How erastin assassinates cells by ferroptosis revealed

Boyi Gan

PDF(760 KB)
PDF(760 KB)
Protein Cell ›› 2023, Vol. 14 ›› Issue (2) : 84-86. DOI: 10.1093/procel/pwac007
COMMENTARY
COMMENTARY

How erastin assassinates cells by ferroptosis revealed

Author information +
History +

Cite this article

Download citation ▾
Boyi Gan. How erastin assassinates cells by ferroptosis revealed. Protein Cell, 2023, 14(2): 84‒86 https://doi.org/10.1093/procel/pwac007

References

[1]
Dixon SJ, Lemberg KM, Lamprecht MR et al. Ferroptosis: an irondependent form of nonapoptotic cell death. Cell 2012;149:1060–1072.
CrossRef Google scholar
[2]
Dolma S, Lessnick SL, Hahn WC et al. Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 2003;3:285–296.
CrossRef Google scholar
[3]
Feng H, Stockwell BR. Unsolved mysteries: how does lipid peroxidation cause ferroptosis? PLoS Biol. 2018;16:e2006203.
CrossRef Google scholar
[4]
Jiang X, Stockwell BR, Conrad M. Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol. 2021;22: 266–282.
CrossRef Google scholar
[5]
Koppula P, Zhang Y, Zhuang L et al. Amino acid transporter SLC7A11/xCT at the crossroads of regulating redox homeostasis and nutrient dependency of cancer. Cancer Commun (Lond) 2018;38:12.
CrossRef Google scholar
[6]
Koppula P, Zhuang L, Gan B. Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy. Protein Cell. 2021;12:599–620.
CrossRef Google scholar
[7]
Lei G, Zhuang L, Gan B. Targeting ferroptosis as a vulnerability in cancer. Nat Rev Cancer. 2022;22:381–396.
CrossRef Google scholar
[8]
Tang D, Chen X, Kang R et al. Ferroptosis: molecular mechanisms and health implications. Cell Res. 2021;31:107–125.
CrossRef Google scholar
[9]
Yan R, Xie E, Li Y et al. The structure of erastin-bound xCT-4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis. Cell Res. 2022;32:687–690.
CrossRef Google scholar
[10]
Yang WS, SriRamaratnam R, Welsch ME et al. Regulation of ferroptotic cancer cell death by GPX4. Cell 2014;156:317–331.
CrossRef Google scholar

RIGHTS & PERMISSIONS

2022 The Author(s) 2022. Published by Oxford University Press on behalf of Higher Education Press.
AI Summary AI Mindmap
PDF(760 KB)

Accesses

Citations

Detail

Sections
Recommended

/