Roles of Tet2 in meiosis, fertility and reproductive aging

Huasong Wang, Linlin Liu, Mo Gou, Guian Huang, Chenglei Tian, Jiao Yang, Haiying Wang, Qin Xu, Guo_Liang Xu, Lin Liu

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Protein Cell ›› 2021, Vol. 12 ›› Issue (7) : 578-585. DOI: 10.1007/s13238-020-00805-8
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Roles of Tet2 in meiosis, fertility and reproductive aging

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Huasong Wang, Linlin Liu, Mo Gou, Guian Huang, Chenglei Tian, Jiao Yang, Haiying Wang, Qin Xu, Guo_Liang Xu, Lin Liu. Roles of Tet2 in meiosis, fertility and reproductive aging. Protein Cell, 2021, 12(7): 578‒585 https://doi.org/10.1007/s13238-020-00805-8

References

[1]
Cimmino L, Dolgalev I, Wang Y, Yoshimi A, Martin GH, Wang J, Ng V, Xia B, Witkowski MT, Mitchell-Flack M (2017) Restoration of TET2 function blocks aberrant self-renewal and leukemia progression. Cell 170(1079–1095):e1020
CrossRef Google scholar
[2]
Dawlaty MM, Breiling A, Le T, Raddatz G, Barrasa MI, Cheng AW, Gao Q, Powell BE, Li Z, Xu M (2013) Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development. Dev Cell 24:310–323
CrossRef Google scholar
[3]
Delhommeau F, Dupont S, Della Valle V, James C, Trannoy S, Masse A, Kosmider O, Le Couedic JP, Robert F, Alberdi A (2009) Mutation in TET2 in myeloid cancers. N Engl J Med 360:2289–2301
CrossRef Google scholar
[4]
Ferrone CK, Blydt-Hansen M, Rauh MJ (2020) Age-associated TET2 mutations: common drivers of myeloid dysfunction. Cancer and cardiovascular disease. Int J Mol Sci 21:626
CrossRef Google scholar
[5]
Hon GC, Song CX, Du T, Jin F, Selvaraj S, Lee AY, Yen CA, Ye Z, Mao SQ, Wang BA (2014) 5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation. Mol Cell 56:286–297
CrossRef Google scholar
[6]
Horvath S, Raj K (2018) DNA methylation-based biomarkers and the epigenetic clock theory of ageing. Nat Rev Genet 19:371–384
CrossRef Google scholar
[7]
Huang G, Liu L, Wang H, Gou M, Gong P, Tian C, Deng W, Yang J, Zhou TT, Xu GL (2020) Tet1 deficiency leads to premature reproductive aging by reducing spermatogonia stem cells and germ cell differentiation. iScience 23:100908
CrossRef Google scholar
[8]
Ko M, Huang Y, Jankowska AM, Pape UJ, Tahiliani M, Bandukwala HS, An J, Lamperti ED, Koh KP, Ganetzky R (2010) Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2. Nature 468:839–843
CrossRef Google scholar
[9]
London N, Biggins S (2014) Signalling dynamics in the spindle checkpoint response. Nat Rev Mol Cell Biol 15:736–747
CrossRef Google scholar
[10]
Lu F, Liu Y, Jiang L, Yamaguchi S, Zhang Y (2014) Role of Tet proteins in enhancer activity and telomere elongation. Genes Dev 28:2103–2119
CrossRef Google scholar
[11]
Marangos P, Stevense M, Niaka K, Lagoudaki M, Nabti I, Jessberger R, Carroll J (2015) DNA damage-induced metaphase I arrest is mediated by the spindle assembly checkpoint and maternal age. Nat Commun 6:8706
CrossRef Google scholar
[12]
Moran-Crusio K, Reavie L, Shih A, Abdel-Wahab O, Ndiaye-Lobry D, Lobry C, Figueroa ME, Vasanthakumar A, Patel J, Zhao X (2011) Tet2 loss leads to increased hematopoietic stem cell selfrenewal and myeloid transformation. Cancer Cell 20:11–24
CrossRef Google scholar
[13]
Saitou M, Miyauchi H (2016) Gametogenesis from Pluripotent Stem Cells. Cell Stem Cell 18:721–735
CrossRef Google scholar
[14]
Wu X, Zhang Y (2017) TET-mediated active DNA demethylation: mechanism, function and beyond. Nat Rev Genet 18:517–534
CrossRef Google scholar
[15]
Yamaguchi S, Hong K, Liu R, Shen L, Inoue A, Diep D, Zhang K, Zhang Y (2012) Tet1 controls meiosis by regulating meiotic gene expression. Nature 492:443–447
CrossRef Google scholar

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