Governing glutaminolysis by regulation of glutaminase succinylation

Qingxia Ma, Hongfei Jiang, Leina Ma, Ying Meng, Dong Guo, Yingying Tong, Zhimin Lu

PDF(245 KB)
PDF(245 KB)
Protein Cell ›› 2022, Vol. 13 ›› Issue (3) : 163-166. DOI: 10.1007/s13238-021-00897-w
COMMENTARY
COMMENTARY

Governing glutaminolysis by regulation of glutaminase succinylation

Author information +
History +

Cite this article

Download citation ▾
Qingxia Ma, Hongfei Jiang, Leina Ma, Ying Meng, Dong Guo, Yingying Tong, Zhimin Lu. Governing glutaminolysis by regulation of glutaminase succinylation. Protein Cell, 2022, 13(3): 163‒166 https://doi.org/10.1007/s13238-021-00897-w

References

[1]
ChinopoulosC (2021) The mystery of extramitochondrial proteins lysine succinylation. Int J Mol Sci 22:6085
CrossRef Google scholar
[2]
JiangH, ZhuL, XuD, LuZ (2020) A newly discovered role of metabolic enzyme PCK1 as a protein kinase to promote cancer lipogenesis. Cancer Commun 40:389–394
CrossRef Google scholar
[3]
JiangH, LinQ, MaL, LuoS, JiangX, Fang J, LuZ (2021) Fructose and fructose kinase in cancer and other pathologies. J Genet Genomics 48:531–539
CrossRef Google scholar
[4]
JingY, DingD, TianG, Kwan KCJ, LiuZ, IshibashiT, LiXD (2020) Semisynthesis of site-specifically succinylated histone reveals that succinylation regulates nucleosome unwrapping rate and DNA accessibility. Nucleic Acids Res 48:9538–9549
CrossRef Google scholar
[5]
LiX, QianX, LuZ (2016a) Fructokinase A acts as a protein kinase to promote nucleotide synthesis. Cell Cycle 15:2689–2690
CrossRef Google scholar
[6]
LiX, ZhengY, LuZ (2016b) PGK1 is a new member of the protein kinome. Cell Cycle 15:1803–1804
CrossRef Google scholar
[7]
LiX, QianX, LuZ (2017) Local histone acetylation by ACSS2 promotes gene transcription for lysosomal biogenesis and autophagy. Autophagy 13:1790–1791
CrossRef Google scholar
[8]
LiX, Egervari G, WangY, BergerSL, LuZ (2018a) Regulation of chromatin and gene expression by metabolic enzymes and metabolites. Nat Rev Mol Cell Biol 19:563–578
CrossRef Google scholar
[9]
LiX, QianX, JiangH, Xia Y, ZhengY, LiJ, HuangBJ, FangJ, Qian CN, JiangT et al (2018b) Nuclear PGK1 alleviates ADP-dependent inhibition of CDC7 to promote DNA replication. Mol Cell 72:650–660
CrossRef Google scholar
[10]
LiuX, ZhuC, ZhaH, TangJ, RongF, Chen X, FanS, XuC, DuJ, ZhuJ et al (2020) SIRT5 impairs aggregation and activation of the signaling adaptor MAVS through catalyzing lysine desuccinylation. EMBO J 39:e103285
CrossRef Google scholar
[11]
LiuX, RongF, TangJ, Zhu C, ChenX, JiaS, WangZ, SunX, DengH, ZhaH et al (2021) Repression of p53 function by SIRT5-mediated desuccinylation at Lysine 120 in response to DNA damage. Cell Death Differ
CrossRef Google scholar
[12]
LuZ (2012) PKM2 functions as a histone kinase. Cell Cycle 11:4101–4102
CrossRef Google scholar
[13]
LuZ, HunterT (2018) Metabolic kinases moonlighting as protein kinases. Trends Biochem Sci 43:301–310
CrossRef Google scholar
[14]
SonJ, Lyssiotis A, YingH, WangX, HuaS, LigorioM, Perera M, FerroneR, MullarkyE, Shyh-Chang N, KangYA (2013) Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature 496:101–105
CrossRef Google scholar
[15]
TongY, GuoD, YanD, MaC, ShaoF, Wang Y, LuoS, LinL, TaoJ, JiangY et al (2020) KAT2A succinyltransferase activity-mediated 14-3-3zeta upregulation promotes beta-catenin stabilization-dependent glycolysis and proliferation of pancreatic carcinoma cells. Cancer Lett 469:1–10
CrossRef Google scholar
[16]
TongY, GuoD, LinSH, Liang J, YangD, MaC, ShaoF, LiM, YuQ, JiangY et al (2021) SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells. Mol Cell 81:2303–2316
CrossRef Google scholar
[17]
WangY, GuoYR, LiuK, YinZ, LiuR, XiaY, TanL, YangP, LeeJH, Li XJ et al (2017) KAT2A coupled with the alpha-KGDH complex acts as a histone H3 succinyltransferase. Nature 552:273–277
CrossRef Google scholar
[18]
WangY, GuoYR, XingD, Tao YJ, LuZ (2018a) Supramolecular assembly of KAT2A with succinyl-CoA for histone succinylation. Cell Discov 4:47
CrossRef Google scholar
[19]
WangY, XiaY, LuZ (2018b) Metabolic features of cancer cells. Cancer Commun 38:65
CrossRef Google scholar
[20]
XuD, ShaoF, BianX, Meng Y, LiangT, LuZ (2021) The evolving landscape of noncanonical functions of metabolic enzymes in cancer and other pathologies. Cell Metab 33:33–50
CrossRef Google scholar

RIGHTS & PERMISSIONS

2021 The Author(s) 2021
AI Summary AI Mindmap
PDF(245 KB)

Accesses

Citations

Detail

Sections
Recommended

/