ARID1A IDR targets EWS-FLI1 condensates and finetunes chromatin remodeling

Jingdong Xue , Siang Lv , Ming Yu , Yixuan Pan , Ningzhe Li , Xiang Xu , Qi Zhang , Mengyuan Peng , Fang Liu , Xuxu Sun , Yimin Lao , Yanhua Yao , Juan Song , Jun Wu , Bing Li

Protein Cell ›› 2025, Vol. 16 ›› Issue (1) : 64 -71.

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Protein Cell ›› 2025, Vol. 16 ›› Issue (1) : 64 -71. DOI: 10.1093/procel/pwae029
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ARID1A IDR targets EWS-FLI1 condensates and finetunes chromatin remodeling

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Jingdong Xue, Siang Lv, Ming Yu, Yixuan Pan, Ningzhe Li, Xiang Xu, Qi Zhang, Mengyuan Peng, Fang Liu, Xuxu Sun, Yimin Lao, Yanhua Yao, Juan Song, Jun Wu, Bing Li. ARID1A IDR targets EWS-FLI1 condensates and finetunes chromatin remodeling. Protein Cell, 2025, 16(1): 64-71 DOI:10.1093/procel/pwae029

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References

[1]

Boija A, Klein IA, Sabari BR et al. Transcription factors activate genes through the phase-separation capacity of their activation domains. Cell 2018;175:1842–1855.e16.

[2]

Boulay G, Sandoval GJ, Riggi N et al. Cancer-specific retargeting of BAF complexes by a prion-like domain. Cell 2017;171:163–178.e19.

[3]

Clapier CR, Iwasa J, Cairns BR et al. Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes. Nat Rev Mol Cell Biol 2017;18:407–422.

[4]

Han Y, Reyes AA, Malik S et al. Cryo-EM structure of SWI/SNF complex bound to a nucleosome. Nature 2020;579:452–455.

[5]

Hassan AH, Neely KE, Workman JL. Histone acetyltransferase complexes stabilize SWI/SNF binding to promoter nucleosomes. Cell 2001;104:817–827.

[6]

He S, Wu Z, Tian Y et al. Structure of nucleosome-bound human BAF complex. Science 2020;367:875–881.

[7]

Huh JW, Wu J, Lee CH et al. Multivalent di-nucleosome recognition enables the Rpd3S histone deacetylase complex to tolerate decreased H3K36 methylation levels. EMBO J 2012;31:3564–3574.

[8]

Hyman AA, Weber CA, Jülicher F. Liquid-liquid phase separation in biology. Annu Rev Cell Dev Biol 2014;30:39–58.

[9]

Kadoch C, Hargreaves DC, Hodges C et al. Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. Nat Genet 2013;45:592–601.

[10]

Mashtalir N, D’Avino AR, Michel BC et al. Modular organization and assembly of SWI/SNF family chromatin remodeling complexes. Cell 2018;175:1272–1288.e20.

[11]

Nodelman IM, Bowman GD. Biophysics of chromatin remodeling. Annu Rev Biophys 2021;50:73–93.

[12]

Patil A, Strom AR, Paulo JA et al. A disordered region controls cBAF activity via condensation and partner recruitment. Cell 2023;186:4936–4955.e26.

[13]

Wolf BK, Zhao Y, McCray A et al. Cooperation of chromatin remodeling SWI/SNF complex and pioneer factor AP-1 shapes 3D enhancer landscapes. Nat Struct Mol Biol 2022;30:10–21.

[14]

Wu JN, Roberts CWM. ARID1A mutations in cancer: another epigenetic tumor suppressor? Cancer Discov 2013;3:35–43.

[15]

Zhang L, Chen Y, Li MJ et al. HRP2–DPF3a–BAF complex coordinates histone modification and chromatin remodeling to regulate myogenic gene transcription. Nucleic Acids Res 2020;48:6563–6582.

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The Author(s) 2024. Published by Oxford University Press on behalf of Higher Education Press.

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