Single-cell RNA sequencing reveals B cell-T cell interactions in vascular adventitia of hyperhomocysteinemia-accelerated atherosclerosis

Xiaolong Ma, Jiacheng Deng, Lulu Han, Yuwei Song, Yutong Miao, Xing Du, Guohui Dang, Dongmin Yang, Bitao Zhong, Changtao Jiang, Wei Kong, Qingbo Xu, Juan Feng, Xian Wang

PDF(2197 KB)
PDF(2197 KB)
Protein Cell ›› 2022, Vol. 13 ›› Issue (7) : 540-547. DOI: 10.1007/s13238-021-00904-0
LETTER

Single-cell RNA sequencing reveals B cell-T cell interactions in vascular adventitia of hyperhomocysteinemia-accelerated atherosclerosis

Author information +
History +

Cite this article

Download citation ▾
Xiaolong Ma, Jiacheng Deng, Lulu Han, Yuwei Song, Yutong Miao, Xing Du, Guohui Dang, Dongmin Yang, Bitao Zhong, Changtao Jiang, Wei Kong, Qingbo Xu, Juan Feng, Xian Wang. Single-cell RNA sequencing reveals B cell-T cell interactions in vascular adventitia of hyperhomocysteinemia-accelerated atherosclerosis. Protein Cell, 2022, 13(7): 540‒547 https://doi.org/10.1007/s13238-021-00904-0

References

[1]
AltarejosJY, Montminy M (2011) CREB and the CRTC co-activators: sensors for hormonal and metabolic signals. Nat Rev Mol Cell Biol 12:141–151
CrossRef Google scholar
[2]
DaiJ, LiW, ChangL, Zhang Z, TangC, WangN, ZhuY, WangX (2006) Role of redox factor-1 in hyperhomocysteinemia-accelerated atherosclerosis. Free Radic Biol Med 41:1566–1577
CrossRef Google scholar
[3]
DengT, LyonCJ, MinzeLJ, Lin J, ZouJ, LiuJZ, RenY, YinZ, Hamilton DJ, ReardonPR et al (2013) Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation. Cell Metab 17:411–422
CrossRef Google scholar
[4]
DengJ, LuS, LiuH, LiuB, JiangC, Xu Q, FengJ, WangX (2017) Homocysteine activates B cells via regulating PKM2-dependent metabolic reprogramming. J Immunol 198:170–183
CrossRef Google scholar
[5]
HuoY, LiJ, QinX, HuangY, WangX, Gottesman RF, TangG, WangB, ChenD, HeM et al (2015) Efficacy of folic acid therapy in primary prevention of stroke among adults with hypertension in China: the CSPPT randomized clinical trial. JAMA 313:1325–1335
CrossRef Google scholar
[6]
JinS, Guerrero-Juarez CF, ZhangL, ChangI, RamosR, KuanCH, Myung P, PlikusMV, NieQ (2021) Inference and analysis of cellcell communication using Cell Chat. Nat Commun 12:1088
CrossRef Google scholar
[7]
KobayashiKS, van den Elsen PJ (2012) NLRC5: a key regulator of MHC class I-dependent immune responses. Nat Rev Immunol 12:813–820
CrossRef Google scholar
[8]
LuoY, FengJ, XuQ, WangW, WangX (2016) NSun2 Deficiency protects endothelium from inflammation via mRNA methylation of ICAM-1. Circ Res 118:944–956
CrossRef Google scholar
[9]
OkiS, OhtaT, ShioiG, Hatanaka H, OgasawaraO, OkudaY, Kawaji H, NakakiR, SeseJ, MenoC (2018) ChIP-Atlas: a data-mining suite powered by full integration of public ChIP-seq data. EMBO Rep 19
CrossRef Google scholar
[10]
StuartT, Butler A, HoffmanP, HafemeisterC, Papalexi E, MauckWM, 3rd, HaoY, Stoeckius M, SmibertP, SatijaR (2019) Comprehensive Integration of Single-Cell Data. Cell 177:1888–1902 e1821
CrossRef Google scholar
[11]
TruelsenT, Krarup LH, IversenHK, MensahGA, Feigin VL, SposatoLA, NaghaviM (2015) Causes of death data in the global burden of disease estimates for ischemic and hemorrhagic stroke. Neuroepidemiology 45:152–160
CrossRef Google scholar
[12]
van der StoepN, Quinten E, van den ElsenPJ (2002) Transcriptional regulation of the MHC class II trans-activator (CIITA) promoter III: identification of a novel regulatory region in the 5’-untranslated region and an important role for cAMP-responsive element binding protein 1 and activating transcription factor-1 in CIITA-promoter III transcriptional activation in B lymphocytes. J Immunol 169:5061–5071
CrossRef Google scholar
[13]
WeberG, Camagni G (1950) Frequency and entity of aortic atherosclerosis in chronic and acute endocarditis; inflammatory genesis of the atherosclerotic process. Arch De Vecchi Anat Patol 14:45–69
[14]
WinkelsH, Ehinger E, VassalloM, BuscherK, DinhHQ, KobiyamaK, Hamers AAJ, CochainC, VafadarnejadE, Saliba AE et al (2018) Atlas of the immune cell repertoire in mouse atherosclerosis defined by single-cell RNA-sequencing and mass cytometry. Circ Res 122:1675–1688
CrossRef Google scholar
[15]
WooCW, SiowYL, OK, (2006) Homocysteine activates cAMPresponse element binding protein in HepG2 through cAMP/PKA signaling pathway. Arterioscler Thromb Vasc Biol 26:1043–1050
CrossRef Google scholar

RIGHTS & PERMISSIONS

2022 The Author(s) 2022
AI Summary AI Mindmap
PDF(2197 KB)

Accesses

Citations

Detail

Sections
Recommended

/