Molecular architecture of mammalian pyruvate dehydrogenase complex

Maofei Chen; Yutong Song; Sensen Zhang; Yitang Zhang; Xudong Chen; Minghui Zhang; Meng Han; Xin Gao; Sai Li; Maojun Yang

doi:10.1093/procel/pwae044

Protein Cell ›› 2025, Vol. 16 ›› Issue (1) : 72 -78. DOI: 10.1093/procel/pwae044

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Molecular architecture of mammalian pyruvate dehydrogenase complex

Maofei Chen ¹^,²
, Yutong Song ¹^,³
, Sensen Zhang ¹^,²
, Yitang Zhang ¹^,²
, Xudong Chen ¹^,²
, Minghui Zhang ⁴
, Meng Han ⁵
, Xin Gao ⁶^,⁷
, Sai Li ¹^,³^,^†
, Maojun Yang ¹^,²^,⁸^,⁹^,^†

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¹. Tsinghua-Peking Center for Life Sciences, Beijing Frontier Research Center for Biological Structure, School of Life Sciences, Tsinghua University, Beijing 100084, China

². Ministry of Education Key Laboratory of Protein Science, Tsinghua University, Beijing 100084, China

³. State Key Laboratory of Membrane Biology, Tsinghua University, Beijing 100084, China

⁴. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Shenzhen University Health Science Center, Shenzhen 518060, China

⁵. Protein Research Technology Center, Protein Chemistry and Omics Platform, School of Life Sciences, Tsinghua University, Beijing 100084, China

⁶. Computer Science Program, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia

⁷. Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of Saudi Arabia

⁸. Cryo-EM Facility Center, Southern University of Science and Technology, Shenzhen 518055, China

⁹. Beijing Life Science Academy, Beijing 102209, China

sai@tsinghua.edu.cn

maojunyang@tsinghua.edu.cn

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Maofei Chen, Yutong Song, Sensen Zhang, Yitang Zhang, Xudong Chen, Minghui Zhang, Meng Han, Xin Gao, Sai Li, Maojun Yang. Molecular architecture of mammalian pyruvate dehydrogenase complex. Protein Cell, 2025, 16(1): 72-78 DOI:10.1093/procel/pwae044

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