Protein & Cell >

2010 , Vol. 1 >Issue 6: 520 - 536

DOI: https://doi.org/10.1007/s13238-010-0065-3

Research articles

The next-generation sequencing technology and application

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  • 1.Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China；The Joint Laboratory of Bioinformation Acquisition and Sensing Technology, Beijing 100029, China; 2.Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100029, China; 3.Institute of Semiconductor, Chinese Academy of Sciences, Beijing 100083, China；The Joint Laboratory of Bioinformation Acquisition and Sensing Technology, Beijing 100029, China;

Published date: 01 Jun 2010

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Abstract

As one of the key technologies in biomedical research, DNA sequencing has not only improved its productivity with an exponential growth rate but also been applied to new areas of application over the past few years. This is largely due to the advent of newer generations of sequencing platforms, offering ever-faster and cheaper ways to analyze sequences. In our previous review, we looked into technical characteristics of the next-generation sequencers and provided prospective insights into their future development. In this article, we present a brief overview of the advantages and shortcomings of key commercially available platforms with a focus on their suitability for a broad range of applications.

Key words： next-generation sequencing technology; RNA-seq; ChIP-seq; metagenome; transcriptome; epigenome

Cite this article

Xiaoguang Zhou, Lufeng Ren, Jun Yu, Qingshu Meng, Yuntao Li, Yude Yu, . The next-generation sequencing technology and application[J]. Protein & Cell, 2010 , 1(6) : 520 -536 . DOI: 10.1007/s13238-010-0065-3

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