Protein & Cell >

2010 , Vol. 1 >Issue 3: 227 - 236

DOI: https://doi.org/10.1007/s13238-010-0032-z

Research articles

DNA replication licensing control and rereplication prevention

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  • 1.Department of Biochemistry and Molecular Biology, The University of Texas Medical School at Houston, Houston, TX 77030, USA; 2.Department of Biochemistry and Molecular Biology, The University of Texas Medical School at Houston, Houston, TX 77030, USA；The Graduate School of Biomedical Sciences, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA;

Published date: 01 Mar 2010

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Abstract

Eukaryotic DNA replication is tightly restricted to only once per cell cycle in order to maintain genome stability. Cells use multiple mechanisms to control the assembly of the prereplication complex (pre-RC), a process known as replication licensing. This review focuses on the regulation of replication licensing by posttranslational modifications of the licensing factors, including phosphorylation, ubiquitylation and acetylation. These modifications are critical in establishing the pre-RC complexes as well as preventing rereplication in each cell cycle. The relationship between rereplication and diseases, including cancer and virus infection, is discussed as well.

Key words： DNA replication licensing; rereplication; protein modification

Cite this article

Chonghua Li, Jianping Jin, . DNA replication licensing control and rereplication prevention[J]. Protein & Cell, 2010 , 1(3) : 227 -236 . DOI: 10.1007/s13238-010-0032-z

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