and Marrs Mclean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA

Received date: 12 Jan 2014

Accepted date: 23 Jan 2014

Published date: 23 Jun 2014

Copyright

2014 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Pluripotent stem cells (PSCs) have the potential to produce any types of cells from all three basic germ layers and the capacity to self-renew and proliferate indefinitely in vitro. The two main types of PSCs, embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), share common features such as colony morphology, high expression of Oct4 and Nanog, and strong alkaline phosphatase activity. In recent years, increasing evidences suggest that telomere length represents another important internal factor in maintaining stem cell pluripotency. Telomere length homeostasis and its structural integrity help to protect chromosome ends from recombination, end fusion, and DNA damage responses, ensuring the divisional ability of mammalian cells. PSCs generally exhibit high telomerase activity to maintain their extremely long and stable telomeres, and emerging data indicate the alternative lengthening of telomeres (ALT) pathway may play an important role in telomere functions too. Such characteristics are likely key to their abilities to differentiate into diverse cell types in vivo. In this review,we will focus on the function and regulation of telomeres in ESCs and iPSCs, thereby shedding light on the importance of telomere length to pluripotency and the mechanisms that regulate telomeres in PSCs.

Cite this article

Yan Huang , Puping Liang , Dan Liu , Junjiu Huang , Zhou Songyang . Telomere regulation in pluripotent stem cells[J]. Protein & Cell, 2014 , 5(3) : 194 -202 . DOI: 10.1007/s13238-014-0028-1

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