Governing glutaminolysis by regulation of glutaminase succinylation

Qingxia Ma , Hongfei Jiang , Leina Ma , Ying Meng , Dong Guo , Yingying Tong , Zhimin Lu

Protein Cell ›› 2022, Vol. 13 ›› Issue (3) : 163 -166.

PDF (245KB)
Protein Cell ›› 2022, Vol. 13 ›› Issue (3) : 163 -166. DOI: 10.1007/s13238-021-00897-w
COMMENTARY
COMMENTARY

Governing glutaminolysis by regulation of glutaminase succinylation

Author information +
History +
PDF (245KB)

Cite this article

Download citation ▾
Qingxia Ma, Hongfei Jiang, Leina Ma, Ying Meng, Dong Guo, Yingying Tong, Zhimin Lu. Governing glutaminolysis by regulation of glutaminase succinylation. Protein Cell, 2022, 13(3): 163-166 DOI:10.1007/s13238-021-00897-w

登录浏览全文

4963

注册一个新账户 忘记密码

References

[1]

ChinopoulosC (2021) The mystery of extramitochondrial proteins lysine succinylation. Int J Mol Sci 22:6085

[2]

JiangH, ZhuL, XuD, LuZ (2020) A newly discovered role of metabolic enzyme PCK1 as a protein kinase to promote cancer lipogenesis. Cancer Commun 40:389–394

[3]

JiangH, LinQ, MaL, LuoS, JiangX, Fang J, LuZ (2021) Fructose and fructose kinase in cancer and other pathologies. J Genet Genomics 48:531–539

[4]

JingY, DingD, TianG, Kwan KCJ, LiuZ, IshibashiT, LiXD (2020) Semisynthesis of site-specifically succinylated histone reveals that succinylation regulates nucleosome unwrapping rate and DNA accessibility. Nucleic Acids Res 48:9538–9549

[5]

LiX, QianX, LuZ (2016a) Fructokinase A acts as a protein kinase to promote nucleotide synthesis. Cell Cycle 15:2689–2690

[6]

LiX, ZhengY, LuZ (2016b) PGK1 is a new member of the protein kinome. Cell Cycle 15:1803–1804

[7]

LiX, QianX, LuZ (2017) Local histone acetylation by ACSS2 promotes gene transcription for lysosomal biogenesis and autophagy. Autophagy 13:1790–1791

[8]

LiX, Egervari G, WangY, BergerSL, LuZ (2018a) Regulation of chromatin and gene expression by metabolic enzymes and metabolites. Nat Rev Mol Cell Biol 19:563–578

[9]

LiX, QianX, JiangH, Xia Y, ZhengY, LiJ, HuangBJ, FangJ, Qian CN, JiangT et al (2018b) Nuclear PGK1 alleviates ADP-dependent inhibition of CDC7 to promote DNA replication. Mol Cell 72:650–660

[10]

LiuX, ZhuC, ZhaH, TangJ, RongF, Chen X, FanS, XuC, DuJ, ZhuJ et al (2020) SIRT5 impairs aggregation and activation of the signaling adaptor MAVS through catalyzing lysine desuccinylation. EMBO J 39:e103285

[11]

LiuX, RongF, TangJ, Zhu C, ChenX, JiaS, WangZ, SunX, DengH, ZhaH et al (2021) Repression of p53 function by SIRT5-mediated desuccinylation at Lysine 120 in response to DNA damage. Cell Death Differ

[12]

LuZ (2012) PKM2 functions as a histone kinase. Cell Cycle 11:4101–4102

[13]

LuZ, HunterT (2018) Metabolic kinases moonlighting as protein kinases. Trends Biochem Sci 43:301–310

[14]

SonJ, Lyssiotis A, YingH, WangX, HuaS, LigorioM, Perera M, FerroneR, MullarkyE, Shyh-Chang N, KangYA (2013) Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature 496:101–105

[15]

TongY, GuoD, YanD, MaC, ShaoF, Wang Y, LuoS, LinL, TaoJ, JiangY et al (2020) KAT2A succinyltransferase activity-mediated 14-3-3zeta upregulation promotes beta-catenin stabilization-dependent glycolysis and proliferation of pancreatic carcinoma cells. Cancer Lett 469:1–10

[16]

TongY, GuoD, LinSH, Liang J, YangD, MaC, ShaoF, LiM, YuQ, JiangY et al (2021) SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells. Mol Cell 81:2303–2316

[17]

WangY, GuoYR, LiuK, YinZ, LiuR, XiaY, TanL, YangP, LeeJH, Li XJ et al (2017) KAT2A coupled with the alpha-KGDH complex acts as a histone H3 succinyltransferase. Nature 552:273–277

[18]

WangY, GuoYR, XingD, Tao YJ, LuZ (2018a) Supramolecular assembly of KAT2A with succinyl-CoA for histone succinylation. Cell Discov 4:47

[19]

WangY, XiaY, LuZ (2018b) Metabolic features of cancer cells. Cancer Commun 38:65

[20]

XuD, ShaoF, BianX, Meng Y, LiangT, LuZ (2021) The evolving landscape of noncanonical functions of metabolic enzymes in cancer and other pathologies. Cell Metab 33:33–50

RIGHTS & PERMISSIONS

The Author(s) 2021

AI Summary AI Mindmap
PDF (245KB)

532

Accesses

0

Citation

Detail

Sections
Recommended

AI思维导图

/